Retinoic acid regulated insulin-like growth factor gene expression in cord blood lymphocytes.

Abstract:

OBJECTIVE:To explore the immune promotion mechanism of retinoic acid (RA). METHODS:Reverse Transcription-Polymerase chain reaction (RT-PCR) was used to detect the gene expression of insulin like growth factor I (IGF-I) and IGF receptors (IGF-IR and IGF-IIR) in vitro, and their regulation by RA in human cord blood lymphocyte (CBL). RESULTS:Significant upregulation of IGF-I, IGF-IR and IGF-IIR mRNA was found at 6-24 hours in CBL incubated with physiologic concentrations of RA as compared to those without RA. CONCLUSION:The enhancement of IGF expression may be an important pathway for vitamin A to promote immune cellular functions.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Yang Y,Wang W,Su Y

keywords:

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

170-2

issue

2

eissn

0366-6999

issn

2542-5641

journal_volume

114

pub_type

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