The pathogenesis of Chlamydia pneumoniae-type pneumonitis in mice.

abstract：BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease. STK11/LKB1 gene germline mutations have been identified as responsible for PJS. In our study, we investigated the molecular basis of PJS and evaluated correlation between the STK11 mutations and the Chinese population. METHODS:We col...

journal_title：Chinese medical journal

authors： Zuo YG,Xu KJ,Su B,Ho MG,Liu YH

更新日期：2007-07-05 00:00:00

abstract：BACKGROUND:There are more than 300 genetic loci that have been found to be related to hereditary hearing impairment (HHI), including 92 causative genes for nonsyndromic hearing loss, among which 34 genes are related to autosomal dominant nonsyndromic HHI (ADNSHHI). Traditional linkage analysis and candidate gene sequen...

journal_title：Chinese medical journal

authors： Wang HY,Zhao YL,Liu Q,Yuan H,Gao Y,Lan L,Yu L,Wang DY,Guan J,Wang QJ

更新日期：2015-12-20 00:00:00

abstract：OBJECTIVE:5-Fluorouracil (5-FU)-based combination therapies are standard treatments for gastrointestinal cancer, where the modulation of autophagy is becoming increasingly important in offering effective treatment for patients in clinical practice. This review focuses on the role of autophagy in 5-FU-induced tumor supp...

journal_title：Chinese medical journal

authors： Tang JC,Feng YL,Liang X,Cai XJ

更新日期：2016-02-20 00:00:00

abstract：OBJECTIVE:To explore the characteristics of Helicobacter pylori (H. pylori) antigen in serum and to evaluate its clinical diagnostic value. METHODS:Enzyme-linked immunosorbant assay (ELISA) was developed to detect the soluble H. pylori antigen (S-Hp) and circulatory specific H. pylori antigen immunocomplexes (Hp-IC) i...

journal_title：Chinese medical journal

authors： Zhu Y,Lin J,Li D,Du Q,Qian K,Wu Q,Zheng S

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common condition, which affects not only the quality of life of patients but also their prognosis. The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the gluco...

journal_title：Chinese medical journal

authors： Xiao Y,Su L,Han B,Zhang X,Xie L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Caspases are important in the signaling pathway of cellular apoptosis. Caspase-3 protein expression has been shown to increase and parallel to neuronal apoptosis in retinal ischemia injury. This study was to determine whether caspase-1 is involved in neuronal cell death or in retinal ischemia and reperfusion...

journal_title：Chinese medical journal

authors： Zheng GY,Zhang C,Li ZG

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The anterior cruciate ligament (ACL) is one of the most commonly injured knee ligaments. Even following ACL reconstruction, significant articular cartilage degeneration can be observed and most patients suffer from premature osteoarthritis. Articular cartilage degeneration and osteoarthritis development afte...

journal_title：Chinese medical journal

authors： Shi DL,Wang YB,Ai ZS

更新日期：2010-11-01 00:00:00

abstract：:Eighteen patients with acute hemorrhagic necrotizing pancreatitis who survived from operation were followed up for 12 to 43 months. Late complications including pancreatic external fistula, pseudocyst, hyperglycemia, etc were reviewed. The pancreatic juice was collected through endoscopic cannulation. The volume and H...

journal_title：Chinese medical journal

authors： Huang YT,Liu Q,Zhang BS

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To investigate whether pretreatment with repeated electroacupuncture (EA) at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats. METHODS:Thirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consis...

journal_title：Chinese medical journal

authors： Xiong L,Lu Z,Hou L,Zheng H,Zhu Z,Wang Q,Chen S

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Polymorphism in vitamin D receptor (VDR) gene has been reported to play a major role in variations for genetic regulation of bone mass. Its role within various ethnic populations is not clear. The purpose of this study was to determine the frequencies of VDR genotypes in the Han and Uygur nationalities in Chi...

