Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice.

abstract：OBJECTIVE:To investigate the role of bax in a vincristine (VCR)-induced multidrug-resistant (MDR) human gastric cancer cell line, SGC7901/VCR, in which the Bax protein expression level was significantly lower compared with that in parent cells. METHODS:A bax eukaryotic expression vector was constructed and transfected...

journal_title：Chinese medical journal

authors： Zhao Y,Xiao B,Chen B,Qiao T,Fan D

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Although the use of expanded-criteria donors (ECDs) alleviates the problem of organ shortage, it significantly increases the incidence of delayed graft function (DGF). DGF is a common complication after kidney transplantation; however, the effect of DGF on graft loss is uncertain based on the published liter...

journal_title：Chinese medical journal

authors： Han F,Lin MZ,Zhou HL,Li H,Sun QP,Huang ZY,Hong LQ,Wang G,Cai RM,Sun QQ

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:It has been widely demonstrated that endothelial progenitor cells are involved in several diseases and that they have therapeutic implications. In order to define the altered pulmonary vascular homeostasis in chronic obstructive pulmonary disease, we sought to observe the level and functions of circulating e...

journal_title：Chinese medical journal

authors： Yang Y,Gan Y,Cao J,Chen Y,He ZH,Luo H,Cai S,Xiang XD,Zhou R,Chen P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Over the years, the mechanical ventilation (MV) strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation (LPV), among brain-injured patients in China. METHODS:This study was a multicenter, 1-day, cross-sectional study in...

journal_title：Chinese medical journal

authors： Luo XY,Hu YH,Cao XY,Kang Y,Liu LP,Wang SH,Yu RG,Yu XY,Zhang X,Li BS,Ma ZX,Weng YB,Zhang H,Chen DC,Chen W,Chen WJ,Chen XM,Du B,Duan ML,Hu J,Huang YF,Jia GJ,Li LH,Liang YM,Qin BY,Wang XD,Xiong J,Yan LM

更新日期：2016-07-20 00:00:00

abstract：OBJECTIVE:To study if the functions of C gene and its promotor are related to the pathogenesis of hepatitis B and to describe their hot spot mutations in Chinese patients. DATA SOURCES:We have studied this subject in recent years. A mini-review is based on some unpublished works. DATA SELECTION:The sequence data of C...

journal_title：Chinese medical journal

authors： Luo K

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Hamstring (HS) autograft and bone-patellar tendon-bone allograft are the most common choice for reconstruction of anterior cruciate ligament (ACL). There was a little report about the clinical outcome and difference of arthroscopic ACL reconstruction using allograft and autograft. This study aimed to compare...

journal_title：Chinese medical journal

authors： Jia YH,Sun PF

更新日期：2015-12-05 00:00:00

abstract：OBJECTIVE:To investigate the synergistic antitumor effects of combined use of p14ARF gene and 5-fluorouracil (5-Fu) in pancreatic cancer. METHODS:A human pancreatic cancer cell line PC-3 was transfected with lipofectin-mediated recombinant p14ARF gene, and was then administered with 5-Fu. Cell growth, morphological ch...

journal_title：Chinese medical journal

authors： Zhang Q,Ni Q,Gan J,Shen Z,Luo J,Jin C,Zhang N,Zhang Y

更新日期：2003-08-01 00:00:00

abstract：:Renal angiomyolipoma is a type of benign tumor that occurs sporadically in addition to being associated with tuberous sclerosis. Preoperative embolization of large tumors is important to avoid excessive blood loss during surgery. We reported a patient with a 5505-g giant renal angiomyolipoma in a solitary kidney. The ...

journal_title：Chinese medical journal

authors： Shen WH,Pan JH,Yan JN,Chen ZW,Zhou ZS,Lu GS,Li WB

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Mesenteric artery thrombosis is prone to occur at specific arterial regions with different fluid flow patterns, yet mechanistic links between blood flow and vascular function remain unclear. This study aimd to investigate the role of blood flow in regulation of vascular function and gene expression in rats. ...

journal_title：Chinese medical journal

authors： Xia S,Deng CS

更新日期：2009-05-20 00:00:00

abstract：OBJECTIVE:To investigate the role of a potential diabetes-related mitochondrial region, which includes two previously reported mutations, 3243A-->G and 3316G-->A, in Chinese patients with adult-onset type 2 diabetes. METHODS:A total of 277 patients and 241 normal subjects were recruited for the study. Mitochondrial nt...

