The role of CTLA4-Ig in a mouse model against allergic asthma.

Abstract:

OBJECTIVE:To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig). METHODS:We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge. RESULTS:In the OVA/OVA group, the number of cells, the percentage of inflamed cells and the level of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig. CONCLUSION:Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Wan H,Zhou M,Xu Q,Huang S,Deng W

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

462-4

issue

3

eissn

0366-6999

issn

2542-5641

journal_volume

116

pub_type

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