Glutathione S-transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study.

Abstract:

OBJECTIVE:To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM). METHODS:Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese women with endometriosis and 28 without endometriosis. RESULTS:The frequencies of GSTM1 and GSTT1 null genotypes in women with endometriosis were 0.721 (49/68) and 0.779 (53/68), respectively, and in women without endometriosis were 0.429 (12/28) and 0.321 (9/28), respectively. There was a significant difference with regard to the frequencies of GSTM1 and GSTT1 null genotypes between the women with and without endometriosis (P < 0.01). Furthermore, the frequencies of GSTM1 and GSTT1 null genotypes were significantly higher in the patients with stage III and IV endometriosis [0.731 (38/52) and 0.788 (41/52), respectively] than in women without endometriosis (P < 0.01), and the frequency of GSTT1 null genotype was statistically higher in patients with stage I and II endometriosis [0.75 (12/16)] than in the women without endometriosis (P < 0.01). No correlation between GSTM1 and GSTT1 null genotypes and age, induced abortion or dysmenorrhea was detected in this study (P > 0.05). CONCLUSION:GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Lin J,Zhang X,Qian Y,Ye Y,Shi Y,Xu K,Xu J

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

777-80

issue

5

eissn

0366-6999

issn

2542-5641

journal_volume

116

pub_type

杂志文章
  • Presence of serum antinuclear antibodies correlating unfavorable overall survival in patients with chronic lymphocytic leukemia.

    abstract:BACKGROUND:Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), but the prognostic value of ANAs remains unknown. The aim of this study was to evaluate the role of ANAs as a prognostic factor in CLL. METHODS:This study retrospectively analyzed clinical data from 21...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000000114

    authors: Sun Q,Wang L,Zhu HY,Miao Y,Wu W,Liang JH,Cao L,Xia Y,Wu JZ,Wang Y,Wang R,Fan L,Xu W,Li JY

    更新日期:2019-03-05 00:00:00

  • Effect of homocysteine on plaque formation and oxidative stress in patients with acute coronary syndromes.

    abstract:BACKGROUND:Cardiovascular diseases, especially coronary artery disease (CAD), are major causes of death in industrialized countries. Elevated concentrations of plasma homocysteine (Hcy) have been associated with an increased risk of CAD. Increased plasma levels of chemokine, characterized by their ability to induce mig...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang G,Mao JM,Wang X,Zhang FC

    更新日期:2004-11-01 00:00:00

  • Intraoperative coronary venography in observing changes of portal blood flow after portal-azygos disconnection.

    abstract::Intraoperative coronary venography was performed in 24 patients before and after portal-azygos disconnection for portal hypertension. Before the procedure the portal vein was found to be communicated with cardial and esophageal veins by two pathways, i,e., from the esophageal and gastric branches of the coronary vein ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zou ZS,Li JS,Li N,Liu FK

    更新日期:1990-12-01 00:00:00

  • Effects of hepatocyte growth factor-mediated activation of Dll4-Notch-Hey2 signaling pathway.

    abstract:BACKGROUND:Hepatocyte growth factor (HGF) treats ischemic disease by promoting arteriogenesis, however, its mechanism of action is not known. The notch signaling pathway plays an important role in neovascularization. The relationship between the proliferation and migration ability of artery endothelial cells and the Dl...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Gao YF,Ha XQ,Lü TD,Han JP

    更新日期:2011-01-01 00:00:00

  • Vitamin D receptor and its protective role in diabetic nephropathy.

    abstract:OBJECTIVE:To review the advances of studies on vitamin D receptor and its role in the pathogenesis of diabetic nephropathy. DATA SOURCES:A comprehensive search of the PubMed literatures without restriction on the publication date was carried out using keywords such as vitamin D receptor and diabetic nephropathy. STUD...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Guan X,Yang H,Zhang W,Wang H,Liao L

    更新日期:2014-01-01 00:00:00

  • Endothelial progenitor cells with Alzheimer's disease.

    abstract:BACKGROUND:Endothelial dysfunction is thought to be critical events in the pathogenesis of Alzheimer's disease (AD). Endothelial progenitor cells (EPCs) have provided insight into maintaining and repairing endothelial function. To study the relation between EPCs and AD, we explored the number of circulating EPCs in pat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Kong XD,Zhang Y,Liu L,Sun N,Zhang MY,Zhang JN

