Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis.

Abstract:

OBJECTIVE:Sepsis remains a leading cause of death in many Intensive Care Units worldwide. Immunosuppression has been a primary focus of sepsis research as a key pathophysiological mechanism. Given the important role of the negative costimulatory molecules programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) in the occurrence of immunosuppression during sepsis, we reviewed literatures related to the PD-1/PD-L1 pathway to examine its potential as a new target for sepsis treatment. DATA SOURCES:Studies of the association between PD-1/PD-L1 and sepsis published up to January 31, 2017, were obtained by searching the PubMed database. STUDY SELECTION:English language studies, including those based on animal models, clinical research, and reviews, with data related to PD-1/PD-L1 and sepsis, were evaluated. RESULTS:Immunomodulatory therapeutics could reverse the deactivation of immune cells caused by sepsis and restore immune cell activation and function. Blockade of the PD-1/PD-L1 pathway could reduce the exhaustion of T-cells and enhance the proliferation and activation of T-cells. CONCLUSIONS:The anti-PD-1/PD-L1 pathway shows promise as a new target for sepsis treatment. This review provides a basis for clinical trials and future studies aimed at revaluating the efficacy and safety of this targeted approach.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Liu Q,Li CS

doi

10.4103/0366-6999.204113

subject

Has Abstract

pub_date

2017-04-20 00:00:00

pages

986-992

issue

8

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2017_130_8_986_204113

journal_volume

130

pub_type

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