Effect of volume replacement with hydroxyethyl starch solution on splanchnic oxygenation in patients undergoing cytoreductive surgery for ovarian cancer.

Abstract:

OBJECTIVE:To investigate the effectiveness of using a medium molecular weight hydroxyethyl starch solution (HES) administered as a replacement for estimated blood loss (EBL) during cytoreductive surgery for ovarian cancer on splanchnic oxygenation. METHODS:Forty-two patients undergoing cytoreductive surgery for ovarian cancer were enrolled in this prospective randomized study. As soon as the EBL exceeded 10% but was less than 20% of the estimated blood volume, the patients were randomly assigned to receive either a volume of lactated Ringer's solution (LRS) equal to three times the EBL (LRS group, n = 22) or a volume of 6% HES equal to the EBL (HES group, n = 20). Tissue oxygenation was assessed indirectly by measuring tonometric parameters, including the difference between gastric intramucosal PsCO(2) and arterial PaCO(2) (Ps-a CO(2) gap), gastric intramucosal pH (pHi) and arterial lactate acid concentration at 30 min after induction of anesthesia (baseline value), 1 hour and 2 hours after skin incision, and at the end of surgery. RESULTS:At the end of surgery,the Ps-a CO(2) gap in the HES group (8.7 +/- 1.6 mmHg) was significantly lower than that of the LRS group (18.74 +/- 4.4 mmHg, P < 0.01), while the pHi (7.30 +/- 0.05 mmHg) in the HES group was significantly higher than that of the LRS group (7.21 +/- 0.07 mmHg, P < 0.01). There was no significant difference between the two groups in terms of arterial lactate acid concentration. CONCLUSION:In patients undergoing major surgery with relatively large blood losses, volume resuscitation with medium molecular weight hydroxyethyl starch solution may improve splanchnic blood flow and tissue oxygenation.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Guo X,Xu Z,Ren H,Luo A,Huang Y,Ye T

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

996-1000

issue

7

eissn

0366-6999

issn

2542-5641

journal_volume

116

pub_type

临床试验,杂志文章,随机对照试验
  • High mobility group box 1 protein: possible pathogenic link to atrial fibrillation.

    abstract::Atrial fibrillation (AF) is the most common sustained dysrhythmia in clinical practice. The bulk of evidence suggests that inflammatory processes, oxidative stress and matrix metalloproteinase are associated with development of AF. However, these agents may be involved in high mobility group box 1 protein (HMGB1). We ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Hu XR,Wang XH,Liu HF,Zhou WJ,Jiang H

    更新日期:2012-07-01 00:00:00

  • Elective single blastocyst transfer is more suitable for normal responders than for high responders.

    abstract:BACKGROUND:Embryo quality and receptivity of the endometrium are two factors that determine the results of in vitro fertilization/intra-cytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). There is no consensus of the optimal transfer strategy for normal responders or high responders. The current study aimed to f...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wu KL,Zhao HB,Liu H,Zhong WX,Yu GL,Chen ZJ

    更新日期:2013-01-01 00:00:00

  • Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice.

    abstract:BACKGROUND:Paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridinium), a widely used herbicide that is structurally similar to the known dopaminergic neurotoxicant MPTP (1-methyl-1, 2, 3, 6-tetrahydropyridine), has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). Aging is an accepte...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li X,Yin J,Cheng CM,Sun JL,Li Z,Wu YL

    更新日期:2005-08-20 00:00:00

  • The role of CTLA4-Ig in a mouse model against allergic asthma.

    abstract:OBJECTIVE:To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig). METHODS:We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wan H,Zhou M,Xu Q,Huang S,Deng W

    更新日期:2003-03-01 00:00:00

  • Performance of K-ras mutation analysis plus endoscopic ultrasound-guided fine-needle aspiration for differentiating diagnosis of pancreatic solid mass: a meta-analysis.

    abstract:BACKGROUND:Difficulties persist in differentiating pancreatic ductal adenocarcinomas (PDAC) from pancreatic inflammatory masses (PIM). Auxiliary diagnostic techniques which enhance the endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) diagnostic yield have been attempted, for example, K-ras mutation analysi...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,meta分析,评审

    doi:

    authors: Xu Y,Hu D,Zhu Q,Sun Y

    更新日期:2014-01-01 00:00:00

  • Genetics of obstructive sleep apnea/hypopnea syndrome.

