Overexpression and amplification of c-myc and c-Ha-ras oncogenes in pleomorphic salivary adenoma.

Abstract:

:Twenty-seven samples of pleomorphic salivary adenoma (PSA) were examined for expression and structure of c-myc, c-Ha-ras, c-erbB-2, c-sis oncogenes by RNA dot blot, DNA dot blot and Southern blot hybridization. Eighteen of 25 PSA showed 5.02 +/- 4.74 fold overexpression of c-myc oncogene, 6 of 19 PSA had 4.91 +/- 3.87 fold overexpression of c-Ha-ras oncogene. Two of 16 PSA were found to have overexpression of c-erbB-2 oncogene. In addition, 7 of 10 PSA and 1 of 9 PSA were detected to have c-myc and c-erbB-2 oncogene amplification respectively. However, no rearrangement, amplification or overexpression of c-sis gene was found. We also discussed various clinicopathological parameters of PSA, which however, had no significant correlation with expression of c-myc or c-Ha-ras oncogene. Our results indicate that activation of c-myc, c-Ha-ras and their combination may play an important role in the pathogenesis of PSA.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Xue H,Situ ZQ,Wang CJ,Wu JZ

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

22-5

issue

1

eissn

0366-6999

issn

2542-5641

journal_volume

106

pub_type

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