A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance.

abstract：BACKGROUND:Chronic hepatic inflammation is characterized by the accumulation of lymphocytes as a consequence of increased recruitment from the blood and retention within the tissue at sites of infection. CXC chemokine ligand 16 (CXCL16) mRNA has been detected in both inflamed and normal liver tissues and is strongly up...

journal_title：Chinese medical journal

authors： Wang P,Kan QC,Yu ZJ,Li L,Pan X

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:As an X-linked recessive way, arginine vasopressin receptor 2 (AVPR2) gene mutation resulted in a hereditary disease - congenital nephrogenic diabetes insipidus (CNDI). We found a suspect clinical CNDI pedigree. In order to identify the genetic etiology, we performed the genetic analysis. METHODS:The clinic...

journal_title：Chinese medical journal

authors： Shen Y,Lai X,Xiao X,Li J,Yu R,Gao H,Zhang M

更新日期：2014-01-01 00:00:00

abstract：:Intraoperative coronary venography was performed in 24 patients before and after portal-azygos disconnection for portal hypertension. Before the procedure the portal vein was found to be communicated with cardial and esophageal veins by two pathways, i,e., from the esophageal and gastric branches of the coronary vein ...

journal_title：Chinese medical journal

authors： Zou ZS,Li JS,Li N,Liu FK

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridinium), a widely used herbicide that is structurally similar to the known dopaminergic neurotoxicant MPTP (1-methyl-1, 2, 3, 6-tetrahydropyridine), has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). Aging is an accepte...

journal_title：Chinese medical journal

authors： Li X,Yin J,Cheng CM,Sun JL,Li Z,Wu YL

更新日期：2005-08-20 00:00:00

abstract：BACKGROUND:Pancreatic beta-cell apoptosis induced by lipotoxicity, to a large extent, contributes to the progression of type 2 diabetes. To investigate the mechanism of free fatty acid induced apoptosis, we aimed to study the effects of palmitic acid (PA) on the apoptosis and peroxisome proliferator-activated receptor ...

journal_title：Chinese medical journal

authors： He TT,Cao XP,Chen RZ,Zhu XN,Wang XL,Li YB,Xiao HP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Endogenous hydrogen sulfide is a new neuromodulator which takes part in the regulation of central nervous system physiology and diseases. Whether endogenous hydrogen sulfide in the central nervous system regulates cardiovascular activity is not known. In the present study, we observed the hemodynamic changes...

journal_title：Chinese medical journal

authors： Ren YS,Wu SY,Wang XJ,Yu F,Zhao J,Tang CS,Ouyang JP,Geng B

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Among HIV-infected patients initiating antiretroviral therapy (ART), early changes in CD4+ T-cell subsets are well described. However, HIV-infected late presenters initiating treatment present with a suboptimal CD4+ T-cell reconstitution and remain at a higher risk for AIDS and non-AIDS events. Therefore, fa...

journal_title：Chinese medical journal

authors： Guo FP,Li YJ,Qiu ZF,Lv W,Han Y,Xie J,Li YL,Song XJ,Du SS,Mehraj V,Li TS,Routy JP

更新日期：2016-11-20 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small noncoding regulatory RNAs whose aberrant expression may be observed in many malignancies. However, few data are yet available on human primary medulloblastomas. This work aimed to identify that whether miRNAs would be aberrantly expressed in tumor tissues compared with non-tumoro...

journal_title：Chinese medical journal

authors： Liu W,Gong YH,Chao TF,Peng XZ,Yuan JG,Ma ZY,Jia G,Zhao JZ

更新日期：2009-10-20 00:00:00

abstract：OBJECTIVE:The P53 tumor suppressor gene shows the most frequent genetic alteration in human tumors. Mutation, deletion and rearrangement of P53 gene have been found in several types of neoplasm including osteosarcoma. The present study is to clarify the status of abnormalities of this gene in osteosarcoma in China. MA...

journal_title：Chinese medical journal

authors： Guo W,Wang X,Feng C

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:In-stent restenosis (ISR) has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted to explore the potential of magnetocardiography (MCG) in diagnosis of in-stent restenosis....