journal_title：Chinese medical journal

authors： Yang T,Lam CW,Tsang MW,Tong SF,Kam GY,Chan LY,Poon PM,Wu X,Pang CP

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To investigate the distribution and clonality of the T-cell receptor (TCR) V beta repertoire in chronic graft versus host disease (cGVHD). METHODS:The complementarity determining region 3 (CDR3) of the TCR beta gene with 24 variable regions was amplified in peripheral blood mononuclear cells drawn from one c...

journal_title：Chinese medical journal

authors： Li Y,Du X,Xu M,Zhang T,Yang L,Chen S

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Sunitinib has been proved an effective new option for treatment of metastatic renal cell carcinoma (mRCC). Analysis of clinical data of 22 patients, who were exposed to sunitinib for at least 1 year, was conducted to evaluate the long-term efficacy and safety of sunitinib for the treatment of mRCC. METHODS:...

journal_title：Chinese medical journal

authors： Zhang CJ,Zhao PJ,Li XS,Zhao J,Huang LH,Song Y,Gong K,Shen C,Yu W,Song G,Zhao Z,Zhang Z,Zhang Q,He ZS,Jin J,Zhou LQ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Clostridium difficile-associated diarrhea (CDAD) is a major public health problem because of significant morbidity and mortality, and many clinicians pay attention to Lactobacillus as a potentially effective treatment. The purpose of this meta-analysis was to evaluate the efficacy of Lactobacillus in the pre...

journal_title：Chinese medical journal

authors： Wu ZJ,DU X,Zheng J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:In central precocious puberty (CPP), the pulse secretion and release of gonadotropin-releasing hormone (GnRH) are increased due to early activation of the hypothalamic-pituitary-gonadal axis, resulting in developmental abnormalities with gonadal development and appearance of secondary sexual characteristics....

journal_title：Chinese medical journal

authors： Li WJ,Gong CX,Guo MJ,Xing J,Li T,Song WH,Luo XP,Wu D,Liang JP,Cao BY,Gu Y,Su C,Liang XJ,Liu M,Wang R,Li FT

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Both cortical and cortical-subcortical (cortex-involved) lesions are typically associated with embolic stroke, of which atrial fibrillation (AF) is the common cause. The aim of this study was to find out the associations between cortex-involved stroke, vascular risk factors, and the subtypes (discovery time ...

journal_title：Chinese medical journal

authors： Li SY,Yang XM,Zhao XQ,Liu LP,Wang YL,Jiang Y,Wang YJ

更新日期：2019-09-05 00:00:00

abstract：BACKGROUND:Homoharringtonine (HHT) is a cephalotaxine ester derived from an evergreen tree found wildely throughout southern China, which has antileukemic activities against a variety of acute myeloid leukemic cells. For the sake of illustrating the mechanisms of HHT in the treatment of leukemia, we assessed the effect...

journal_title：Chinese medical journal

authors： Mai WY,Lin MF

更新日期：2005-03-20 00:00:00

abstract：BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease. STK11/LKB1 gene germline mutations have been identified as responsible for PJS. In our study, we investigated the molecular basis of PJS and evaluated correlation between the STK11 mutations and the Chinese population. METHODS:We col...

journal_title：Chinese medical journal

authors： Zuo YG,Xu KJ,Su B,Ho MG,Liu YH

更新日期：2007-07-05 00:00:00

abstract：BACKGROUND:Myocardial bridging with systolic compression of the left anterior descending coronary artery (LAD) may be associated with myocardial ischaemia. The clinical outcome in patients with surgical treatment for symptomatic myocardial bridging remains undetermined. This study assessed the middle- and long-term res...

journal_title：Chinese medical journal

authors： Huang XH,Wang SY,Xu JP,Song YH,Sun HS,Tang Y,Dong C,Yang YJ,Hu SS

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:Adenomyosis is a gynecological disorder with symptoms most presenting as dysmenorrhea and heavy menstrual bleeding. However, the presence of lower urinary tract symptoms (LUTS) among women with adenomyosis remains unclear. This study was designed to determine the prevalence of LUTS and factors related to the...

journal_title：Chinese medical journal

authors： Li T,Xu XX,Dai Y,Zhang JJ,Lang JH,Leng JH

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Sacroiliac (SI) screw fixation is a demanding technique, with a high rate of screw malposition due to the complex pelvic anatomy. TiRobot™ is an orthopedic surgery robot which can be used for SI screw fixation. This study aimed to evaluate the accuracy of robot-assisted placement of SI screws compared with a...