    更新日期:2011-03-01 00:00:00

  • Induced pluripotent stem cells.

    abstract::Induced pluripotent stem (iPS) cells are a recent development which has brought a promise of great therapeutic values. The previous technique of somatic cell nuclear transfer (SCNT) has been ineffective in humans. Recent discoveries show that human fibroblasts can be reprogrammed by a transient over expression of a sm...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Bhowmik S,Li Y

    更新日期:2011-06-01 00:00:00

  • Safety and efficacy of first-line bevacizumab combined with taxane therapy in Chinese patients with HER2-negative locally recurrent or metastatic breast cancer: findings from the ATHENA study.

    abstract:BACKGROUND:Three randomised trials have demonstrated that combining bevacizumab with first-line chemotherapy significantly improves progression-free survival versus chemotherapy alone in HER2-negative locally recurrent/metastatic breast cancer (LR/mBC). However, data from Chinese populations are limited and possible di...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Xu BH,Jiang ZF,Shen ZZ,Guan ZZ,Chen ZD,Cheng Y,Zheng H,Jiang J,Wang XJ,Tong ZS,Qin SK,Luo Y,Yao M,Wang LW,He J

    更新日期:2012-03-01 00:00:00

  • Quantitative differentiation of dendritic cells in lung tissues of smokers with and without chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is thought to be an inflammatory immune response disease. In most cases, the disease is caused by cigarette smoke, but it has been demonstrated that only 10% to 20% of smokers will definitely suffer from COPD. Dendritic cells (DCs) are considered to be the promote...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Su YW,Xu YJ,Liu XS

    更新日期:2010-06-01 00:00:00

  • Anastomotic false aneurysm following abdominal aortic aneurysmectomy and prosthetic grafting.

    abstract::Anastomotic false aneurysm (AFA) of the aorta is a potentially lethal complication after prosthetic grafting. Nineteen aneurysms were encountered in 18 patients within a 30-year period (1960-1991). There were 10 men and 8 women, aged 27-80 years (mean 58 years). In 14 patients, the prostheses were made of silk, in 2 w...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen FZ,Xu X,Fu WG,Wu ZG

    更新日期:1994-11-01 00:00:00

  • Comparison of visual performance between conventional LASIK and wavefront-guided LASIK with iris-registration.

    abstract:BACKGROUND:Laser in situ keratomileusis (LASIK) has become an efficient and commonly performed procedure to reduce refractive errors. In order to further increase the postoperative visual quality, the wavefront-guided refractive surgery has been a research hotspot in customized surgery. This study was conducted to comp...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang J,Zhou YH,Wang NL,Li R

    更新日期:2008-01-20 00:00:00

  • Orthotopic ileal neobladder similar to original bladder.

    abstract:OBJECTIVE:To report the surgical techniques and results of an 8-year follow-up study of 42 patients with a modified orthotopic ileal neobladder restoring normal anatomical relationship. METHODS:Total cystoprostatectomy was performed extraperitoneally. A 45 - 50 cm segment of the ileal loop was isolated, detubularized,...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Huang J,Xu K,Yao Y,Guo Z,Lin T,Jiang C

    更新日期:2003-12-01 00:00:00

  • Stepwise approach to substrate modification of ventricular tachycardia after myocardial infarction.

    abstract:BACKGROUND:Recently, substrate mapping (SM) has been described to facilitate catheter ablation of stable and unstable ventricular tachycardia (VT) after myocardial infarction. However, SM is time consuming with potential disadvantages of multiple ablation lines such as impairment of ventricular function or proarrhythmi...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li YG,Grönefeld G,Israel C,Lu SB,Wang QS,Meng S,Hohnloser SH

    更新日期:2006-07-20 00:00:00

  • Temporary arterial occlusion during intracranial aneurysm surgery.

    abstract::Temporary arterial occlusion during intracranial aneurysm surgery is a safe and effective modality. It is not only an emergency measure for controlling aneurysmal bleeding, but also a helpful means for accurate and meticulous dissection and clipping of an intracranial aneurysm with the advantage of minimizing the chan...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhou LF,Li SQ,Yang ML

