Abstract:
BACKGROUND:Lidocaine and ropivacaine are often combined in clinical practice to obtain a rapid onset and a prolonged duration of action. However, the systemic toxicity of their mixture at different concentrations is unclear. This study aimed to compare the systemic toxicity of the mixture of ropivacaine and lidocaine at different concentrations when administered intravenously in rats. METHODS:Forty-eight male Wistar rats were randomly divided into 4 groups (n = 12 each): 0.5% ropivacaine (group I); 1.0% ropivacaine and 1.0% lidocaine mixture (group II); 1.0% ropivacaine and 2.0% lidocaine mixture (group III); and 1.0% lidocaine (group IV). Local anesthetics were infused at a constant rate until cardiac arrest. Electrocardiogram, electroencephalogram and arterial blood pressure were continuously monitored. The onset of toxic manifestations (seizure, dysrhythmia, and cardiac arrest) was recorded, and then the doses of local anesthetics were calculated. Arterial blood samples were drawn for the determination of local anesthetics concentrations by high-performance liquid chromatography. RESULTS:The onset of dysrhythmia was later significantly in group IV than in group I, group II, and group III (P < 0.01), but there was no significant difference in these groups (P > 0.05). The onset of seizure, cardiac arrest in group I ((9.2 + or - 1.0) min, (37.0 + or - 3.0) min) was similar to that in group II ((9.1 + or - 0.9) min, (35.0 + or - 4.0) min) (P > 0.05), but both were later in group III ((7.5 + or - 0.7) min, (28.0 + or - 3.0) min) (P < 0.05). The onset of each toxic manifestation was significantly later in group IV than in group I (P < 0.01). The plasma concentrations of the lidocaine-alone group at the onset of dysrhythmia (DYS), cardiac arrest (CA) ((41.2 + or - 6.8) min, (59.0 + or - 9.0) min) were higher than those of the ropivacaine alone group ((20.5 + or - 3.8) min, (38.0 + or - 8.0) min) (P < 0.05). The plasma concentrations of ropivacaine inducing toxic manifestation were not significantly different among groups I, II, and III (P > 0.05). CONCLUSIONS:The systemic toxicity of the mixture of 1.0% ropivacaine and 2.0% lidocaine is the greatest while that of 1.0% lidocaine is the least. However, the systemic toxicity of the mixture of 1.0% ropivacaine and 1.0% lidocaine is similar to that of 0.5% ropivacaine alone.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Wan QX,Bo YL,Li HB,Li WZsubject
Has Abstractpub_date
2010-01-05 00:00:00pages
79-83issue
1eissn
0366-6999issn
2542-5641journal_volume
123pub_type
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.4103/0366-6999.246079
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更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Ophthalmic gel has been developed to increase the drug concentration in aqueous humor and to retard the loss of drug from the conjunctival sac. The research was to compare the drug concentration in aqueous humor of cataract patients administered 0.3% gatifloxacin ophthalmic gel with that in patients administ...
journal_title:Chinese medical journal
pub_type: 杂志文章,随机对照试验
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更新日期:2010-08-05 00:00:00
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章
doi:10.4103/0366-6999.243558
更新日期:2018-10-20 00:00:00
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pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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更新日期:1999-07-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00
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