Abstract:
OBJECTIVE:5-Fluorouracil (5-FU)-based combination therapies are standard treatments for gastrointestinal cancer, where the modulation of autophagy is becoming increasingly important in offering effective treatment for patients in clinical practice. This review focuses on the role of autophagy in 5-FU-induced tumor suppression and cancer therapy in the digestive system. DATA SOURCES:All articles published in English from 1996 to date those assess the synergistic effect of autophagy and 5-FU in gastrointestinal cancer therapy were identified through a systematic online search by use of PubMed. The search terms were "autophagy" and "5-FU" and ("colorectal cancer" or "hepatocellular carcinoma" or "pancreatic adenocarcinoma" or "esophageal cancer" or "gallbladder carcinoma" or "gastric cancer"). STUDY SELECTION:Critical reviews on relevant aspects and original articles reporting in vitro and/or in vivo results regarding the efficiency of autophagy and 5-FU in gastrointestinal cancer therapy were reviewed, analyzed, and summarized. The exclusion criteria for the articles were as follows: (1) new materials (e.g., nanomaterial)-induced autophagy; (2) clinical and experimental studies on diagnostic and/or prognostic biomarkers in digestive system cancers; and (3) immunogenic cell death for anticancer chemotherapy. RESULTS:Most cell and animal experiments showed inhibition of autophagy by either pharmacological approaches or via genetic silencing of autophagy regulatory gene, resulting in a promotion of 5-FU-induced cancer cells death. Meanwhile, autophagy also plays a pro-death role and may mediate cell death in certain cancer cells where apoptosis is defective or difficult to induce. The dual role of autophagy complicates the use of autophagy inhibitor or inducer in cancer chemotherapy and generates inconsistency to an extent in clinic trials. CONCLUSION:Autophagy might be a therapeutic target that sensitizes the 5-FU treatment in gastrointestinal cancer.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Tang JC,Feng YL,Liang X,Cai XJdoi
10.4103/0366-6999.176069subject
Has Abstractpub_date
2016-02-20 00:00:00pages
456-63issue
4eissn
0366-6999issn
2542-5641pii
ChinMedJ_2016_129_4_456_176069journal_volume
129pub_type
杂志文章,评审abstract:BACKGROUND:Retroperitoneal sarcoma is a rare disease with poor prognosis. The aim of this study was to investigate the prognostic factors of the disease. METHODS:Between January 1988 and December 2003, 132 patients with retroperitoneal sarcoma were surgically treated in our hospital, 79 of them were followed up for 1 ...
journal_title:Chinese medical journal
pub_type: 杂志文章
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abstract:BACKGROUND:Intravertebral and general anesthesia (GA) are two main anesthesia approaches but both have defects. This study was aimed to evaluate the effect of subarachnoid anesthesia combined with propofol target-controlled infusion (TCI) on blood loss and transfusion for total hip arthroplasty (THA) in elderly patient...
journal_title:Chinese medical journal
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
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abstract:OBJECTIVE:To explore the pathogenesis of glucose metabolic disorder and insulin resistance in critically ill children under severe stress. METHODS:To test glucose, lactate, glucagon, insulin, c-peptide, cortisol levels in 50 critically ill children. While we measured 125I-insulin binding to erythrocytes of 13 critical...
journal_title:Chinese medical journal
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
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pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
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doi:10.4103/0366-6999.192772
更新日期:2016-11-05 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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abstract:: ...
journal_title:Chinese medical journal
pub_type: 社论
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更新日期:2018-11-20 00:00:00
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journal_title:Chinese medical journal
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