CCR1 and CCR5 expression on inflammatory cells is related to cigarette smoking and chronic obstructive pulmonary disease severity.

Abstract:

BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive disease associated with a cellular inflammatory response mostly concerned with cigarette smoking. Chemokine receptors CCR1/5 play an important role in the inflammatory cells recruitment in the lung of COPD patients. The aim of this study was to determine the impact of cigarette smoking on the expression of CCR1/5 on inflammatory cells in induced sputum, and the relationship between the receptors expression and COPD severity. METHODS:Differential cells in induced sputum were counted and the optical densities of CCR1 and CCR5 on inflammatory cells in induced sputum from COPD patients (n = 29), healthy smokers (n = 11), and nonsmokers (n = 6) were measured using immunocytochemistry. Concentrations of CCL3, the ligand of CCR1/5, in supernatant of induced sputum were detected by enzyme-linked immunosorbent assay. RESULTS:The expressions of CCR1 and CCR5 on inflammatory cells in healthy smokers were significantly higher than those in nonsmokers, and the expression of CCR1 in patients with COPD was significantly increased when compared with nonsmokers but not healthy smokers. The expressions of CCR1 and CCR5 on inflammatory cells in severe and very severe COPD patients were higher compared with mild and moderate COPD patients. CCL3 level was positively correlated with the total cell counts in induced sputum and smoking history, and negatively correlated with percentage of predicted FEV(1). CONCLUSIONS:Cigarette smoking could increase the expression of CCR1 on the inflammatory cells. Both CCR1 and CCR5 expressions on the inflammatory cells in induced sputum could be associated with COPD severity.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Wang F,He B

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

4277-82

issue

23

eissn

0366-6999

issn

2542-5641

journal_volume

125

pub_type

杂志文章
  • Preliminary observation on human saliva alpha-fetoprotein in patients with hepatocellular carcinoma.

    abstract::The saliva samples from 13 patients with hepatocellular carcinoma and a control group of 21 random healthy adults were measured for alpha-fetoprotein (AFP), using a highly sensitive sandwich enzyme immunoassay specific for human AFP. In patients with hepatocellular carcinoma, significantly higher levels of saliva AFP ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: You XY,Jiang J,Yin FZ

    更新日期:1993-03-01 00:00:00

  • Heliox as a driving gas to atomize inhaled drugs on acute exacerbation of chronic obstructive pulmonary disease: a prospective clinical study.

    abstract:BACKGROUND:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common condition, which affects not only the quality of life of patients but also their prognosis. The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the gluco...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xiao Y,Su L,Han B,Zhang X,Xie L

    更新日期:2014-01-01 00:00:00

  • Comparison of drug eluting stent implantation with coronary artery bypass surgery in the treatment of patients with chronic total occlusion and multiple vessel disease.

    abstract:BACKGROUND:In patients with chronic total occlusion (CTO) and multivessel coronary artery disease, the comparison of surgical and the percutaneous revascularization strategies has rarely been conducted. The aim of this study was to compare long term clinical outcomes of drug eluting stent (DES) implantation with corona...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu W,Ma CS,Kang JP,Du X,Chen F,Zhou YJ,Lü SZ,Huang FJ,Gu CX,Zhu XL

    更新日期:2011-04-01 00:00:00

  • Inhibition of periostin gene expression via RNA interference suppressed the proliferation, apoptosis and invasion in U2OS cells.

    abstract:BACKGROUND:Periostin originally designated osteoblast-specific factor 2 (OSF-2) is frequently found to be highly expressed in various types of human cancer cell lines in vitro and human cancer tissues in vivo. We proposed that periostin was a key factor during the process of proliferation and invasion in cancer cells. ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu C,Huang SJ,Qin ZL

    更新日期:2010-12-01 00:00:00

  • Magnetic resonance imaging of the extraocular muscles and corresponding cranial nerves in patients with special forms of strabismus.

    abstract:BACKGROUND:With the technical advances, magnetic resonance imaging (MRI) is now sensitive enough to detect subtle structural abnormalities of ocular motor nerves arising from the brainstem and orbits of living subjects. This study was designed to delineate the MRI characteristics in patients with special forms of strab...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Jiao YH,Zhao KX,Wang ZC,Qian XH,Wu X,Man FY,Lu W,She HC

