Abstract：
BACKGROUND:Because no data regarding the comparison of crush stenting with paclitaxel (PES) or sirolimus eluting stents (SES) for coronary bifurcate lesions have been reported, we compared the clinical outcomes of these two types of stents. METHODS:Two hundred and thirty patients with 242 bifurcate lesions were enrolled in a prospective, nonrandomized trial. Primary endpoints included myocardial infarction, cardiac death and target vessel revascularization at 8 months. RESULTS:All patients were followed up clinically and 82% angiographically at 8 months. Final kissing balloon inflation was performed in 72% in the PES and 75% in the SES groups (P>0.05). Compared to the SES group, PES group had a higher late loss and incidence of restenosis (P=0.04) in the prebifurcation vessel segment. The postbifurcation vessel segment in the PES group had a greater late loss ((0.7+/-0.6) mm vs (0.3+/-0.4) mm, P<0.001) and higher restenosis in the side branch (25.5% vs 15.6%, P=0.04) when compared to the SES group. There was significant difference of insegment restenosis in the entire main vessel between PES and SES groups (P=0.004). Target lesion revascularization was more frequently seen in the PES group as compared to the SES group (P=0.01). There was significant difference in the accumulative MACE between these two groups (P=0.01). The survival rate free from target lesion revascularization was significantly higher in the SES group when compared to the PES group (P<0.001). CONCLUSION:SES is superior to PES in reducing restenosis and target lesion revascularization by 8-month follow-up after crush stenting for bifurcate lesions.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Chen SL,Zhang JJ,Ye F,Chen YD,Zhu ZS,Lin S,Tian NL,Liu ZZ,Fang WY,Sun XW,Hu DY,Kwan TWsubject
Has Abstractpub_date
2008-03-20 00:00:00pages
528-33issue
6eissn
0366-6999issn
2542-5641journal_volume
121pub_type
杂志文章abstract：OBJECTIVE:To review the current research into Foxp3(+) regulatory T cells (Treg) cell surface molecules, plasticity of Treg cells and mechanisms of Treg cell suppression and to explore the possibilities to interfere in Treg cell suppression of anti-tumor immunity. DATA SOURCES:A literature search of all English articl...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To determine the in vitro expression of interleukin-12 (IL-12) and its effect on signal transducers and activators of transcription (STAT) signaling molecules in peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE). METHODS:Peripheral blood mononuclear cells in 39 pa...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:We assessed whether the CaNa2 EDTA could improve the accumulation of protoporphyrin IX (PpIX) and photosensitisation in HEp-2 cells as well as the depth of treatment of skin cancers on the topical 5-Aminolaevulinic acid (5-ALA) PDT. METHODS:HEp-2 cells were incubated with 5-ALA (0-1 mmol/L) and CaNa2EDTA (0...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Psoralen (PSO) was found cytotoxic against in vitro cultured human mucoepidermoid carcinoma cells of MEC-1 cell line. Its IC50 value was 8.6 micrograms/ml, and relative antitumor activity (RAA) 15. PSO suppressed DNA synthesis, damaged microvilli and cell membrane, and induced degeneration of mitochondria. It inhibite...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The heart is one of the most important oxygen delivery organs, and dysfunction significantly increases the mortality of the body. Hence, the heart has been studied in sepsis for over half a century. However, th...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.1097/CM9.0000000000000929
更新日期：2020-09-20 00:00:00
abstract：BACKGROUND:The importance of polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene for the prediction of the response to fluorouracil-based adjuvant chemotherapy in gastric cancer patients remains unclear. The aim of this study is to assess the predictive value of several polymorphisms of the MTHFR gene...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Cholesterol-lowering therapy with statins has been reported to reduce the morbidity and mortality of cardiovascular diseases. This study aimed to investigate the effects of combined application of extended-release niacin and atorvastatin on lipid profile modification and the risks of adverse events in patien...