    abstract:OBJECTIVE:To have a better understanding of genetic contributions to the development of obstructive sleep apnea hypopnea syndrome (OSAHS) by reviewing studies on its genetic basis. DATA SOURCES:A comprehensive search of the PubMed literature without restriction on the publication date was carried out using terms "obst...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang D,Xiao Y,Luo J

    更新日期:2014-01-01 00:00:00

  • Effect of Q-switched alexandrite laser irradiation on dermal melanocytes of nevus of Ota.

    abstract:OBJECTIVE:To investigate the effect of Q-switched alexandrite laser irradiation on dermal melanocytes of nevus of Ota. METHODS:Multiple biopsies were carried out on 4 patients with nevus of Ota before and after laser irradiation. Altogether 11 samples were examined under light microscope and 14 under transmission elec...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lu Z,Chen J,Wang X,Fang L,Jiao S,Huang W

    更新日期:2000-01-01 00:00:00

  • Enteric transmission of transfusion-transmitted virus.

    abstract:OBJECTIVE:To detect the virus in the feces and sera of patients in an outbreak of enterically transmitted non-A, non-E hepatitis, and this review covers the epidemiologic features and experimental infection of this novel virus. DATA SOURCES:Data sources come from our own work on this subject, published and unpublished...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Luo K,Zhang L

    更新日期:2001-11-01 00:00:00

  • A new animal model of coronary thrombosis and effects of antithrombotic agents.

    abstract::The model was established in male rabbits with experimental atherosclerosis, which was induced by diet cholesterol (0.5 g per day for 8 weeks), by means of intravenous injection of one unit of pituitrin (P.P.). To evaluate the effects of aspirin, heparin and viper venom (VV) on this model, 26 male rabbits were divided...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang W,Wang P,Chen Z,Fan Y

    更新日期:1995-05-01 00:00:00

  • Safety and efficacy of a novel technique in the use of fractional flow reserve in complex coronary artery lesions.

    abstract:BACKGROUND:Fractional flow reserve (FFR) has become an increasingly important index when making decisions with respect to revascularization of coronary artery stenosis. However, the pressure guidewire used in obtaining FFR measurements is difficult to control and manipulate in certain complex coronary artery lesions, r...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.152664

    authors: He WM,Li CL,Sun Y,Zhou Z,Mai YF

    更新日期:2015-03-20 00:00:00

  • Subclasses of warm autoantibody IgG in patients with autoimmune hemolytic anemia and their clinical implications.

    abstract:OBJECTIVE:To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA). METHODS:IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies. Hb, TBil, RC and FHb, as hemolytic parameters, were used ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li Z,Shao Z,Xu Y,Shen L,Chen G,Zhang Y,Chu Y

    更新日期:1999-09-01 00:00:00

  • Clinical studies in 500 patients with aortoarteritis.

    abstract::Five hundred patients with aortoarteritis were studied in this series. The long-term administration of small dosage of corticosteroid is effective in treating this disease in its active stage. The patients with renal vascular hypertension should be treated by percutaneous transluminal renal angioplasty or by surgery i...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zheng DY,Liu LS,Fan DJ

    更新日期:1990-07-01 00:00:00

  • Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate.

    abstract:BACKGROUND:Genetic factors can influence antihypertensive response to metoprolol, and many studies focused on the relationship between the genotype in beta1-adrenergic receptor and blood pressure (BP), little was known about the association of angiotensin-converting enzyme (ACE) genotype with the therapeutic result of ...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Liu LW,Liu H,Chen GL,Huang YL,Han LL,Xu ZM,Jiang XJ,Li YS

    更新日期:2010-06-01 00:00:00

  • Association of common polymorphisms in the LRP6 gene with sporadic coronary artery disease in a Chinese population.

    abstract:BACKGROUND:Genetic factors contribute to the development of coronary artery disease (CAD). Recently, a missense mutation in the low density lipoprotein receptor related protein 6 (LRP6) gene, encoding low density lipoprotein receptor related protein 6, has been implicated in an autosomal dominant form of early-onset CA...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang H,Liu QJ,Chen MZ,Li L,Zhang K,Cheng GH,Ma L,Gong YQ

