P53 gene abnormalities in osteosarcoma.

abstract：BACKGROUND:There are more than 300 genetic loci that have been found to be related to hereditary hearing impairment (HHI), including 92 causative genes for nonsyndromic hearing loss, among which 34 genes are related to autosomal dominant nonsyndromic HHI (ADNSHHI). Traditional linkage analysis and candidate gene sequen...

journal_title：Chinese medical journal

authors： Wang HY,Zhao YL,Liu Q,Yuan H,Gao Y,Lan L,Yu L,Wang DY,Guan J,Wang QJ

更新日期：2015-12-20 00:00:00

abstract：BACKGROUND:The most common obstruction sites for obstructive sleep apnea hypopnea syndrome (OSAHS) are the oropharynx and the glossopharyx. The diagnosis of glossopharyngeal airway obstruction is difficult. The study aimed to assess the effect of upper airway reconstructive surgery for OSAHS based on polysomnography (P...

journal_title：Chinese medical journal

authors： Li SH,Wu DH,Bao JM,Shi HJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:One of the major causes of death in severe acute pancreatitis (SAP) is severe infection owing to bacterial translocation. Some clinical studies suggested that ecoimmunonutrition (EIN) as a new strategy had better treatment effect on SAP patients. But the experiment studies on the precise mechanism of the eff...

journal_title：Chinese medical journal

authors： Xu GF,Lu Z,Gao J,Li ZS,Gong YF

更新日期：2006-04-20 00:00:00

abstract：BACKGROUND:Angiopoietin-2 (Ang-2) is one of the critical regulators of tumor angiogenesis. Studies have shown a significant correlation of Ang-2 expression to tumor invasion and metastasis in various human cancers, but little is known about the serum Ang-2 (sAng-2) levels in esophageal squamous cell cancer (ESCC) and i...

journal_title：Chinese medical journal

authors： Zhou YZ,Fang XQ,Li H,Diao YT,Yang YF,Zhao DL,Wu K,Li HQ

更新日期：2007-07-20 00:00:00

abstract：OBJECTIVE:To study whether human umbilical cord blood CD34+ cells transduced with human aldehyde dehydrogenase class-1 (ALDH-1) and multidrug resistance gene (MDR1) have increases resistance to 4-Hydroperoxycyclo-phosphamide (4-HC) and P-glycoprotein effluxed drugs. METHODS:A bicistronic retroviral vector G1Na-ALDH1-I...

journal_title：Chinese medical journal

authors： Wang J,Chen Z,Xia X,Lu D,Xue J,Ruan C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Chronic liver disease causes aberrant formation of fibrous tissue that impedes normal liver function, ultimately resulting in liver cirrhosis. Iron uptake can occur within the hepatic parenchyma or within the various nodules that form in a cirrhotic liver, termed siderotic nodules (SN). We aimed to investiga...

journal_title：Chinese medical journal

authors： Tao R,You ZL,Zhang JQ,Dai YM,Zhou DQ,Cai P,Fan Y,Cui JG,Wang J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The aim of this research was to analyze the perioperative factors of regular hepatectomy and irregular hepatectomy. The superiority of the clinical application of the two methods was compared in the perioperative period. METHODS:From 1986 to 2011, 1798 patients underwent consecutive liver resections with re...

journal_title：Chinese medical journal

authors： Feng Z,Li H,Zhang J,Xu L,Xiao M,Huang Z,Zhang H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Endogenous hydrogen sulfide is a new neuromodulator which takes part in the regulation of central nervous system physiology and diseases. Whether endogenous hydrogen sulfide in the central nervous system regulates cardiovascular activity is not known. In the present study, we observed the hemodynamic changes...

journal_title：Chinese medical journal

authors： Ren YS,Wu SY,Wang XJ,Yu F,Zhao J,Tang CS,Ouyang JP,Geng B

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is a common pathogen in the lower respiratory tract of infants and children. Recent studies have shown that in adults, especially in the elderly population who have relatively weak immunity, lower respiratory tract infection is not uncommon. RSV was detected in 22% hospitali...

