Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma.

abstract：BACKGROUND:Diffusion tensor imaging (DTI) permits quantitative examination within the pyramidal tract (PT) by measuring fractional anisotropy (FA). To the best of our knowledge, the inter-variability measures of FA along the PT remain unexplained. A clear understanding of these reference values would help radiologists ...

journal_title：Chinese medical journal

authors： Roldan-Valadez E,Rios-Piedra E,Favila R,Alcauter S,Rios C

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence, severity, clinical manifestations and immunological features relevant to liver involvement in 135 cases of primary Sjögren's syndrome. METHODS:One hundred and thirty-five patients with definite primary Sjögren's syndrome were analyzed retrospectively for liver involvement by the ab...

journal_title：Chinese medical journal

authors： Zhang Z,Dong Y

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:The human leukocyte antigen-G (HLA-G) has been considered to be an important tolerogeneic molecule playing an essential role in maternal-fetal tolerance, upregulated in the context of transplantation, malignancy, and inflammation, and has been correlated with various clinical outcomes. The aim of this study ...

journal_title：Chinese medical journal

authors： Xiao L,Zhou WQ,Shi BY,Feng K,He XY,Wei YX,Gao Y,Meng XY,Xiao W

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Corneal dystrophy is a group of inherited blinding diseases of the cornea. This study was to identify the mutations of the keratoepithelin (KE) gene for proper diagnosis of corneal dystrophy. METHODS:Three families with corneal dystrophy were analysed. Thirteen individuals at risk for corneal dystrophy in f...

journal_title：Chinese medical journal

authors： Li Y,Sun XG,Ren HY,Dong B,Wang ZQ,Sun XY

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling ...

journal_title：Chinese medical journal

authors： Wang Y,Xing QQ,Tu JK,Tang WB,Yuan XN,Xie YY,Wang W,Peng ZZ,Huang L,Xu H,Qin J,Xiao XC,Tao LJ,Yuan QJ

更新日期：2019-12-05 00:00:00

abstract：:1 141 serum samples from various population groups in north China were examined for C100-3Ab by ELISA. Antibody to C100-3 antigen derived from HCV genome (C100-3A) and HBsAg were measured in 438 normal population in Beijing. The C100-3Ab positive rate was 2.1% and the HBsAg positive rate was 2.5%. There is increased o...

journal_title：Chinese medical journal

authors： Tao QM,Wang Y,Wang H,Chen WR,Sun Y,Meng Q,Watanabe J,Nishioka K

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Caspases are important in the signaling pathway of cellular apoptosis. Caspase-3 protein expression has been shown to increase and parallel to neuronal apoptosis in retinal ischemia injury. This study was to determine whether caspase-1 is involved in neuronal cell death or in retinal ischemia and reperfusion...

journal_title：Chinese medical journal

authors： Zheng GY,Zhang C,Li ZG

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Gender is one of the risk factors accounting for the high prevalence of adolescent myopia. Considerable research results have shown that myopia incidence of female is higher than that of male. This study aimed to analyze the correlation between ocular parameters and serum estrogen level and to investigate th...

journal_title：Chinese medical journal

authors： Gong JF,Xie HL,Mao XJ,Zhu XB,Xie ZK,Yang HH,Gao Y,Jin XF,Pan Y,Zhou F

更新日期：2015-03-05 00:00:00

abstract：BACKGROUND:The mortality of stroke patients is strongly affected by medical complications. However, there are limited data investigating the effect of in-hospital medical complications on the dependency of stroke patients worldwide. We prospectively and systematically investigated the effect of medical complications on...

journal_title：Chinese medical journal

authors： Wang PL,Zhao XQ,DU WL,Wang AX,Ji RJ,Yang ZH,Wang CX,Liu LP,Wang YL,Ju Y,Wang YJ,China National Stroke Registry (CNSR) investigators.

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To assess whether Angiotensin II (Ang II) and carbon tetrachloride (CCl(4)) used in combination could accelerate the process of fibrosis and whether Ang II play a role in exagerating hepatic fibrosis in rats. METHODS:Ang II was injected into the abdominal cavity of Sprague-Dawley (SD) rats together with subc...

journal_title：Chinese medical journal

authors： Zhou X,Li D,Li X,Lu H,Zhang W

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:In central precocious puberty (CPP), the pulse secretion and release of gonadotropin-releasing hormone (GnRH) are increased due to early activation of the hypothalamic-pituitary-gonadal axis, resulting in developmental abnormalities with gonadal development and appearance of secondary sexual characteristics....

journal_title：Chinese medical journal

authors： Li WJ,Gong CX,Guo MJ,Xing J,Li T,Song WH,Luo XP,Wu D,Liang JP,Cao BY,Gu Y,Su C,Liang XJ,Liu M,Wang R,Li FT

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Tbx1 is the major candidate gene for DiGeorge syndrome (DGS). Similar to defects observed in DGS patients, the structures disrupted in Tbx1(-/-) animal models are derived from the neural crest cells during development. Although the morphological phenotypes of some Tbx1 knock-down animal models have been well...

journal_title：Chinese medical journal

authors： Zhang LF,Gui YH,Wang YX,Jiang Q,Song HY

更新日期：2010-05-05 00:00:00

abstract：BACKGROUND:Many studies suggest that the gamma irradiation decreases allograft strength in a dose-dependent manner. However, no study has demonstrated that this decrease in strength translates into higher failure rate in meniscal allograft transplantation (MAT). The aim of this study was to investigate the effects of g...