journal_title：Chinese medical journal

authors： Zhang H,Tao G,Wu Q,Liu J,Gao Y,Chen R,Leng X

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether PreS1 antigen and/or anti-PreS1 antibody in serum might have some significance different from routine hepatitis B virus (HBV) markers in hepatitis B virus infection. METHODS:Forty-six acute hepatitis B patients and 377 chronic persistent hepatitis patients were examined to assess the c...

journal_title：Chinese medical journal

authors： Mi Z,Feng F,Zhang X,Lian Z,Wang H,Tong Y

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:T8590C polymorphism of CYP4A11 has been associated with hypertension, though with conflicting results. The aim of this study was to quantitatively summarize the evidence for CYP4A11 T8590C polymorphism and hypertension risk. METHODS:Electronic search of PubMed and the Chinese Biomedicine database was conduc...

journal_title：Chinese medical journal

authors： Jiang Y,Hou J,Zhang Q,Tang W,Luo Y

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To characterize the mRNA expression of CXC chemokine IL-8, CC chemokine monocyte chemothractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), and a newly defined DC chemokine DC-CK1 as well as the expression of IL-8 receptor, MCP-1 receptor and RANTES receptor i...

journal_title：Chinese medical journal

authors： Zhu K,Shen Q,Ulrich M,Zheng M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The emergence of bacterial resistance to commonly used antibiotics, such as macrolides, is complicating the management of respiratory tract infections (RTIs). Telithromycin, a ketolide antimicrobial structurally related to macrolides, is approved for the treatment of community-acquired RTIs, and shows lower ...

journal_title：Chinese medical journal

authors： Li XM,Wang FC,Yang F,Jin YH

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To choose one optimal extrinsic positive end-expiratory pressure (PEEPe) for ventilated patients with chronic obstructive pulmonary disease (COPD) and to compare two methods for choosing the optimal level of PEEPe. METHODS:Ten ventilated patients with COPD were included in the study. First, static intrinsic ...

journal_title：Chinese medical journal

authors： Kong W,Wang C,Yang Y,Huang K,Jiang C

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To present a special case with the karyotype and molecular marker of acute myeloid leukemia (AML)-M2 who was induced to complete remission by all-trans retinoic acid (ATRA) alone. METHODS:A recently hospitalized young female patient with acute leukemia was initially diagnosed as M3 subtype based on morpholog...

journal_title：Chinese medical journal

authors： Chen Z,Wang Y,Wang W,Gong J,Xue Y

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Mirizzi syndrome is often difficult to diagnose before surgery, and is often accompanied by extensive adhesions in the cystohepatic (Calot's) triangle and the difficulty of separating tissue can lead to bile duct injury and other intraoperative and postoperative complications. The aim of this study is to inv...

journal_title：Chinese medical journal

authors： Li B,Li X,Zhou WC,He MY,Meng WB,Zhang L,Li YM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Chimerism analysis is an important tool for the surveillance of post-transplant engraftment. It offers the possibility of identifying impending graft rejection and recurrence of underlying malignant or non-malignant disease. Here we investigated the quantitative chimerism kinetics of 21 relapsed leukemia pat...

journal_title：Chinese medical journal

authors： Qin XY,Li GX,Qin YZ,Wang Y,Wang FR,Liu DH,Xu LP,Chen H,Han W,Wang JZ,Zhang XH,Li JL,Li LD,Liu KY,Huang XJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Intravertebral and general anesthesia (GA) are two main anesthesia approaches but both have defects. This study was aimed to evaluate the effect of subarachnoid anesthesia combined with propofol target-controlled infusion (TCI) on blood loss and transfusion for total hip arthroplasty (THA) in elderly patient...

journal_title：Chinese medical journal

authors： Xu CS,Qu XD,Qu ZJ,Wang G,Wang HJ

更新日期：2020-03-20 00:00:00

abstract：OBJECTIVE:The management strategies after acute myocardial infarction (AMI) have been evolving from simple supportive treatment to various protocols of thrombolytic therapies, and then to mechanical revascularization by balloon angioplasty in recent years. However, controversies still exist between which is the best tr...