    更新日期:2012-02-01 00:00:00

  • Specific inhibiting effects of Ilexonin A on von Willebrand factor-dependent platelet aggregation under high shear rate.

    abstract:BACKGROUND:Ilexonin A (IA), purified from the Chinese herbal medicine Maodongqing (Ilex pubescens Hook, et Arn) has been commonly used in south China to treat thrombotic disorders. In this study, we aimed to study the inhibiting effects and mechanism of IA on von Willebrand factor (vWF)-dependent high shear-induced pla...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li M,Wu WK,Liu L,Liao FL,Shinohara Y,Handa S,Goto S

    更新日期:2004-02-01 00:00:00

  • The relationship between tumor necrosis factor-alpha gene polymorphisms and acute severe pancreatitis.

    abstract:OBJECTIVE:To investigate the relationship between the presence of the TNF2 allele and plasma concentrations of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptor (sTNF-R) with the development of acute severe pancreatitis (ASP) and severe sepsis. METHODS:Genomic DNA was prepared from peripheral blood leuk...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang D,Li J,Jiang Z,Yu B,Tang X,Li W

    更新日期:2003-11-01 00:00:00

  • Preliminary report on seroepidemiology of HCV and HBV infection in northern China.

    abstract::1 141 serum samples from various population groups in north China were examined for C100-3Ab by ELISA. Antibody to C100-3 antigen derived from HCV genome (C100-3A) and HBsAg were measured in 438 normal population in Beijing. The C100-3Ab positive rate was 2.1% and the HBsAg positive rate was 2.5%. There is increased o...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tao QM,Wang Y,Wang H,Chen WR,Sun Y,Meng Q,Watanabe J,Nishioka K

    更新日期:1992-03-01 00:00:00

  • Gender specific association of neonatal characteristics and cardiovascular risk factors on carotid intima-media thickness in a Chinese cohort.

    abstract:BACKGROUND:Multiple neonatal characteristics and adult cardiovascular risk factors are associated with the development of atherosclerosis, however little conclusive evidence exists characterizing the relative strength of these factors. In a large retrospective study, we investigated the association between both objecti...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lin X,Zhu WL,Tan L,Xu T,Xu RY,Fang Q,Zhang SY,Zhang ZX

    更新日期:2010-09-01 00:00:00

  • Detection of 100% oxygen induced changes in retina using magnetic resonance imaging: a human study.

    abstract:BACKGROUND:Inner retinal oxygenation response (ΔPO(2)) is a worldwide study focus. However, the relevant reports on its radiological measurements are limited. In this study, magnetic resonance imaging (MRI), employing T1 weighted image (T1WI), was used to detect changes in ΔPO(2) following 100% oxygen inhalation in hum...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu QG,Chen QH,Xian JF,Wang ZC

    更新日期:2010-11-01 00:00:00

  • Montelukast improves air trapping, not airway remodeling, in patients with moderate-to-severe asthma: a pilot study.

    abstract:BACKGROUND:Evidence has demonstrated that the distal lung, which includes airways of < 2 mm in diameter and lung parenchyma, constitutes an important component of asthma pathology. Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators and bronchoconstrictors involved in the asthmatic process. Guidelines ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Gao JM,Cai F,Peng M,Ma Y,Wang B

    更新日期:2013-06-01 00:00:00

  • Mid-term effects of lung volume reduction surgery on pulmonary function in patients with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Now lung volume reduction surgery (LVRS) has become one of the most effective methods for the management of some cases of severe chronic obstructive pulmonary disease (COPD). We evaluated the mid-term effects of LVRS on pulmonary function in patients with severe COPD. METHODS:Ten male patients with severe C...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu JM,Yang WL,Jiang GN,Ding JA,Zheng W,Liu WZ,Wang YM,Gao BL,Jiang P,Wu W,Li X,Bjorn J

    更新日期:2007-04-20 00:00:00

  • Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes.

    abstract:BACKGROUND:Chronic heart failure (CHF) and diabetes mellitus portend high morbidity and mortality because of an interrelated pathophysiologic process. This large cohort study aimed to analyze the prevalence, clinical characteristics and long-term outcome of patients with CHF and diabetes. METHODS:A total of 1119 patie...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Shi C,Wang LJ,Hu DF,Li JP,Zhu TQ,Shan Y,Zhao JR,Zhang FR,Shen WF