journal_title：Chinese medical journal

authors： Quan WW,Lu GP,Qi WH,Li YM,Shen Y,Yuan R

更新日期：2008-01-05 00:00:00

abstract：BACKGROUND:The continual and rapid development of techniques which are used for diagnosis and treatment makes management of colorectal cancer more difficult depending on single discipline. Colorectal cancer multidisciplinary team (MDT) working model is recommended by UK and other countries, but there is little informat...

journal_title：Chinese medical journal

authors： Ye YJ,Shen ZL,Sun XT,Wang ZF,Shen DH,Liu HJ,Zhang WL,Chen YL,Zhou J,Poston GJ,Wang S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The acetabular teardrop is often used to guide acetabular component placement in total hip arthroplasty (THA). Placing the lower acetabular component aspect at the same level as the lower teardrop edge was assumed to restore the hip center of rotation. Here we radiographically analyzed the relationship betwe...

journal_title：Chinese medical journal

authors： Lu Y,Cheng L,Guo W,Yu Q,Gao F,Zhang Q,Liu Z,Sun W,Shi Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In 2008, infants in some areas of China suffered from stones of the urinary system which were caused by melamine-contaminated milk formula. Most of the infants were asymptomatic, and a few suffered from acute renal failure induced by urinary obstruction by stones. This study aimed to assess the significance ...

journal_title：Chinese medical journal

authors： Shen Y,Liu XR,Zhang GJ,Zhou N

更新日期：2009-02-05 00:00:00

abstract：BACKGROUND:The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is consistently increasing. However, the pathology and prognosis of CSSNHL are still poorly understood. This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL. METHODS:One hundred and thir...

journal_title：Chinese medical journal

authors： Li FJ,Wang DY,Wang HY,Wang L,Yang FB,Lan L,Guan J,Yin ZF,Rosenhall U,Yu L,Hellstrom S,Xue XJ,Duan ML,Wang QJ

更新日期：2016-04-20 00:00:00

abstract：OBJECTIVE:To explore the relationship between apoptosis and spontaneous hypertension, and the effect of angiotensin converting enzyme (ACE) inhibitor on apoptosis. METHODS:Male spontaneously hypertensive rats (SHR) and normotensive control rats (WKY) at different ages were used, meanwhile, the treatment of SHR with ra...

journal_title：Chinese medical journal

authors： Peng L,Bradley CJ,Zulli A,Liu JJ

更新日期：1999-06-01 00:00:00

abstract：:By employing monoclonal phosphorylated neurofilaments antibody, we studied the abnormally pale-staining neurons in 3 cases of corticonigral degeneration by the avidin-biotin immunoperoxidase method. For comparison, the central chromatolysis in anterior horn cells secondary to cervical spine fracture and "ballooned" ne...

journal_title：Chinese medical journal

authors： Wang LN,Kowall NW,Richardson EP Jr

更新日期：1991-12-01 00:00:00

abstract：:Aluminium citrate (Al-cit) was shown to be biologically effective in preventing silicosis. A total of 917 cases selected from both engineering corps of railway and coalmines with stage 0 or 0+ by radiographs were studied. Cases were randomly divided into Al-cit treatment group and control group with continuing dust ex...

journal_title：Chinese medical journal

authors： Zou SQ,Liu H,Zhou YY,Su KQ,Qi KY,Guan SM,Liu SJ

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Although there were several clinical and experimental studies discussing the pathogenesis of dural arteriovenous fistula (DAVF), the pathological process leading to intracranial DAVF so far remains unknown. In this study, we investigated the expression of vascular growth factors in order to elucidate the pos...

journal_title：Chinese medical journal

authors： Tirakotai W,Bian LG,Bertalanffy H,Siegfried B,Sure U

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Most cardiac regenerative approaches can restore injured heart muscles. In this study, we investigated if fibrin sealant could help neonatal cardiomyocytes restore myocardial function in a rat model of myocardial infarction. METHODS:The left anterior descending artery in adult female Sprague-Dawley (SD) rat...

journal_title：Chinese medical journal

authors： Li YS,Gao BR

更新日期：2007-11-20 00:00:00

abstract：BACKGROUND:Patients with temporal lobe epilepsy (TLE) originating from different seizure onset zones had distinct electrophysiological characteristics and surgical outcomes. In this study, we aimed to investigate the relationship between the origin and prognosis of TLE, and the stereoelectroencephalography (SEEG) featu...

