Abstract:
:A series of 146 women taking compound quinestrol (CQ) was tested for glucose tolerance and insulin release to determine the effects of CQ on these parameters. 23 normal subjects (6 male and 17 female) and 12 diabetics (7 male and 5 female) were also tested and their results were compared with those from the CQ-taking women. The curves of glucose tolerance, insulin release, release index during different phases, and the immunoreactive insulin-blood glucose (IRI-BG) distribution were compared. In this series, the insulin release curve, 45-minutes-after-release index, and IRI-BG distribution of subjects on CQ approximated those of normals, but differ dramatically from diabetic subjects. The glucose intolerance which accompanied the more active insulin reaction caused by CQ seems to gradually ameliorate or revert to normal after CQ withdrawal, a phenomenon which does not occur in true diabetics. Hence, the glucose intolerance caused by CQ is due to the drug's effect on the metabolism of carbohydrates or of insulin.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Zhu XX,He DH,Wang ZG,Chen JH,He WT,Qiu CL,Zhong XLsubject
Has Abstractpub_date
1980-09-01 00:00:00pages
651-8issue
9eissn
0366-6999issn
2542-5641journal_volume
93pub_type
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