Induction of apoptosis by homoharringtonine in G1 phase human chronic myeloid leukemic cells.

abstract：Background:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement is a severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out this ...

journal_title：Chinese medical journal

authors： Song Y,Pei RJ,Wang YN,Zhang J,Wang Z

更新日期：2018-04-05 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that ephrin-A2 and -A3 negatively regulate the growth of neural progenitor cells in the central nervous system. Adult mice deficient in ephrin-A2 and -A3 (A2(-/-)A3(-/-)) displayed active ongoing neurogenesis throughout the brain, and mice deficient in ephrin-A3 alone sho...

journal_title：Chinese medical journal

authors： Zhu R,Cho KS,Chen DF,Yang L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The best age for the arterial switch operation (ASO) in complete transposition of great arteries with ventricular septal defect is usually considered to be within six months. This is because of severe pulmonary arterial hypertension and pulmonary arterial obstructive pathological changes. There are few repor...

journal_title：Chinese medical journal

authors： Liu CH,Su JW,Li ZQ,Fan XM,Chen Y,He Y,Liu YL

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To review the progress of cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells. DATA SOURCES:The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for papers published from January 2000 to January 2012 with the key words of "bone marr...

journal_title：Chinese medical journal

authors： Liu BW,Lü AL,Hou J,Huang W,Li Y,Hou ZL,Hou H,Da J,Yang N,Ai SY

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The major consequence of pulmonary arteriovenous malformations (PAVMs) is the direct inflow of blood from the pulmonary artery to the pulmonary vein which induces hypoxemia. Severe complications include transient ischemic attacks, paradoxical embolization in the central nervous system, massive hemoptysis or ...

journal_title：Chinese medical journal

authors： Liu FY,Wang MQ,Fan QS,Duan F,Wang ZJ,Song P

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Roundabout 5 (R5) is a monoclonal antibody which can neutralize the binding of Roundabout 1 (Robo1) to Slit2. Oral squamous cell carcinoma angiogenesis was significantly inhibited when R5 blocked slit-robo signaling pathway. However, the effect of R5 on the invasion of tongue cancer cells has not been invest...

journal_title：Chinese medical journal

authors： Xiao R,Zhao Y,Wang LJ,Li WP

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) contributes greatly to renal tubulointerstitial fibrosis, which is the final event leading to end-stage renal failure. This study was designed to investigate the effects of CTGF antisense oligodeoxynucleotides (ODNs) on the expressions of plasminogen activator inhibitor...

journal_title：Chinese medical journal

authors： Zhang C,Meng XF,Zhu ZH,Yang X,Deng AG

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the beta(3)-adrenergic-receptor (beta(3)-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population. METHODS:Polymerase chain reaction-o...

journal_title：Chinese medical journal

authors： Wang G,Li Q,Niu T,Chen C,Xu X

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The development of the targeted signal transduction inhibitor STI571 has prompted us to treat chronic myeloid leukemia in different ways. Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo. METHODS:Multidrug-res...

journal_title：Chinese medical journal

authors： Gao L,Chen L,Fei XH,Qiu HY,Zhou H,Wang JM

更新日期：2006-06-05 00:00:00

abstract：BACKGROUND:The medial patellofemoral ligament (MPFL) reconstruction is popular in clinical practice for chronic patellar dislocation; however, the combination with vastus medialis advancement is rare. The aim of this study was to evaluate the clinical outcome of the combination of MPFL reconstruction with vastus medial...

journal_title：Chinese medical journal

authors： Wang F,Kang HJ,Chen BC,Chen W,Su YL,Zhang YZ

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Intratracheal instillation of blood induces self-repaired acute lung injury. However, the mechanism of repair has been unclear. Heme-oxygenase (HO)-1, which catalyzes heme breakdown, acts as an inducible defense against oxidative stress and plays an important role in inflammation. The objective of this study...

journal_title：Chinese medical journal

authors： Pang QF,Zhou QM,Zeng S,Dou LD,Ji Y,Zeng YM

更新日期：2008-09-05 00:00:00

abstract：Background:Recent advances in extracorporeal membrane oxygenation (ECMO) have led to increasing interest in its use during cardiopulmonary resuscitation (CPR). However, decisions regarding extracorporeal CPR (ECPR) in children are difficult as a result of limited studies, especially in Asia Pacific. The objective of th...

journal_title：Chinese medical journal

authors： Chen GL,Qiao YR,Ma JH,Wang JX,Hei FL,Yu J

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:Na + /Ca 2+ exchanger (NCX) plays a crucial role in pentylenetetrazol-induced convulsion. However, it is unclear whether NCX is critically involved in hyperthermia-induced convulsion. In this study, we examined the potential changes in NCX3 in the hippocampus and cerebrocortex of rats with hyperthermia-induc...

journal_title：Chinese medical journal

authors： Sun D,Xiao JH,Bai Y,Chen MS,Hu JS,Wu GF,Mao B,Wu SH,Hu Y

更新日期：2015-11-20 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that many neurons may die through apoptosis in Alzheimer's disease (AD). Mitochondrial dysfunction has been implicated in this process of neuronal cell death. One promising approach for preventing AD is based upon anti-apoptosis to decrease death of nerve cells. In this study, we...

journal_title：Chinese medical journal

authors： Pan R,Qiu S,Lu DX,Dong J

更新日期：2008-05-05 00:00:00

abstract：BACKGROUND:Estrogen deficiency causes atrophic changes within the urogenital tract, and is associated with urinary symptoms. The purpose of this study was to investigate the effects of estrogen and tibolone on bladder histology, and the changes of estrogen receptor alpha and beta (ERalpha and beta) protein expression i...