    更新日期:1993-11-01 00:00:00

  • Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997-2006.

    abstract:BACKGROUND:Despite the prevalence of Streptococcus pneumoniae serotype 19A, the molecular characteristics of this serotype are yet to be fully elucidated. The aim of this study was therefore to determine the homology of the serotype 19A in China. METHODS:Pulsed-field gel electrophoresis and multilocus sequence typing ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xue L,Yao KH,Yu SJ,Liu ZJ,Qian J,Shen XZ,Yang YH

    更新日期:2011-06-01 00:00:00

  • Downregulation of Notch-regulated Ankyrin Repeat Protein Exerts Antitumor Activities against Growth of Thyroid Cancer.

    abstract:BACKGROUND:The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells. The role of NRARP in carcinogenesis deserves extensive investigations. This study attempted to investigate the expression of NRARP in thyroid cancer tissues and assess the influence of NRARP ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.184465

    authors: Chu BF,Qin YY,Zhang SL,Quan ZW,Zhang MD,Bi JW

    更新日期:2016-07-05 00:00:00

  • Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma.

    abstract:BACKGROUND:Although it is recognized that bronchial smooth muscle cells (BSMCs) play a key role in airway remodeling during chronic asthma, it is not well understood how BSMCs exert their inflammatory functions. The extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway is an important signaling pathway i...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xie M,Liu XS,Xu YJ,Zhang ZX,Bai J,Ni W,Chen SX

    更新日期:2008-01-05 00:00:00

  • Preliminary study on controlled hypotension induced by nimodipine in craniocerebral surgery.

    abstract::Nimodipine, produced in China, was applied to lower the blood pressure (BP) in 20 cases in craniocerebral operation. 0.02% solution of Nimodipine was dripped intravenously (by 0.02% of density), at a preliminary speed of 600-800 micrograms/min, and 4-12 mg of total dose. Mean arterial pressure (MAP) decreased and main...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Zhang P,Wang B,Wang E,Chen X

    更新日期:1995-06-01 00:00:00

  • Effect of Platelet-derived P-selectin on Neutrophil Recruitment in a Mouse Model of Sepsis-induced Acute Kidney Injury.

    abstract:BACKGROUND:Acute kidney injury (AKI) is a severe disease in critically ill patients. Neutrophil infiltration into kidney was associated with the development of AKI, and P-selectin may be involved in the process of neutrophil recruitment in kidney. This study aimed to explore the potential effect of platelet-derived P-s...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.209889

    authors: Li XH,Qian YB,Meng XX,Wang RL

    更新日期:2017-07-20 00:00:00

  • Role of BK(Ca) channels in diabetic vascular complications.

    abstract:OBJECTIVE:This review focuses on the role of the large conductance calcium-activated potassium (BKCa) channels in diabetic vascular complications. DATA SOURCES:Relevant articles published in English or Chinese from 1981 to present were selected from PubMed. The search terms were "BKCa channels" and "diabetes". Importa...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Qian L,Liu X,Wang R

    更新日期:2014-01-01 00:00:00

  • Effects of shenmai injection on pulmonary aquaporin 1 in rats following traumatic brain injury.

    abstract:BACKGROUND:Aquaporin-1 (AQP1) has involved in fluid transport in diverse pulmonary edema diseases. Our study aimed to explore the dynamic changes of AQP1 in pulmonary water metabolism in rats following traumatic brain injury (TBI) and the protective effect provided by shenmai injection. METHODS:Sixty male Sprague Dawl...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Bai Y,Yao HX,Hu ML,Wang LR,Jin LD,Wang WT,Lin LN

    更新日期:2011-02-01 00:00:00

  • HLA-DQA1, -DQB1 polymorphism distribution in Chinese women with pregnancy induced hypertension in Shanghai area.

    abstract:OBJECTIVE:To explore the association of human leukocyte antigen (HLA) with pregnancy induced hypertension (PIH). METHODS:We oligotyped HLA-DQA1, -DQB1 locus of 30 Chinese PIH families and 14 control families in Shanghai area by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) hybridization method ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Mao Y,Zhang Z,Fan L,Wu Q,Jiang L,Yang J,Yao F