journal_title：Chinese medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-07-20 00:00:00
abstract：OBJECTIVE:This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target. DATA SOURCES:This study was based on data obtained from PubMed and EMBASE up to June 30, 2015. Articles were selected using the following se...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：10.4103/0366-6999.167362
更新日期：2015-10-20 00:00:00
abstract：BACKGROUND:Peroxisome proliferator-activated receptor (PPAR) alpha is one of the subtypes of PPARs. It regulates metabolism of lipid and lipoprotein, as well as glucose homeostasis. In addition, PPARalpha influences cellular proliferation, inflammation, differentiation and apoptosis, which plays a vital role in cardiov...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-08-20 00:00:00
abstract：BACKGROUND:Bone morphogenetic protein (BMP) is a member of the superfamily of transforming growth factor-beta. Recent studies show that it is an indispensable factor in hematopoiesis. To better characterize the effect of recombinant human BMP (rhBMP)-2 in hematopoiesis, we set out to determine whether rhBMP-2 could pro...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2009-04-05 00:00:00
abstract：OBJECTIVE:To study the effect for albendazole therapy for alveolar echinococcus infection in gerbils and mice. METHODS:Mice and gerbils were infected of metacestode tissues by intraperitoneal (i.p.) transplantation and treated with albendazole-medicated feeds. The effects were evaluated by comparison of the treated an...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVE:Dermoscopy is a useful technique for improving the diagnostic accuracy of various types of skin disorders. In China, dermoscopy has been widely accepted, and domestic researchers have made tremendous progress in the field of dermoscopy. The main purpose of this review is to summarize the current status of der...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：10.1097/CM9.0000000000000396
更新日期：2019-09-05 00:00:00
abstract：BACKGROUND:In patients suffering from acute pancreatitis, the pathogenesis is not completely understood, and several recent studies in vitro suggested that heat shock proteins might play an important role in cell signaling. To investigate the possible role of extracellular heat shock protein 70 (Hsp70) in pancreatitis,...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-08-05 00:00:00
abstract：OBJECTIVE:This review discusses the current status and progress in studies on the roles of hydrogen sulfide (H(2)S) in regulation of neurotoxicity, neuroprotection, and neuromodulator, as well as its therapeutic potential for neurodegenerative disorders. DATA SOURCES:The data used in this review were mainly from Medli...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2011-11-01 00:00:00
abstract：:To understand the mechanism of hemorrhage, coagulation and fibrinolysis in epidemic hemorrhagic fever (EHF), thrombin time (TT), prothrombin time (PT), fibrinogen (FIG), the platelet count (PLAT), plasminogen (PLG), antithrombin-III (AT-III), fibrin-fibrinogen degraded products (FDP) and platelet functions of aggregat...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Candidal esophagitis is the primary infection among all digestive tract opportunistic ones in acquired immunodeficiency syndrome (AIDS) cases. X-ray manifestation reports of it are still rare. This study aimed to conduct a retrospective analysis on the X-ray data of 6 AIDS cases complicated with candidal eso...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Alpha 2A adrenergic receptor (AR) is a subtype of α2 AR belonging to G protein-coupled receptors, and exerts a variety of biological effects. Recent studies have demonstrated that the α2A AR activation was closely related with inflammatory reaction. The present study aimed to investigate the influence of α2A...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
abstract：Background:The effect of maternal weights on the risk of iron deficiency anemia (IDA) during pregnancy remains unclear. The study aimed to investigate the association between maternal weight indicators and IDA during pregnancy. Methods:We conducted a cohort study to examine the association between maternal weight indi...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.244109
更新日期：2018-11-05 00:00:00
abstract：OBJECTIVE:To study the effect of pericardial devascularization combined with Latarjet's innervation on portal hypertension. METHODS:Forty-eight patients undergoing pericardial devascularization combined with Latarjet's innervation were compared with 57 patients with devascularization. Clinical results were evaluated b...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Temporary arterial occlusion during intracranial aneurysm surgery is a safe and effective modality. It is not only an emergency measure for controlling aneurysmal bleeding, but also a helpful means for accurate and meticulous dissection and clipping of an intracranial aneurysm with the advantage of minimizing the chan...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:The myocardial ATP sensitive potassium channel (K(ATP) channel) has been known for more than two decades, the properties of this channel have been intensively investigated, especially the myocardial protection effect by opening this channel. Numerous studies, including hypothermic, using K(ATP) agonists to a...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2006-10-20 00:00:00
abstract：BACKGROUND:Screening for amblyopia at earliest is important for early treatment and better prognosis. This study aimed to evaluate the validity of uncorrected distant and near visual acuity (VA) and stereoacuity for screening amblyopia in grade-1 students in primary school in central China. METHODS:By stratified clust...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules (15d-PGJ2-NC...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.198924
更新日期：2017-02-05 00:00:00
abstract：OBJECTIVE:To clarify whether genetic variants of the renin-angiotensin system (RAS) contribute to the development of diabetic nephropathy (DN) in the Chinese. METHODS:Totally 173 Chinese subjects of Han nationality from Shanghai were classified into! control, DN (-) and DN (+) groups. The latter was subdivided accordi...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Previous studies have different viewpoints about the clinical impact of methicillin resistance on mortality of hospital-acquired bloodstream infection (BSI) patients with Staphylococcus aureus (S. aureus). The objective of this study was to investigate the mortality of hospital-acquired BSI with S. aureus in...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To examine the effect of selective head cooling (SHC) on brain cell membrane activity involving ATPase, phospholipase A2, content of total membrane phospholipids during postischemic reperfusion, so as to elucidate the possible underlying mechanism on resuscitating effect of SHC. MATERIALS AND METHODS:Complet...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:The acetabular teardrop is often used to guide acetabular component placement in total hip arthroplasty (THA). Placing the lower acetabular component aspect at the same level as the lower teardrop edge was assumed to restore the hip center of rotation. Here we radiographically analyzed the relationship betwe...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Septicemia and inflammation-mediated septic shock caused by Vibrio vulnificus (VV) is strongly associated with chronic liver disease. This study examined the effects of antimicrobial therapy on expression of hepatic toll-like receptors and inflammatory cytokines in rats with alcohol-induced liver disease com...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2009-08-20 00:00:00
abstract：OBJECTIVE:To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig). METHODS:We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVE:To measure serum 7S collagen (7S-C) and type VI collagen (VI-C) levels by radioimmunoassay (RIA) in Chinese patients with various liver disorders and in CCl4-treated SD rats, and to investigate the significance of the elevated levels of serum 7S-C and VI-C. METHODS:Serum 7S-C and VI-C levels were measured in...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