journal_title：Chinese medical journal

authors： Yang X,Li YZ,Mao Z,Gu P,Shang M

更新日期：2009-02-20 00:00:00

abstract：BACKGROUND:Combination paclitaxel and carboplatin is currently a first-line regimen for ovarian cancer. However, many patients develop tumor recurrence or drug resistance to this regimen. The study aims to investigate the effectiveness and safety of an oxaliplatin + epirubicin + ifosfamide regimen for the treatment of ...

journal_title：Chinese medical journal

authors： Zhang G,Li XP,Liu BJ,Wang JL,Wang SJ,Cui H,Wei LH

更新日期：2013-12-01 00:00:00

abstract：:Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

journal_title：Chinese medical journal

authors： Zhuang YY,Li JJ,Wang JJ

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:The P53 tumor suppressor gene shows the most frequent genetic alteration in human tumors. Mutation, deletion and rearrangement of P53 gene have been found in several types of neoplasm including osteosarcoma. The present study is to clarify the status of abnormalities of this gene in osteosarcoma in China. MA...

journal_title：Chinese medical journal

authors： Guo W,Wang X,Feng C

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To explore the involvement of calcium in the mechanism of hypoxic/hypoglycemic insults and nerve growth factor (NGF) protection. METHODS:Neuron viability and lactate dehydrogenase (LDH) efflux in the bathing medium in cerebral cortex cultures from fetal rats were measured. Calcium fluorescent indicator Fura-...

journal_title：Chinese medical journal

authors： Wu J,Zhang J

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Fractional flow reserve (FFR) has become an increasingly important index when making decisions with respect to revascularization of coronary artery stenosis. However, the pressure guidewire used in obtaining FFR measurements is difficult to control and manipulate in certain complex coronary artery lesions, r...

journal_title：Chinese medical journal

authors： He WM,Li CL,Sun Y,Zhou Z,Mai YF

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Nowadays, there is a remarkable rise in resectability rate of periampullary adenocarcinoma and the mortality and morbidity of the pancreaticoduodenectomy procedure have been reduced remarkably, while the 5 year survival rates of patients with carcinoma of the head of the pancreas are still below 25%. We cond...

journal_title：Chinese medical journal

authors： Yang YM,Wan YL,Tian XD,Zhuang Y,Huang YT

更新日期：2005-11-20 00:00:00

abstract：BACKGROUND:The Medtronic InSync Sentry is the first available cardiac resynchronization therapy defibrillator (CRT-D) which can monitor fluid status by measuring intrathoracic impedance. This study was designed to observe the effectiveness of intrathoracic impedance monitoring on detecting aggravation of heart failure....

journal_title：Chinese medical journal

authors： Qiao Q,Hua W,Ding LG,Chen KP,Wang J,Wang FZ,Zhang S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To explore the association of human leukocyte antigen (HLA) with pregnancy induced hypertension (PIH). METHODS:We oligotyped HLA-DQA1, -DQB1 locus of 30 Chinese PIH families and 14 control families in Shanghai area by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) hybridization method ...

journal_title：Chinese medical journal

authors： Mao Y,Zhang Z,Fan L,Wu Q,Jiang L,Yang J,Yao F

更新日期：1998-02-01 00:00:00

abstract：:The long-term prognosis and causes of death of myocardial infarction (MI) in 62 diabetics were studied. The mean follow-up time was 6.2 years, 11 patients died in the acute stage of MI, 9 of them (81.8%) had anterior infarction and their major causes of death were ventricular fibrillation and cardiogenic shock (72.2%)...

journal_title：Chinese medical journal

authors： Qian RL,Feng JG

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Ahmed Glaucoma Valve implantation (AGVI) is used to treat refractory glaucoma. Breakdown of the blood-aqueous barrier (BAB) has been noted after some surgical techniques. The current study was designed to assess BAB disruption after AGVI. METHODS:Anterior chamber protein content was measured by the laser fl...

journal_title：Chinese medical journal

authors： Zhou MW,Wang W,Chen SD,Huang WB,Zhang XL

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Using tissue Doppler imaging and conventional echocardiographic technique, we examined the cardiac function and synchronicity in individuals with isolated right bundle branch block (RBBB) or left bundle branch block (LBBB) and assessed the relationship between QRS duration and synchronicity. METHODS:Subject...

journal_title：Chinese medical journal

authors： Niu HX,Hua W,Zhang S,Sun X,Wang FZ,Chen KP,Wang H,Chen X

更新日期：2006-05-20 00:00:00

abstract：BACKGROUND:Our previous research has suggested that genes around D12S1056 in 12q13 may confer susceptibility to ventricular septal defect (VSD) in humans. The present study was to define the chromosome region assignment by transmission disequilibrium test (TDT), and to identify the important candidate gene by family-ba...

journal_title：Chinese medical journal

authors： Qiu GR,Gong LG,He G,Xu XY,Xin N,Sun GF,Yuan YH,Sun KL

更新日期：2006-02-20 00:00:00

abstract：OBJECTIVE:To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats. METHODS:Male Sprague Dawley (SD) rats were scheduled to undergo 3-hour middle cerebral artery occlusion by intraluminal suture and 24-hour reperfusio...

journal_title：Chinese medical journal

authors： Chen L,Gong Q,Xiao C

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM). METHODS:Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese wo...

journal_title：Chinese medical journal

authors： Lin J,Zhang X,Qian Y,Ye Y,Shi Y,Xu K,Xu J

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To review the characteristics and evolution of the fungal spectrum, and the risk factors causing fungal infection, and to make progress in diagnosing fungal infection after organ transplantation. DATA SOURCES:An English-language literature search (MEDLINE 1990 - 2000) and bibliographic review of textbooks and ...

journal_title：Chinese medical journal

authors： Hong W,Wen H,Liao W

更新日期：2003-09-01 00:00:00