Abstract:
BACKGROUND:Telocytes (TCs) are a novel type of interstitial cells, which have been recently described in a large variety of cavitary and noncavitary organs. TCs have small cell bodies, and remarkably thin, long, and moniliform prolongations called telopodes (Tps). Until now, TCs have been found in various loose connective tissues surrounding the arterioles, venules, and capillaries, but as a histological cellular component, whether TCs exist in large arteries remains unexplored. METHODS:TCs were identified by transmission electron microscope in the aortic arch of male C57BL/6 mice. RESULTS:TCs in aortic arch had small cell bodies (length: 6.06-13.02 μm; width: 1.05-4.25 μm) with characteristics of specific long (7.74-39.05 μm), thin, and moniliform Tps; TCs distributed in the whole connective tissue layer of tunica adventitia: TCs in the innermost layer of tunica adventitia, located at the juncture between media and adventitia, with their long axes oriented parallel to the outer elastic membrane; and TCs in outer layers of tunica adventitia, were embedded among transverse and longitudinal oriented collagen fibers, forming a highly complex three-dimensional meshwork. Moreover, desmosomes were observed, serving as pathways connecting neighboring Tps. In addition, vesicles shed from the surface of TCs into the extracellular matrix, participating in some biological processes. CONCLUSIONS:TCs in aorta arch are a newly recognized complement distinct from other interstitial cells in large arteries, such as fibroblasts. And further biologically functional correlations need to be elucidated.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Zhang HQ,Lu SS,Xu T,Feng YL,Li H,Ge JBdoi
10.4103/0366-6999.150102subject
Has Abstractpub_date
2015-02-05 00:00:00pages
348-52issue
3eissn
0366-6999issn
2542-5641pii
ChinMedJ_2015_128_3_348_150102journal_volume
128pub_type
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