    更新日期:2009-12-20 00:00:00

  • The utilization status of aspirin for the secondary prevention of ischemic stroke.

    abstract:BACKGROUND:The present study was aimed to investigate the usage of aspirin for the secondary prevention of ischemic stroke, evaluate the correlated factors, and analyze the reasons for not taking and irregularly taking aspirin. METHODS:The patients in this group were all stroke survivors who have formerly been diagnos...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ke XJ,Yu YF,Guo ZL,Xu K,Hai H,Zhang AH,Jiang H,Peng H

    更新日期:2009-01-20 00:00:00

  • Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis.

    abstract:BACKGROUND:Recent studies have suggested that p38 mitogen-activated protein kinases (MAPK) signalling pathway plays an important role in hepatic fibrosis. This study explored the antifibrotic effect of oxymatrine on tetrachloromethane induced liver fibrosis in rats and its modulation on the p38 MAPK signalling pathway....

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Deng ZY,Li J,Jin Y,Chen XL,Lü XW

    更新日期:2009-06-20 00:00:00

  • Apolipoprotein (a) phenotypes in cardio-cerebrovascular diseases.

    abstract::Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhuang YY,Li JJ,Wang JJ

    更新日期:1994-02-01 00:00:00

  • Diagnostic value of magnetocardiography in patients with coronary heart disease and in-stent restenosis.

    abstract:BACKGROUND:In-stent restenosis (ISR) has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted to explore the potential of magnetocardiography (MCG) in diagnosis of in-stent restenosis....

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Quan WW,Lu GP,Qi WH,Li YM,Shen Y,Yuan R

    更新日期:2008-01-05 00:00:00

  • Effect of an Ilex asprella root decoction on the related genes of lipid metabolism from chronic stress and hyperlipidemic fatty liver in rats.

    abstract:BACKGROUND:The gradually increasing changes in a human hyperlipidemic diet along with chronic stress might play an important role in the increased numbers of fatty liver. This study investigated the effects of Ilex asprella root decoction on related genes of lipid metabolism in chronic stress in hyperlipidemic fatty li...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Hu XY,Shu XC,Guo Y,Ma Y

    更新日期:2012-10-01 00:00:00

  • Living near a Major Road in Beijing: Association with Lower Lung Function, Airway Acidification, and Chronic Cough.

    abstract:BACKGROUND:The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. METHODS:We enrolled 1003 residents aged 57.96 ± 8.99 years livi...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.189923

    authors: Hu ZW,Zhao YN,Cheng Y,Guo CY,Wang X,Li N,Liu JQ,Kang H,Xia GG,Hu P,Zhang PJ,Ma J,Liu Y,Zhang C,Su L,Wang GF

    更新日期:2016-09-20 00:00:00

  • Dynesys dynamic stabilization system for the lumbar degenerative disease: a preliminary report from China.

    abstract:BACKGROUND:Dynesys dynamic stabilization system was first implanted in patients in 1994, and introduced to China in 2007. Therefore, it was a new technique for Chinese orthopedics and hence necessary to collect clinical data about Dynesys in China. The objective of this study was to report the preliminary results of Dy...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li HP,Li F,Guan K,Zhao GM,Shan JL,Sun TS

    更新日期:2013-11-01 00:00:00

  • Thirty-day Postoperative Complications following Primary Total Knee Arthroplasty: A Retrospective Study of Incidence and Risk Factors at a Single Center in China.

    abstract:BACKGROUND:Total knee arthroplasty (TKA) may be associated with serious complications that adversely affect outcomes and increase the likelihood of disability. However, few studies with sufficient sample size have reported postoperative complications following TKA among Chinese patients. This study aimed to evaluate co...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.213071

    authors: Feng B,Lin J,Jin J,Qian WW,Wang W,Weng XS

    更新日期:2017-11-05 00:00:00

  • Effect of mitochondrial KATP channel on voltage-gated K+ channel in 24 hour-hypoxic human pulmonary artery smooth muscle cells.

    abstract:BACKGROUND:Hypoxic pulmonary hypertension (HPH) is initiated by inhibition of O2-sensitive, voltage-gated (Kv) channels in pulmonary arterial smooth muscle cells (PASMCs). The mechanism of hypoxic pulmonary hypertension has not yet been fully elucidated. The mitochondrial ATP-sensitive K+ channel (MitoKATP) is extremel...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang T,Zhang ZX,Xu YJ