journal_title：Chinese medical journal

authors： Li W,Shen HH

更新日期：2007-01-05 00:00:00

abstract：BACKGROUND:Interferon (IFN) can inhibit human immunodeficiency virus type 1 (HIV-1) replication in vitro and in clinic. However, IFN therapy for HIV infection was limited by its moderate antiviral efficacy and its frequent adverse effects. In the present study we evaluated the anti-HIV efficacy of a novel synthesized s...

journal_title：Chinese medical journal

authors： Zhang W,Tong X,Nakasone T,Yue XT,Yamamoto N,Liu XY,Yang RG

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Cesarean scar pregnancy (CSP) is a very rare but life-threatening entity and there is no optimal management strategy. Here we report a successfully conservative treatment of CSP. METHODS:We retrospectively analyzed the clinical data of 54 women with CSP, who underwent uterine artery embolization between Jan...

journal_title：Chinese medical journal

authors： Cao S,Zhu L,Jin L,Gao J,Chen C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare soft tissue tumor, which is generally considered low-grade. To distinguish the tumor from other soft tissue lesions, we analyzed the clinicopathologic and ultrastructural features, immunophenotypes, and flow cytometric DNA ploidy of PHA...

journal_title：Chinese medical journal

authors： Ke Q,Erbolat,Zhang HY,Bu H,Li S,Shi DN,Yang GH,Chen HJ,Wei B

更新日期：2007-05-20 00:00:00

abstract：BACKGROUND:The safety and efficacy of drug-eluting stents (DES) implantation in unprotected left main (LM) bifurcation lesions has yet to be determined. The aim of the present report was to evaluate the long-term outcome following implantation of DES in unprotected LM bifurcation lesions. METHODS:We identified 70 cons...

journal_title：Chinese medical journal

authors： Ge L,Cosgrave J,Iakovou I,Qian JY,Agostoni P,Sangiorgi GM,Airoldi F,Michev I,Chieffo A,Corvaja N,Colombo A,Ge JB

更新日期：2007-04-05 00:00:00

abstract：BACKGROUND:CD4(+)CD25(+) regulatory T cells (Tregs) mediate immune suppression through cell-cell contact with surface molecules, particularly cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR), and transforming growth factor beta (TG...

journal_title：Chinese medical journal

authors： Zhang Q,Qian FH,Liu H,Zhou LF,Huang M,Zhang XL,Yin KS

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:To avoid the irritation of tendons and soft tissues as well as hardware-related problems, we designed an intramedullary fixation with bioabsorbable rods for the treatment of the metacarpal shaft fractures. METHODS:Five patients with nine shaft fractures of the fourth and fifth metacarpi were treated with in...

journal_title：Chinese medical journal

authors： Xiong G,Xiao ZR,Guo SG,Zheng W,Dai LF

更新日期：2015-11-05 00:00:00

abstract：OBJECTIVE:To investigate the regulation effect of protein kinase ERK on the activation of transcription factor STAT3 in response to IL-6 in the Sko-007 human myeloma cell line. METHODS:Electrophoretic mobility shift assay (EMSA) and immunoprecipitation (IP) were used to show the activation of STAT3 and ERK in Sko-007 ...

journal_title：Chinese medical journal

authors： Song L,Shen B,Li Y

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how ...

journal_title：Chinese medical journal

authors： Cao FJ,Zhang X,Liu T,Li XW,Malik M,Feng SQ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma especially prevailing among the natives of southern China. The regimen of concurrent chemoradiotherapy (CCRT) that include platinum and 5-fluorouracil (5-FU) is considered to be the standard treatment for NPC. However, its clinical use is limited by...

journal_title：Chinese medical journal

authors： Chen X,Hong Y,Feng J,Ye J,Zheng P,Guan X,You X,Song H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Despite the growing epidemic of heart failure (HF), there is limited data available to systematically compare non-cardiac comorbidities in the young-old, old-old, and oldest-old patients hospitalized for HF. The precise differences will add valuable information for better management of HF in elderly patients...

journal_title：Chinese medical journal

authors： Yang MX,An H,Fan XQ,Tao LY,Tu Q,Qin L,Zhang LF,Feng DP,Wang Y,Sun L,Gao S,Guan WZ,Zheng JG,Ren JY

