当前位置： SCI文献检索 > CHINESE MEDICAL JOURNAL期刊下所有文献 > Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss.

Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss.

Abstract：

BACKGROUND:The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is consistently increasing. However, the pathology and prognosis of CSSNHL are still poorly understood. This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL. METHODS:One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this study. These patients were analyzed for clinical characteristics, audiological characteristics, laboratory examinations, and prognostic factors. RESULTS:Among the 136 patients (151 ears), 121 patients (121 ears, 80.1%) were diagnosed with unilaterally CSSNHL, and 15 patients (30 ears, 19.9%) with bilateral CSSNHL. The complete recovery rate of CSSNHL was 9.3%, and the overall recovery rate was 37.7%. We found that initial degree of hearing loss, onset of treatment, tinnitus, the ascending type audiogram, gender, side of hearing loss, the recorded auditory brainstem response (ABR), and distortion product otoacoustic emissions (DPOAEs) had prognostic significance. Age, ear fullness, and vertigo had no significant correlation with recovery. Furthermore, the relevant blood tests showed 30.8% of the children had abnormal white blood cell (WBC) counts, 22.1% had elevated homocysteine levels, 65.8% had high alkaline phosphatase (ALP), 33.8% had high IgE antibody levels, and 86.1% had positive cytomegalovirus (CMV) IgG antibodies. CONCLUSIONS:CSSNHL commonly occurs unilaterally and results in severe hearing loss. Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery, while positive prognostic factors include tinnitus, gender, the ascending type audiogram, early treatment, identifiable ABR waves, and DPOAEs. Age, vertigo, and ear fullness are not correlated with the recovery. Some serologic indicators, including the level of WBC, platelet, homocysteine, ALP, positive CMV IgG antibody, fibrinogen, and some immunologic indicators, are closely related to CSSNHL.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Li FJ,Wang DY,Wang HY,Wang L,Yang FB,Lan L,Guan J,Yin ZF,Rosenhall U,Yu L,Hellstrom S,Xue XJ,Duan ML,Wang QJ

doi

10.4103/0366-6999.179791

subject

Has Abstract

pub_date

2016-04-20 00:00:00

pages

946-52

issue

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2016_129_8_946_179791

journal_volume

129

pub_type

杂志文章

在线工具

Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss.