Evaluation of efficacy and safety of sunitinib regimen in 22 patients with metastatic renal cell carcinoma: at least 12-month follow-up.

Abstract:

BACKGROUND:Sunitinib has been proved an effective new option for treatment of metastatic renal cell carcinoma (mRCC). Analysis of clinical data of 22 patients, who were exposed to sunitinib for at least 1 year, was conducted to evaluate the long-term efficacy and safety of sunitinib for the treatment of mRCC. METHODS:A total of 54 patients with mRCC were treated with sunitinib malate, 50 mg/d orally, on a 4-weeks-on and 2-weeks-off dosing schedule in Peking University First Hospital. Treatment continued until disease progression, unacceptable adverse events (AEs), or death. Among them, 22 patients continued treatment for at least 1 year. The clinical data of these 22 patients were prospectively collected for analysis. AEs were assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3.0. Tumor response was evaluated in accordance with the Response Evaluation Criteria in Solid Tumors. RESULTS:Median progression-free survival was 19.5 months until last follow-up. The best efficacy results achieved were complete response, partial response, and stable disease for 2, 9, and 11 patients, respectively. Objective response rate was 50%. The most common AEs were hand-foot syndrome (95%) and hypertension (91%). Other common AEs were thyroid-stimulating hormone elevation (82%), platelet decrease (77%), and loss of appetite (77%). Only one patient withdrew from treatment for cardiac infarction. Another nine patients experienced dose modifications or short-term suspensions. CONCLUSION:Long-term exposure to sunitinib malate showed encouraging efficacy in the treatment of mRCC. At the same time, the tolerability was good.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Zhang CJ,Zhao PJ,Li XS,Zhao J,Huang LH,Song Y,Gong K,Shen C,Yu W,Song G,Zhao Z,Zhang Z,Zhang Q,He ZS,Jin J,Zhou LQ

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2826-9

issue

15

eissn

0366-6999

issn

2542-5641

journal_volume

126

pub_type

杂志文章
  • Incubation and application of transgenic green fluorescent nude mice in visualization studies on glioma tissue remodeling.

    abstract:BACKGROUND:The primary reasons for local recurrence and therapeutic failure in the treatment of malignant gliomas are the invasion and interactions of tumor cells with surrounding normal brain cells. However, these tumor cells are hard to be visualized directly in histopathological preparations, or in experimental glio...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Dong J,Dai XL,Lu ZH,Fei XF,Chen H,Zhang QB,Zhao YD,Wang ZM,Wang AD,Lan Q,Huang Q

    更新日期:2012-12-01 00:00:00

  • Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.

    abstract:BACKGROUND:Ovarian serous adenocarcinoma can be divided into low- and high-grade tumors, which exhibit substantial differences in pathogenesis, clinicopathology, and prognosis. This study aimed to investigate the differences in the PH domain leucine-rich repeat protein phosphatase (PHLPP), forkhead homeobox type O 3a (...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.198932

    authors: Zhang J,Wang JC,Li YH,Wang RX,Fan XM

    更新日期:2017-02-05 00:00:00

  • Association between Maternal Weight Indicators and Iron Deficiency Anemia during Pregnancy: A Cohort Study.

    abstract:Background:The effect of maternal weights on the risk of iron deficiency anemia (IDA) during pregnancy remains unclear. The study aimed to investigate the association between maternal weight indicators and IDA during pregnancy. Methods:We conducted a cohort study to examine the association between maternal weight indi...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.244109

    authors: Tan J,Qi YN,He GL,Yang HM,Zhang GT,Zou K,Luo W,Sun X,Liu XH

    更新日期:2018-11-05 00:00:00

  • Comparison of tirofiban combined with dalteparin or unfractionated heparin in primary percutaneous coronary intervention of acute ST-segment elevation myocardial infarction patients.

    abstract:BACKGROUND:Primary percutaneous coronary intervention (PCI) is the best treatment of choice for acute ST segment elevation myocardial infarction (STEMI). This study aimed to determine the clinical outcomes of tirofiban combined with the low molecular weight heparin (LMWH), dalteparin, in primary PCI patients with acute...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Li WM,Yang XC,Wang LF,Ge YG,Wang HS,Xu L,Ni ZH,Zhang DP

    更新日期:2011-10-01 00:00:00

  • Effect of homocysteine on plaque formation and oxidative stress in patients with acute coronary syndromes.

    abstract:BACKGROUND:Cardiovascular diseases, especially coronary artery disease (CAD), are major causes of death in industrialized countries. Elevated concentrations of plasma homocysteine (Hcy) have been associated with an increased risk of CAD. Increased plasma levels of chemokine, characterized by their ability to induce mig...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang G,Mao JM,Wang X,Zhang FC

    更新日期:2004-11-01 00:00:00

  • Impact of the origin of sinus node artery on recurrence after pulmonary vein isolation in patients with paroxysmal atrial fibrillation.

    abstract:BACKGROUND:Major atrial coronary arteries, including the sinus node artery (SNA), were commonly found in the areas involved in atrial fibrillation (AF) ablation and could cause difficulties in achieving linear block at the left atrial (LA) roof. The SNA is a major atrial coronary artery of the atrial coronary circulati...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang ZJ,Chen K,Tang RB,Sang CH,Lao EP,Yan Q,He XN,DU X,Long DY,Yu RH,Dong JZ,Ma CS

    更新日期:2013-01-01 00:00:00

  • Annular pancreas. Etiology, classification and diagnostic imaging.

    abstract::A rare type of annular pancreas, in which the tail of the annular duct is fused with the dorsal pancreatic duct to form the main duct, and its diagnostic imagings of endoscopic retrograde cholangiopancreatography, hypotonic duodenography, computed tomography and ultrasound are described. Annular pancreas is an anomaly...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lin SZ

    更新日期:1989-05-01 00:00:00

  • Circular RNAs: from biogenesis and function to diseases.

    abstract:OBJECTIVE:Evidence suggests that various diseases may contribute to the circular RNAs (circRNAs) expression disorder. This review was aimed at looking for appropriate biomarkers for the treatment of diseases. DATA SOURCES:The comprehensive search used online literature databases including PubMed of National Center for...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000465

    authors: Li D,Yang Y,Li ZQ,Li LC,Zhu XH

    更新日期:2019-10-20 00:00:00

  • Effects of different levels of end-expiratory positive pressure on lung recruitment and protection in patients with acute respiratory distress syndrome.

    abstract:BACKGROUND:It is still controversial as to the implementation of higher positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS). This study was conducted to compare the lower and higher PEEP in patients with ARDS ventilated with low tidal volume, to investigate the relationsh...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Guo FM,Ding JJ,Su X,Xu HY,Shi Y

    更新日期:2008-11-20 00:00:00

  • Association of interleukin-6 promoter polymorphism with knee osteoarthritis: a meta-analysis.

    abstract:BACKGROUND:Osteoarthritis (OA) is the most common form of human polyarthritis. Many genetic factors have been implicated in OA. It was reported that a polymorphism in the gene of interleukin-6 (IL-6) was associated with OA of knee. The aim of this study was to determine whether functional IL-6 promoter -174G/C (rs18007...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,meta分析

    doi:

    authors: Ai Z,Ning X,Shou T,Tang W,Luo Y,Zhang J

    更新日期:2014-01-01 00:00:00

  • Clinical Analysis of Postpartum Hemorrhage Requiring Massive Transfusions at a Tertiary Center.

    abstract:BACKGROUND:The reports on massive transfusions (MTs) in obstetrics have recently been an increasing trend. We aimed to define the clinical features, risk factors, main causes, and outcomes of MTs due to severe postpartum hemorrhage (PPH) and the frequency trends over the past 10 years. METHODS:We retrospectively analy...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.200545

    authors: Hu J,Yu ZP,Wang P,Shi CY,Yang HX

    更新日期:2017-03-05 00:00:00

  • A preliminary study of imaging paclitaxel-induced tumor apoptosis with (99)Tc(m)-His10-Annexin V.

    abstract:BACKGROUND:In tumors the process of apoptosis occurs over an interval of time after chemotherapy. It is important to determine the best time for detecting apoptosis by in vivo imaging. In this study, we evaluated the dynamics and feasibility of imaging non-small cell lung cancer (NSCLC) apoptosis induced by paclitaxel ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zheng YM,Wang F,Fang W,Hua ZC,Wang ZZ,Meng QL,Yan J

    更新日期:2013-01-01 00:00:00

  • Hypoxia-inducible factor-1alpha induces the epithelial-mesenchymal transition of human prostatecancer cells.

    abstract:BACKGROUND:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcriptional factor that could improve the stimulation of angiogenesis and the metabolic adaptation of tumor cells to hypoxia. A recent study showed that HIF-1alpha could induce colon cancer cells epithelial-mesenchymal transition (EMT). However, no eviden...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Luo Y,He DL,Ning L,Shen SL,Li L,Li X

    更新日期:2006-05-05 00:00:00

  • Blood Pressure Targets in the Hypertensive Elderly.

    abstract:OBJECTIVE:Hypertension is an important risk factor of cardiovascular disease and increases mortality in the elderly. However, the available medical evidences are both inconsistent and insufficient regarding establishing credible and useful blood pressure (BP) targets in the hypertensive elderly. This review summarizes ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.4103/0366-6999.211885

    authors: Liu P,Zheng JG

    更新日期:2017-08-20 00:00:00

  • Antileukemic effect of low-dose harringtonine.

    abstract::The effect of harringtonine (HA) in various concentrations on HL-60 was evaluated. 0.10 microgram/ml HA showed a strong cell killing effect, and 0.025 microgram/ml HA a weak differentiation induction accompanied by cell growth retardation. Differentiation induction did not occur in 5 other human leukemic cell lines. W...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen SS,Wang P,Fu JY,Chen LL,Zhao FS,Shan FX

    更新日期:1989-06-01 00:00:00

  • Stent-grafting for unfavorable abdominal aortic aneurysm: a practical challenge.

    abstract:BACKGROUND:The endovascular treatment of abdominal aortic aneurysm (AAA) has improved greatly in the last 15 years. The present study aimed to evaluate the endografting experience for the treatment of unfavorable abdominal aortic aneurysm (uAAA). METHODS:During December 2001 and December 2007, 41 patients with uAAA we...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Hu ZJ,Chang GQ,Li XX,Huang XL,Yin HH,Wang SM

    更新日期:2009-04-05 00:00:00

  • The basic clinical diagnostic framework synergized.

    abstract:OBJECTIVE:To develop a diagnostic framework that would help defining clinical problems by the expanded understanding with traditional Chinese medicine (C Med) and western medicine (W Med). METHODS:The basic attributes of diagnosis and the use of diagnostic techniques of W Med and C Med are reviewed. Some of the variou...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Yu EC

    更新日期:1998-05-01 00:00:00

  • Evidence of compromised circulation in the pathogenesis of optic nerve damage in chronic glaucomatous rabbit.

    abstract::The protective effect of improving the microcirculation on the retinal ganglion cells (RGC) and the ultrastructure of the optic nerve after intravenous (i.v.) use of Salviae miltiorrhiza (SMR) was studied in a chronic intraocular hypertension model in 36 rabbits. These rabbits were treated with topical 0.5% timolol, o...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu MD,Cai FY

    更新日期:1993-12-01 00:00:00

  • Cutaneous Rosai-Dorfman disease presenting as a granulomatous rosacea-like rashs.

    abstract::A case of cutaneous Rosai-Dorfman disease (CRDD) presenting as a granulomatous rosacea-like rashs was reported. A 45-year-old Chinese woman presented with a 1-month history of a widespread nonpruiginous papulonodular eruption. The rash had begun on her face and rapidly progressed to involve the neck and extremities. S...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Shi XY,Ma DL,Fang K

    更新日期:2011-03-01 00:00:00

  • Effects of estrogen and tibolone on bladder histology and estrogen receptors in rats.

    abstract:BACKGROUND:Estrogen deficiency causes atrophic changes within the urogenital tract, and is associated with urinary symptoms. The purpose of this study was to investigate the effects of estrogen and tibolone on bladder histology, and the changes of estrogen receptor alpha and beta (ERalpha and beta) protein expression i...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yang X,Li YZ,Mao Z,Gu P,Shang M

    更新日期:2009-02-20 00:00:00

  • Protective effect of recombinant human augmenter of liver regeneration on CCl4-induced hepatitis in mice.

    abstract:OBJECTIVE:To observe the anti-injury role of recombinant human augmenter of liver regeneration. METHODS:To establish liver injury models induced by CCl4 in vivo and in vitro, cell survival rates and LDH release rates served as observing index in experiments in vitro. Survival rates of liver failure animals, serum conc...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yang X,Wang A,Zhou P,Wang Q,Wei H,Wu Z,He F

    更新日期:1998-07-01 00:00:00

  • HIRA Gene is Lower Expressed in the Myocardium of Patients with Tetralogy of Fallot.