    更新日期:2005-01-05 00:00:00

  • Ability of lower teardrop edge to restore anatomical hip center height in total hip arthroplasty.

    abstract:BACKGROUND:The acetabular teardrop is often used to guide acetabular component placement in total hip arthroplasty (THA). Placing the lower acetabular component aspect at the same level as the lower teardrop edge was assumed to restore the hip center of rotation. Here we radiographically analyzed the relationship betwe...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lu Y,Cheng L,Guo W,Yu Q,Gao F,Zhang Q,Liu Z,Sun W,Shi Z

    更新日期:2014-01-01 00:00:00

  • Arthroscopic reduction and fixation for isolated greater tuberosity fractures.

    abstract:BACKGROUND:Traditionally, displaced greater tuberosity fractures are treated with open reduction and internal fixation. Arthroscopic treatment and outcome of greater tuberosity fractures is far from comprehensive. The objective of the current study was to assess the surgical procedure and outcome of an arthroscopic met...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang YP,Zhao JZ,Huangfu XQ,Liu WX,Jiang Y,Zhou XH,He YH

    更新日期:2012-04-01 00:00:00

  • Genotyping and preparation of the recombinant nucleocapsid protein antigen of hantavirus.

    abstract:OBJECTIVE:To identify new recombinant antigens with potential for diagnosis of hemorrhagic fever with renal syndrome (HFRS) and establish reverse transcription-polymerase chain reaction-restriction fragments length polymorphism (RT-PCR-RFLP) for genotyping of hantavirus. METHODS:One group of primers was used to clone ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tang J,Cao M,Tang T,Wang C,Wei C,Lei W

    更新日期:2001-10-01 00:00:00

  • A report on selective radiofrequency ablation of dual atrioventricular node pathways in 34 cases.

    abstract::Selective ablation of slow pathway by radiofrequency (RF) current in 34 patients with atrioventricular (AV) node pathways and tachycardia was performed with two methods in our section; posterior approach was used in the first 12 patients, the slow pathways were ablated successfully. Inferior approach was performed in ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Hu DY,Ding YS,Ma CS,Li YG,Li YF,Wang LX,Wang LH

    更新日期:1994-08-01 00:00:00

  • Further characterization of Chinese Leishmania isolates by isoenzyme electrophoresis.

    abstract::Ten Chinese Leishmania isolates from different endemic areas and hosts are characterized by isoenzyme electrophoresis for 9 enzymes. Seven were isolated from visceral leishmaniasis patients, one from an infected dog, one from a sandfly and one from a naturally infected racoon dog. Eight of the 10 isolates were indisti...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu ZB,Liu ZT,Long JY,Chai JJ,Chen WK

    更新日期:1989-09-01 00:00:00

  • Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice.

    abstract:BACKGROUND:Paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridinium), a widely used herbicide that is structurally similar to the known dopaminergic neurotoxicant MPTP (1-methyl-1, 2, 3, 6-tetrahydropyridine), has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). Aging is an accepte...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li X,Yin J,Cheng CM,Sun JL,Li Z,Wu YL

    更新日期:2005-08-20 00:00:00

  • Duck hepatitis B virus model for screening of antiviral agents from medicinal herbs.

    abstract::The effects of the extracts of 20 Chinese medicinal herbs and an antiviral drug foscarnet on duck hepatitis B virus (DHBV) endogenous DNA polymerase (DNAp) activity were compared. The extracts of P. urinaria showed a dose-dependent inhibition on DHBV DNAp. And those of other herbs showed little inhibition effect. Prim...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Mi Z,Chen H,Zhang X,Shao X,Li Z,Wu X

    更新日期:1995-09-01 00:00:00

  • Dermoscopy in China: current status and future prospective.

    abstract:OBJECTIVE:Dermoscopy is a useful technique for improving the diagnostic accuracy of various types of skin disorders. In China, dermoscopy has been widely accepted, and domestic researchers have made tremendous progress in the field of dermoscopy. The main purpose of this review is to summarize the current status of der...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000396

    authors: Shen X,Yu RX,Shen CB,Li CX,Jing Y,Zheng YJ,Wang ZY,Xue K,Xu F,Yu JB,Meng RS,Cui Y

