Abstract：
BACKGROUND:Ophthalmic gel has been developed to increase the drug concentration in aqueous humor and to retard the loss of drug from the conjunctival sac. The research was to compare the drug concentration in aqueous humor of cataract patients administered 0.3% gatifloxacin ophthalmic gel with that in patients administered 0.3% gatifloxacin ophthalmic solution. METHODS:Ninety-six patients with cataract (96 eyes) were randomly assigned to 8 groups. The patients in groups 1-4 received topical gatifloxacin 0.3% ophthalmic gel and those in groups 5-8 received gatifloxacin 0.3% ophthalmic solution. The dose regimen was 1 drop, 4 times a day for 3 consecutive days prior to cataract surgery. On the day of surgery, 1 drop was applied at 15, 30, 60 or 120 minutes before commencement of cataract surgery in groups 1 and 5, groups 2 and 6, groups 3 and 7, and groups 4 and 8, respectively. Aqueous humor was extracted during the cataract surgery for the analysis of gatifloxacin concentration.. RESULTS:The concentrations of gatifloxacin in aqueous humor were (0.24 +/- 0.25) microg/ml, (1.11 +/- 0.74) microg/ml, (2.32 +/- 2.01) microg/ml and (1.85 +/- 1.14) microg/ml in groups 1 to 4, and (0.16 +/- 0.25) microg/ml, (0.31 +/- 0.24) microg/ml, (0.75 +/- 0.28) microg/ml and (0.33 +/- 0.22) microg/ml in groups 5 to 8, respectively. Patients receiving gatifloxacin ophthalmic gel showed greater mean values of gatifloxacin concentration in aqueous humor than those receiving gatifloxacin solution, and such differences were significant with P < 0.05 for all comparisons except that between groups 1 and 5. CONCLUSION:Topical gatifloxacin ophthalmic gel can attain significantly greater drug concentrations in human aqueous humor than gatifloxacin ophthalmic solution.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Liu X,Wang NL,Wang YL,Ma C,Ma L,Gao LX,Huang YX,Xiong SH,Wang Ksubject
Has Abstractpub_date
2010-08-05 00:00:00pages
2105-10issue
15eissn
0366-6999issn
2542-5641journal_volume
123pub_type
杂志文章,随机对照试验abstract：Background::Localized macular edema and retinal nerve fiber layer (RNFL) thinning have been reported shortly after laser in situ keratomileusis (LASIK) in adults. However, it is still unclear how LASIK affects the retina of children. This study aimed to investigate the macular retina and RNFL thickness in children with...
journal_title：Chinese medical journal
pub_type： 杂志文章
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journal_title：Chinese medical journal
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pub_type： 杂志文章
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journal_title：Chinese medical journal
pub_type： 杂志文章
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pub_type： 杂志文章
doi：
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doi：
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doi：10.4103/0366-6999.244110
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：
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doi：
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pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
doi：
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pub_type： 杂志文章
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更新日期：2018-09-05 00:00:00
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pub_type： 杂志文章
doi：
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