    abstract:BACKGROUND:The most typical cardiac abnormality is conotruncal defects (CTDs) in patients with 22q11 deletion syndrome (22q11DS). HIRA (histone cell cycle regulator) gene, as one of the candidate genes located at the critical region of 22q11DS, was reported as possibly relevant to CTD in animal models. This study aimed...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.191745

    authors: Ju ZR,Wang HJ,Ma XJ,Ma D,Huang GY

    更新日期:2016-10-20 00:00:00

  • Effect of artificial colloids on blood coagulation during shock stage of severe burn injury.

    abstract:BACKGROUND:There are controversies about the use of artificial colloids. This research was aimed to determine the effect of various artificial colloids on blood coagulation in the shock stage of severe burn injury. METHODS:Totally, 18 female Ba-Ma mini-pigs were subjected to a 40% total body surface third-degree flame...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhou JJ,Xing N,Chen J,Shi JW,Su GL

    更新日期:2013-01-01 00:00:00

  • Genomics-based Approach and Prognostic Stratification Significance of Gene Mutations in Intermediate-risk Acute Myeloid Leukemia.

    abstract:OBJECTIVE:Intermediate-risk acute myeloid leukemia (IR-AML), which accounts for a substantial number of AML cases, is highly heterogeneous. We systematically summarize the latest research progress on the significance of gene mutations for prognostic stratification of IR-AML. DATA SOURCES:We conducted a systemic search...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.4103/0366-6999.163400

    authors: Wang BH,Li YH,Yu L

    更新日期:2015-09-05 00:00:00

  • Effect of ginsenopolypeptide on the 3H-TdR integration of human blood lymphocyte.

    abstract::This paper reports the study of the effect of ginsenopolypeptide on 3H-TdR integration in normal human blood lymphocytes in vitro with micro-blood culture method of 3H-TdR integration. The results showed that the effect of ginsenopolypeptide on 3H-TdR integration in normal human peripheral blood lymphocytes which can ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wu S,Hua ZJ,Xiao YL,Wang Y,Zhang J,Zhang HY,Du WY

    更新日期:1991-05-01 00:00:00

  • Histological classification of schistosomal egg induced polyps of colon and their clinical significance. An analysis of 272 cases.

    abstract::272 cases of schistosomal egg induced polyps collected from mass-screening for colorectal carcinoma in Jiashan County were divided into 3 types: fibrous type (FT), mixed type (MT) and epithelial proliferative type (ET). The ET was characterized by crypt elongation, hypertrophy, variation in size, disorderly arrangemen...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yu XR,Chen PH,Xu JY,Xiao S,Shan ZJ,Zhu SJ

    更新日期:1991-01-01 00:00:00

  • Long-term follow-up study of 72 patients with transient ischemic attacks.

    abstract:OBJECTIVE:To observe the long-term follow-up of 72 patients with transient ischemic attack (TIA) and evaluate the clinical significance of neurovascular surgical indication. METHODS:Seventy-two patients with TIA collected from years 1959 to 1977 were followed up by means of face-to-face communication with the patients...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Gong T,Wang X

    更新日期:2001-12-01 00:00:00

  • Effects of advanced glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells.

    abstract:BACKGROUND:Advanced glycation end products (AGEs) play a critical role in the development of diabetic nephropathy. Reactive oxygen species (ROS) may play a critical role in AGEs induced growth factor expression. In this study, the effects of AGEs on transforming growth factor beta1 (TGF-beta1), connective tissue growth...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yan HD,Li XZ,Xie JM,Li M

    更新日期:2007-05-05 00:00:00

  • [Changes after dynamic observation of ultrastructural cerebral infarction in renovascular hypertensive rats].

    abstract:OBJECTIVE:To study the ultrastructural damages of brain tissues dynamically after middle cerebral artery obstruction (MCAO). METHODS:A middle cerebral artery obstruction (MCAO) model was reproduced in renal vascular hypertensive rats (RHR). Brain tissues in different locations were collected for eight times in row, fr...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Fang Y,Huang R,Su Z,Lin J,Li J

    更新日期:2000-06-01 00:00:00

  • Comparison of the anterior and posterior approach in treating four-level cervical spondylotic myelopathy.

    abstract:BACKGROUND:The optimal surgical approach for four-level cervical spondylotic myelopathy remains controversial. The purpose of this study was to compare clinical and radiological outcomes and complications between the anterior and posterior approaches for four-level cervical spondylotic myelopathy. METHODS:A total of 1...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000001146

    authors: Zhai JL,Guo SG,Nie L,Hu JH

    更新日期:2020-12-05 00:00:00