更新日期：2019-12-20 00:00:00

abstract：OBJECTIVES:To study mitogen-activated protein kinase (MAPKs) activation in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) under the stimulation of IL-1 beta, and to elucidate the role of protein tyrosine kinase (PTK) in the activation of MAPKs. METHODS:Primary cultures of RA FLS were used. Western blo...

journal_title：Chinese medical journal

authors： Lu H,Sun T,Yao L,Zhang Y

更新日期：2000-10-01 00:00:00

abstract：: ...

journal_title：Chinese medical journal

authors： Zhang D,Han QX,Wu MH,Shen WJ,Yang XL,Guo J,Pan SK,Liu ZS,Tang L,Cai GY,Chen XM,Zhu HY

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:The Toll-like receptors (TLRs) represent a group of single-pass transmembrane receptors expressed on sentinel cells that are central to innate immune responses.The aim of this study was to investigate the presence of soluble TLRs in pleural effusions, and the diagnostic values of TLRs for pleural effusion wi...

journal_title：Chinese medical journal

authors： Yang HB,Xie KQ,Deng JM,Qin SM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:HIV-1 infected and immune-activated macrophages and microglia secrete neurotoxins, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which play major role in the neuronal death. It has been shown that different HIV-1 variants have varying abilities to elicit secretion of TNF-α by peripheral...

journal_title：Chinese medical journal

authors： Yan YF,Wang ZY,Pu SS,Wen HL,Huang T,Song YY,Xu HZ,Zhao L

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) and the effect of lipopolysaccharide (LPS) on their expression in cultured endothelial cells. METHODS:Total RNA was extracted from ECV304 cells and isolated human umbilical vein endothelial cells (HUVECs) exposed to ...

journal_title：Chinese medical journal

authors： Yang Q,Zhu P,Wang Z,Jiang J

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To assess the value of noninvasive three-dimensional computed tomographic angiography (3D-CTA) in preoperative detection of intracranial arteriovenous malformations (AVMs). METHODS:A prospective evaluation at a single institute over a 2-year period included 23 patients suspected of intracranial AVMs. All pat...

journal_title：Chinese medical journal

authors： Wu J,Chen X,Shi Y,Chen S

更新日期：2000-10-01 00:00:00

abstract：:With overall analysis of symptoms and signs of myasthenia gravis (MG) basing on "Pi (Spleen) Deficiency" [symbol: see text] theory and with years of our clinical experience in treating MG, we performed a pharmacological study of Astragalus saponins and Buzhong Yiqi Compound (Tonic granulae invigorating vital energy) i...

journal_title：Chinese medical journal

authors： Tu LH,Huang DR,Zhang RQ,Shen Q,Yu YY,Hong YF,Li GH

更新日期：1994-04-01 00:00:00

abstract：:Eighteen patients with acute hemorrhagic necrotizing pancreatitis who survived from operation were followed up for 12 to 43 months. Late complications including pancreatic external fistula, pseudocyst, hyperglycemia, etc were reviewed. The pancreatic juice was collected through endoscopic cannulation. The volume and H...

journal_title：Chinese medical journal

authors： Huang YT,Liu Q,Zhang BS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation. Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of atopic dermatitis (AD)-like GVHD and lichen planus (LP)-like GVHD. ...

journal_title：Chinese medical journal

authors： Li K,Mu ZL,Chen X,Wen GD,Zhao Y,Zhang JZ

更新日期：2017-06-20 00:00:00

abstract：:A series of 146 women taking compound quinestrol (CQ) was tested for glucose tolerance and insulin release to determine the effects of CQ on these parameters. 23 normal subjects (6 male and 17 female) and 12 diabetics (7 male and 5 female) were also tested and their results were compared with those from the CQ-taking...

journal_title：Chinese medical journal

authors： Zhu XX,He DH,Wang ZG,Chen JH,He WT,Qiu CL,Zhong XL

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Alzheimer disease (AD) is a neurodegenerative disease related to aging. At present, its pathological mechanisms remain unclear. Family members of the renin-angiotensin system (RAS) play a role in neuronal plasticity, as well as formation of learning and memory. In this study, we explore the effects of altere...

journal_title：Chinese medical journal

authors： Hou DR,Wang Y,Zhou L,Chen K,Tian Y,Song Z,Bao J,Yang QD

更新日期：2008-11-20 00:00:00