journal_title：Chinese medical journal

authors： Wang JQ,Wang Y,Feng Y,Han W,Su YG,Liu WY,Zhang WJ,Wu XB,Wang MY,Fan YB

更新日期：2017-11-05 00:00:00

abstract：OBJECTIVE:Secreted modular calcium-binding proteins (SMOCs) are extracellular glycoproteins of the secreted protein, acidic, and rich in cysteine-related modular calcium-binding protein family and include two isoforms, SMOC1 and SMOC2, in humans. Functionally, SMOCs bind to calcium for various cell functions. In this r...

journal_title：Chinese medical journal

authors： Gao Q,Mok HP,Zhuang J

更新日期：2019-10-20 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that ephrin-A2 and -A3 negatively regulate the growth of neural progenitor cells in the central nervous system. Adult mice deficient in ephrin-A2 and -A3 (A2(-/-)A3(-/-)) displayed active ongoing neurogenesis throughout the brain, and mice deficient in ephrin-A3 alone sho...

journal_title：Chinese medical journal

authors： Zhu R,Cho KS,Chen DF,Yang L

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Hypertension is an important risk factor of cardiovascular disease and increases mortality in the elderly. However, the available medical evidences are both inconsistent and insufficient regarding establishing credible and useful blood pressure (BP) targets in the hypertensive elderly. This review summarizes ...

journal_title：Chinese medical journal

authors： Liu P,Zheng JG

更新日期：2017-08-20 00:00:00

abstract：BACKGROUND:Few clinical studies or randomized clinical trial results have reported the impact of fast track surgery on postoperative insulin sensitivity. This study aimed to investigate the effects of fast track surgery on postoperative insulin sensitivity in patients undergoing elective open colorectal resection. MET...

journal_title：Chinese medical journal

authors： Yang DJ,Zhang S,He WL,Chen HY,Cai SR,Chen CQ,Song XM,Cui J,Ma JP,Zhang CH,He YL

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Human urotensin II (UII) is the most potent mammalian vasoconstrictor identified so far. Our previous study showed that UII is a potent mitogen of airway smooth muscle cells (ASMC) inducing ASMC proliferation in a dose-dependent manner. The signal transduction pathway of UII mitogenic effect remains to be cl...

journal_title：Chinese medical journal

authors： Chen YH,Zhao MW,Yao WZ,Pang YZ,Tang CS

更新日期：2004-01-01 00:00:00

abstract：Background:The increasing frequency of explosive injuries has increased interest in blast-induced traumatic brain injury (bTBI). Various shock tube models have been used to study bTBI. Mild-to-moderate explosions are often overlooked because of the slow onset or mildness of the symptoms. However, heavy gas cylinders an...

journal_title：Chinese medical journal

authors： Zhou Y,Wen LL,Wang HD,Zhou XM,Fang J,Zhu JH,Ding K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:The chronic obstructive pulmonary disease assessment test (CAT) is an easy to use health-related quality of life questionnaire, the modified Medical Research Council (mMRC) dyspnea scale is a classic dyspnea scale which is widely used, while the correlation between them is still not clear. This study investi...

journal_title：Chinese medical journal

authors： Zhou QT,Mei JJ,He B,Huang SG,Shi Y,Wen FQ,Zhao MW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Monolayer cell culture models are the traditional culture models used for in vitro research of pancreatic carcinoma chemosensitivity. However, these models neglect the interactions between tumor cells and the impact of the tumor microenvironment. Such tumor cell monolayers poorly mimic the solid tumor microe...

journal_title：Chinese medical journal

authors： Liao Q,Hu Y,Zhao YP,Zhou T,Zhang Q

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Oxygen inhalation therapy is essential for the treatment of patients with chronic mountain sickness (CMS), but the efficacy of oxygen inhalation for populations at high risk of CMS remains unknown. This research investigated whether oxygen inhalation therapy benefits populations at high risk of CMS. METHODS...

journal_title：Chinese medical journal

authors： Feng B,Xu WH,Gao YQ,Liu FY,Li P,Zheng SJ,Gai LY,Zhang G

更新日期：2016-06-05 00:00:00

abstract：OBJECTIVES:To formulate an equation for fine mapping of disease loci under complex conditions and determine the marker-disease distance in a specific case using this equation. METHODS:Lewontin's linkage disequilibrium (LD) measure D' was used to formulate an equation for mapping disease genes in the presence of phenoc...

journal_title：Chinese medical journal

authors： Gong G,Haynatzki G,Deng HW,Recker RR,Mordeson J,Cheng SC,Fong N

更新日期：2002-08-01 00:00:00