    更新日期:1998-02-01 00:00:00

  • Transitional cell carcinoma associated with aristolochic acid nephropathy: most common cancer in chronic hemodialysis patients in China.

    abstract:BACKGROUND:The research of cancer in patients on hemodialysis (HD) in China has not been reported. The aim of this study was to investigate the clinical and histological features and outcomes of cancer in Chinese HD patients. METHODS:The study subjects were 49 cancer patients (1.4%) out of 3448 end stage renal disease...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhou L,Cao YL,Li WG,Fu FT,Zhang L,Wang X,Shi XH

    更新日期:2012-12-01 00:00:00

  • Laparoendoscopic single-site radical prostatectomy: technique and initial outcomes.

    abstract:BACKGROUND:Laparoendoscopic single-site surgery radical prostatectomy (LESS-RP) is a challenging urological procedure and needs to be further evaluated. This study was undertaken to illustrate the safety and initial results of pure LESS-RP with conventional available instruments. METHODS:A prospective clinical databas...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu G,Zhang YQ,Grange P,Walsh K,Jin B,Zhang YG,Chen X,Wang X,Wei D,Wan B,Wang JY

    更新日期:2012-11-01 00:00:00

  • Hepatic differentiation from embryonic stem cells in vitro.

    abstract:OBJECTIVE:To investigate an method for hepatic differentiation from embryonic stem cells (ES cells) in vitro and the resulting differentiation ratio, in order to develop a procedure for producing a new type of hepatocyte for hepatocyte replacement therapy in the treatment of liver failure. METHODS:ES cells from Balb/C...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Hu A,Cai J,Zheng Q,He X,Pan Y,Li L

    更新日期:2003-12-01 00:00:00

  • Effects of decline in renal function with age on the outcome of asymptomatic carotid plaque in healthy adults: a 5-year follow-up study.

    abstract:BACKGROUND:It has been long suggested that abnormal clinical factors in the body, such as dyslipidemia and diabetes, can affect the presence of atherosclerosis. However, few studies on the effect of factors within the normal range, such as the loss of renal function with age, on the prevalence of atherosclerosis are fe...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Jiang SM,Sun XF,Gu HX,Chen YS,Xi CS,Qiao X,Chen XM

    更新日期:2012-08-01 00:00:00

  • Impacts of smoking status on the clinical outcomes of coronary non-target lesions in patients with coronary heart disease: a single-center angiographic study.

    abstract:BACKGROUND:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events. This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions. METHODS:Consecutive patients with coronary heart disease who underwent two serial coronary ang...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000001024

    authors: Xu HB,Wang J,Chen JL,Guo C,Yuan JS,Duan X,Hu FH,Yang WX,Luo XL,Liu R,Cui JG,Liu SW,Gao XJ,Chun YS,Qiao SB

    更新日期:2020-10-05 00:00:00

  • Quantitative computed tomography measurement of cross-sectional area of small pulmonary vessels in asthmatic patients.

    abstract:BACKGROUND:Cross-sectional area (CSA) for small pulmonary vessels is considered a parameter of pulmonary vessel alterations in patients with chronic obstructive pulmonary disease. This study was to evaluate the correlation of CSA with airflow obstruction parameters in asthma. Furthermore, we aimed to measure the differ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000000367

    authors: Wang J,Li MJ,Chang C

    更新日期:2019-08-20 00:00:00

  • An epidemic of encephalitis and meningoencephalitis in children caused by echovirus type 30 in Shanghai.

    abstract::An outbreak of viral central nervous system infection occurred from May to September, 1991 in Shanghai, China. Totally 376 cases were admitted into our hospital, 54% with encephalitis and 46% with meningoencephalitis. Echovirus type 30 was isolated from CSF and stools of the patients. Only 3 of the patients were under...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang DM,Zhao GC,Zhuang SM,Zhang YC

    更新日期:1993-10-01 00:00:00

  • Diagnostic value of magnetocardiography in patients with coronary heart disease and in-stent restenosis.

    abstract:BACKGROUND:In-stent restenosis (ISR) has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted to explore the potential of magnetocardiography (MCG) in diagnosis of in-stent restenosis....

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Quan WW,Lu GP,Qi WH,Li YM,Shen Y,Yuan R

    更新日期:2008-01-05 00:00:00