    更新日期:2019-09-05 00:00:00

  • Side effects and tolerability of post-exposure prophylaxis with zidovudine, lamivudine, and lopinavir/ritonavir: a comparative study with HIV/AIDS patients.

    abstract:BACKGROUND:In the era of highly active antiretroviral therapy (HAART), the use of antiretrovirals as post-exposure prophylaxis (PEP) was the most important strategy for preventing occupational exposure to blood or fluids containing human immunodeficiency virus (HIV). The objective of this study was to retrospectively e...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Cai J,Xiao J,Zhang Q

    更新日期:2014-01-01 00:00:00

  • Lipid signal in evaluation of intracranial meningiomas.

    abstract:BACKGROUND:Using magnetic resonance imaging, diagnosis of malignant meningioma from benign meningioma with atypical features is uncertain. We evaluated the value of lipid signal in differentiating intracranial meningiomas. METHODS:1H-magnetic resonance spectroscopy (MRS) using a point resolved spectroscopy (TR/TE 1000...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Qi ZG,Li YX,Wang Y,Geng DY,Li KC,Shen TZ,Chen XR

    更新日期:2008-12-05 00:00:00

  • Establishing a Customized Guide Plate for Osteotomy in Total Knee Arthroplasty Using Lower-extremity X-ray and Knee Computed Tomography Images.

    abstract:BACKGROUND:The conventional method cannot guarantee the precise osteotomies required for a perfect realignment and a better prognosis after total knee arthroplasty (TKA). This study investigated a customized guide plate for osteotomy placement in TKAs with the aid of the statistical shape model technique using weight-b...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.176082

    authors: Zhang J,Tian XB,Sun L,Hu RY,Tian JL,Han W,Zhao JM

    更新日期:2016-02-20 00:00:00

  • Over-expression of c-fos mRNA in the hippocampal neurons in Alzheimer's disease.

    abstract:OBJECTIVE:To analyze the relationship between the proto-oncogene c-fos change and neuronal degeneration in the hippocampus of the patients with Alzheimer's disease. METHODS:The post mortem human hippocampal tissues were divided into three groups, namely, the aged, the young and Alzheimer's disease (AD) groups. Each gr...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lu W,Mi R,Tang H,Liu S,Fan M,Wang L

    更新日期:1998-01-01 00:00:00

  • Early-phase changes of P-wave characteristics after circumferential pulmonary vein isolation.

    abstract:BACKGROUND:Circumferential pulmonary vein isolation (CPVI), as the basal ablation strategy for treating atrial fibrillation (AF), not only isolates the connection between the left atrium (LA) and the pulmonary veins (PVs), but also induces extensive atrial endocardia damage. This could have an effect on the sinus pulse...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhao L,Jiang WF,Zhou L,Liu X

    更新日期:2013-07-01 00:00:00

  • Endovascular treatment of cerebral arteriovenous malformations with Onyx embolization.

    abstract:BACKGROUND:In the past 5 years, new treatment materials and techniques offering a different concept in endovascular treatment have been described for cerebral arteriovenous malformations (CAVMs). The aim of this study was to assess the endovascular treatment of CAVMs by using a liquid embolic material, Onyx (Micro Ther...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: He HW,Jiang CH,Liu HB,Li YX,Zhang JB,Wu ZX

    更新日期:2005-12-20 00:00:00

  • Effect of artificial colloids on blood coagulation during shock stage of severe burn injury.

    abstract:BACKGROUND:There are controversies about the use of artificial colloids. This research was aimed to determine the effect of various artificial colloids on blood coagulation in the shock stage of severe burn injury. METHODS:Totally, 18 female Ba-Ma mini-pigs were subjected to a 40% total body surface third-degree flame...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhou JJ,Xing N,Chen J,Shi JW,Su GL

    更新日期:2013-01-01 00:00:00

  • Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus.

    abstract:BACKGROUND:Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases. METHODS:Collecting clinical data of three cases of human infection with a novel reas...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang W,Wan J,Qian K,Liu X,Xiao Z,Sun J,Zeng Z,Wang Q,Zhang J,Jiang G,Nie C,Jiang R,Ding C,Li R,Horby P,Gao Z

    更新日期:2014-01-01 00:00:00