journal_title：Chinese medical journal

authors： Yan XM,Xu CP,Wang YP,Ma K,Yu T,Zhang XH,Zhang X,Gao RS,Zhang GJ,Li YJ

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Human urotensin II (UII) is the most potent mammalian vasoconstrictor identified so far. Our previous study showed that UII is a potent mitogen of airway smooth muscle cells (ASMC) inducing ASMC proliferation in a dose-dependent manner. The signal transduction pathway of UII mitogenic effect remains to be cl...

journal_title：Chinese medical journal

authors： Chen YH,Zhao MW,Yao WZ,Pang YZ,Tang CS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Susceptibility to coronary artery disease (CAD) and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and witho...

journal_title：Chinese medical journal

authors： Wang W,Peng WH,Lu L,Zhang RY,Zhang Q,Wang LJ,Chen QJ,Shen WF

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Because no data regarding the comparison of crush stenting with paclitaxel (PES) or sirolimus eluting stents (SES) for coronary bifurcate lesions have been reported, we compared the clinical outcomes of these two types of stents. METHODS:Two hundred and thirty patients with 242 bifurcate lesions were enroll...

journal_title：Chinese medical journal

authors： Chen SL,Zhang JJ,Ye F,Chen YD,Zhu ZS,Lin S,Tian NL,Liu ZZ,Fang WY,Sun XW,Hu DY,Kwan TW

更新日期：2008-03-20 00:00:00

abstract：OBJECTIVE:To review articles aiming to present an overview of the principles, progress, uses and limitations of laser speckle flowgraphy (LSFG) in posterior fundus circulation research. DATA SOURCES:The data used in this review was obtained mainly from the studies reported in PubMed using the key terms "laser speckle"...

journal_title：Chinese medical journal

authors： Zhang W,Kogure A,Yamamoto K,Hori S

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of alveolar macrophages (AMs), fibroblasts and interstitial cells on development of lung fibrosis, and the interactions among TGF-beta 1 PDGF and IGF-1 and these cytokines-effects on lung fibrosis. MATERIAL AND METHODS:Expressions of TGF-beta 1, PDGF and IGF-1 mRNA in the lung ce...

journal_title：Chinese medical journal

authors： Li H,He B,Que C,Weng B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Although previous reports had reported the use of temporary internal distraction as an aid to correct severe scoliosis, two-stage surgery strategy (less invasive internal distraction followed by posterior correction and instrumentation) has never been reported in the treatment of patients with severe spinal ...

journal_title：Chinese medical journal

authors： Tan R,Ma HS,Zou DW,Wu JG,Chen ZM,Zhou XF,Zhou JW

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Adenomyosis is a gynecological disorder with symptoms most presenting as dysmenorrhea and heavy menstrual bleeding. However, the presence of lower urinary tract symptoms (LUTS) among women with adenomyosis remains unclear. This study was designed to determine the prevalence of LUTS and factors related to the...

journal_title：Chinese medical journal

authors： Li T,Xu XX,Dai Y,Zhang JJ,Lang JH,Leng JH

更新日期：2017-07-05 00:00:00

abstract：OBJECTIVE:According to the characteristics of digital medicine and the demands of digitalized management in hospitals, we established a storage system that is affordable, highly expandable, and reliable. METHODS:The multi personal computer storage system (MPCSS) was constructed using hardware and software. The image d...

journal_title：Chinese medical journal

authors： Guo Q,Hao F,Duan X,Xie X,Liao W

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Some patients with pelvic organ prolapse may suffer from lower urinary tract symptoms (LUTS), especially stress urinary incontinence (SUI) named de novo SUI after pelvic floor reconstruction. This study aimed to investigate the incidence and risk factors of de novo SUI. METHODS:This is a nested case-control...

journal_title：Chinese medical journal

authors： Wang SY,Cao TT,Wang RZ,Yang X,Sun XL,Wang JL

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:Carotid stenosis is one of the common reasons for patients with ischemic stroke, and the two invasive options carotid endarterectomy (CEA) and carotid artery stenting (CAS) are the most popular treatments. But the relative efficacy and safety of the methods are not clear. METHODS:About 521 articles related ...

journal_title：Chinese medical journal

authors： Wang L,Liu XZ,Liu ZL,Lan FM,Shi WC,Liu J,Zhang JN

更新日期：2013-02-01 00:00:00