    更新日期:2010-03-20 00:00:00

  • Clinical significance of co-expression of VEGF-C and VEGFR-3 in non-small cell lung cancer.

    abstract:OBJECTIVE:To investigate the relationship between vascular endothelial growth factor C (VEGF-C) expression, VEGFR-3 expression, lymphangiogenesis and angiogenesis in human non-small cell lung cancer (NSCLC). METHODS:Seventy-six NSCLC samples were stained for VEGF-C, VEGFR-3 and CD34 with immunohistochemical methods. A...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li Q,Dong X,Gu W,Qiu X,Wang E

    更新日期:2003-05-01 00:00:00

  • Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure.

    abstract:BACKGROUND:Studies have shown that β-blockers can improve cardiac performance in heart failure (HF) by reversing protein kinase A (PKA)-mediated sarcoplasmic reticulum (SR) Ca2+ leak. However, it is being strongly questioned as to whether the PKA-mediated ryanodine receptor (RyR2) hyper-phosphorylation is a critical re...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang SJ,Liu ZH,Zou C,Wang L

    更新日期:2012-03-01 00:00:00

  • Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination.

    abstract:BACKGROUND:Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. In order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of bra...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.149194

    authors: Yu SQ,Wang JS,Chen SY,Liu XM,Li Y,Ding YM,Li XY,Sun YL,Chen H

    更新日期:2015-01-20 00:00:00

  • Impact of multidisciplinary team working on the management of colorectal cancer.

    abstract:BACKGROUND:The continual and rapid development of techniques which are used for diagnosis and treatment makes management of colorectal cancer more difficult depending on single discipline. Colorectal cancer multidisciplinary team (MDT) working model is recommended by UK and other countries, but there is little informat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ye YJ,Shen ZL,Sun XT,Wang ZF,Shen DH,Liu HJ,Zhang WL,Chen YL,Zhou J,Poston GJ,Wang S

    更新日期:2012-01-01 00:00:00

  • Value of the pudendal nerves terminal motor latency measurements in the diagnosis of occult stress urinary incontinence.

    abstract:BACKGROUND:Occult stress urinary incontinence may lead to de novo stress urinary incontinence after pelvic floor repair surgery. A measurement of pudendal nerve terminal motor latency can reflect the integrity of the nerves. We aimed to explore the value of pudendal nerve terminal motor latency in the diagnosis of occu...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu L,Hai N,Lang JH,Yu SY,Li B,Wong F

    更新日期:2011-12-01 00:00:00

  • dl-3-n-butylphthalide reduces brain damage in mice with closed head injury.

    abstract:OBJECTIVE:To investigate the protective effect of dl-3-n-butylphthalide (NBP) as an anti-cerebral ischemic drug on brain damage 24 h after closed head injury in mice. METHODS:Closed head injury was induced by dropping a 50-g weight from a height of 18 cm on a metal impounder resting on the parietal bone in mice. RESU...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chong Z,Feng Y

    更新日期:2000-07-01 00:00:00

  • Effect of mitochondrial KATP channel on voltage-gated K+ channel in 24 hour-hypoxic human pulmonary artery smooth muscle cells.

    abstract:BACKGROUND:Hypoxic pulmonary hypertension (HPH) is initiated by inhibition of O2-sensitive, voltage-gated (Kv) channels in pulmonary arterial smooth muscle cells (PASMCs). The mechanism of hypoxic pulmonary hypertension has not yet been fully elucidated. The mitochondrial ATP-sensitive K+ channel (MitoKATP) is extremel...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang T,Zhang ZX,Xu YJ

    更新日期:2005-01-05 00:00:00

  • Endodontic bacteria from primary and persistent endodontic lesions in Chinese patients as identified by cloning and 16S ribosomal DNA gene sequencing.

    abstract:BACKGROUND:Few literatures pertain to the 16S ribosomal DNA (16S rDNA) analysis of bacteria contributing to primary and persistent endodontic lesions, with no information available for the Chinese population. As such, we investigated endodontic bacteria associated with primary and persistent endodontic lesions in adult...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li X,Zhu XF,Zhang CF,Cathro P,Seneviratne CJ,Shen S

    更新日期:2013-02-01 00:00:00