journal_title：Chinese medical journal

authors： Lee SW,Chan HW,Lam L

更新日期：1997-06-01 00:00:00

abstract：:This review of recent literature presents new concepts to evaluate radiation hormesis in cancer mortality. Using these interpretations cancer mortality rates were found to be significantly reduced following whole body exposure to low doses of either acute or chronic irradiation. The threshold dose, the zero equivalent...

journal_title：Chinese medical journal

authors： Lukey TD

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The baseline characteristics of patients in a multinational trial are possibly related to cardiovascular outcome. This study compared the baseline characteristics of patients recruited in China with those recruited in other countries. METHODS:A total of 508 Chinese hypertensive men and 728 women over the ag...

journal_title：Chinese medical journal

authors： Liu LS,Wang JG,Shu-Ping M,Wang W,Lu FH,Zhang LQ,Banya W,Peters R,Beckett N,Fletcher A,Bulpitt CJ

更新日期：2008-08-20 00:00:00

abstract：BACKGROUND:Studies on selected patients undergoing off-pump versus on-pump coronary artery bypass surgery have produced inconsistent results, especially in patients with multiple coronary artery disease. This study compared the clinical results of on-pump and off-pump coronary bypass surgery in patients with triple-ves...

journal_title：Chinese medical journal

authors： Chen X,Xu M,Shi HW,Mu XW,Chen ZQ,Qiu ZB

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive disease associated with a cellular inflammatory response mostly concerned with cigarette smoking. Chemokine receptors CCR1/5 play an important role in the inflammatory cells recruitment in the lung of COPD patients. The aim of this study was to de...

journal_title：Chinese medical journal

authors： Wang F,He B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Antiplatelet therapy (APT) was prevalently being used in the prevention of vascular disease, but the influence of prior APT on the prognosis of patients with intracerebral hemorrhage (ICH) remains controversial. This meta-analysis was to explore the effects of prior APT on the prognosis of patients with prim...

journal_title：Chinese medical journal

authors： Yu HH,Pan C,Tang YX,Liu N,Zhang P,Hu Y,Zhang Y,Wu Q,Deng H,Li GG,Li YY,Nie H,Tang ZP

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Low molecular weight heparin (LMWH), as one of anticoagulant drugs, has been used for the treatment of chronic obstructive pulmonary disease (COPD) with prethrombotic state, but the specific use time is unclear. The aim of the study is to observe the effect of LMWH at two different periods of prethrombotic s...

journal_title：Chinese medical journal

authors： Wang Y,Sun N,Cheng Z,Tong L

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To review the relationship between personal behavior and cultural factors and reproductive tract infections (RTIs). METHODS:An English-language literature search using MEDLINE (1994-1998), Social Science Index (1994-1998), and informal discovery. Any original researches and reviews related to RTIs' epidemiol...

journal_title：Chinese medical journal

authors： Guo S

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Generalized glucocorticoid resistance syndrome is a rare familial or sporadic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. This syndrome is partially caused by mutations in the human glucocorticoid receptor (hGR) gene. The clinical spectrum of generalized g...

journal_title：Chinese medical journal

authors： Zhu HJ,Dai YF,Wang O,Li M,Lu L,Zhao WG,Xing XP,Pan H,Li NS,Gong FY

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Mitochondrial diseases are a group of energy metabolic disorders with multisystem involvements. Variable clinical features present a major challenge in pediatric diagnoses. We summarized the clinical spectrum of m.3243A>G mutation in Chinese pediatric patients, to define the common clinical manifestations an...

journal_title：Chinese medical journal

authors： Xia CY,Liu Y,Liu H,Zhang YC,Ma YN,Qi Y

更新日期：2016-08-20 00:00:00

abstract：OBJECTIVE:To explore the immune promotion mechanism of retinoic acid (RA). METHODS:Reverse Transcription-Polymerase chain reaction (RT-PCR) was used to detect the gene expression of insulin like growth factor I (IGF-I) and IGF receptors (IGF-IR and IGF-IIR) in vitro, and their regulation by RA in human cord blood lymp...

journal_title：Chinese medical journal

authors： Yang Y,Wang W,Su Y

更新日期：2001-02-01 00:00:00