journal_title：Chinese medical journal

authors： Zhang J,Song GY,Chen XZ,Li Y,Li X,Zhou JL

更新日期：2015-05-20 00:00:00

abstract：OBJECTIVE:To study the preventive effect of artemether (Art) in protecting the people from schistosome infection during flood fighting in schistosomiasis endemic area of Poyang Lake, Jiangxi Province. METHODS:From mid July to mid August in 1996, the water level in Poyang Lake rose due to torrential rains and 2 embankm...

journal_title：Chinese medical journal

authors： Song Y,Xiao S,Wu W,Zhang S,Xie H,Xu X,Hu X,Cui Q,Chen M,Zheng J

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Urine output (UO) is an essential criterion of the Kidney Disease Improving Global Outcomes (KDIGO) definition and classification system for acute kidney injury (AKI), of which the diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria (KDIGOUO) could ...

journal_title：Chinese medical journal

authors： Qin JP,Yu XY,Qian CY,Li SS,Qin TH,Chen EZ,Lin JD,Ai YH,Wu DW,Liu DX,Sun RH,Hu ZJ,Cao XY,Zhou FC,He ZY,Zhou LH,An YZ,Kang Y,Ma XC,Zhao MY,Jiang L,Xu Y,Du B,China Critical Care Clinical Trial Group (CCCCTG).

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Traditionally, displaced greater tuberosity fractures are treated with open reduction and internal fixation. Arthroscopic treatment and outcome of greater tuberosity fractures is far from comprehensive. The objective of the current study was to assess the surgical procedure and outcome of an arthroscopic met...

journal_title：Chinese medical journal

authors： Wang YP,Zhao JZ,Huangfu XQ,Liu WX,Jiang Y,Zhou XH,He YH

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of misoprostol in term labour induction. DATA SOURCES:Data from published English and Chinese literatures about misoprostol in term labour induction were identified from Medline and CBMdisk (using the search terms "misoprostol" and "labour induction") before 2001; hand sea...

journal_title：Chinese medical journal

authors： Li XM,Wan J,Xu CF,Zhang Y,Fang L,Shi ZJ,Li K

更新日期：2004-03-01 00:00:00

abstract：Background:Patients with major depressive disorder (MDD) usually have high risk of suicidality. Few studies have investigated the effects of stressful life events (SLEs) on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese pati...

journal_title：Chinese medical journal

authors： Lin JY,Huang Y,Su YA,Yu X,Lyu XZ,Liu Q,Si TM

更新日期：2018-04-20 00:00:00

abstract：:From 1949 through 1978, 31 patients with renal metastasis were diagnosed in a total of 448 cases of choriocarcinoma admitted to our hospital, giving an incidence of 6.9%. Renal metastasis was invariably preceded by pulmonary metastases and usually accompanied by other visceral metastases, indicating that renal metasta...

journal_title：Chinese medical journal

authors： Wang YE,Song HZ,Yang XY,Dong SY,Gan N

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:There is no detailed report about the angiographic leakage of polypoidal choroidal vasculopathy (PCV) lesions on indocyanine green (ICG) angiography. This study aimed to investigate the angiographic leakage of polypoidal lesions in PCV on ICG angiography. METHODS:One hundred and forty-four eyes of 137 patie...

journal_title：Chinese medical journal

authors： Zuo CG,Wen F,Huang SZ,Luo GW,Yan H,Wu WJ,Wu DZ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem or stromal cells (MSCs) derived from the induced pluripotent stem cells (iPSCs) have uniform biological activity, which makes the clinical application of MSCs in bone repair possible. Culturing the iPSC-MSCs onto osteoconductive materials is a promising tissue engineering-based strategy in b...

journal_title：Chinese medical journal

authors： Li JY,Wang TT,Li C,Wang ZF,Li S,Ma L,Zheng LL

更新日期：2020-02-05 00:00:00

abstract：OBJECTIVE:To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats. METHODS:Male Sprague Dawley (SD) rats were scheduled to undergo 3-hour middle cerebral artery occlusion by intraluminal suture and 24-hour reperfusio...

journal_title：Chinese medical journal

authors： Chen L,Gong Q,Xiao C

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Carotid stenosis is one of the common reasons for patients with ischemic stroke, and the two invasive options carotid endarterectomy (CEA) and carotid artery stenting (CAS) are the most popular treatments. But the relative efficacy and safety of the methods are not clear. METHODS:About 521 articles related ...

journal_title：Chinese medical journal

authors： Wang L,Liu XZ,Liu ZL,Lan FM,Shi WC,Liu J,Zhang JN

更新日期：2013-02-01 00:00:00

abstract：:Patients whose routine MRI were negative but were clinically highly suspected of having intra-cranial or intra-spinal canal space-occupying lesions, and those whose routine MRI were positive but presented difficulties in defining the contour or the nature of the lesion, or difficulty in distinguishing the lesion from ...

journal_title：Chinese medical journal

authors： Shen TZ,Mei H,Huang XL,Chen XR

更新日期：1991-04-01 00:00:00

abstract：:In present study, we examined the effects of NG-nitro-L-arginine (LNNA), an inhibitor of nitric oxide synthase (NOS), and/or methylene blue (MB), a blocker of guanylate cyclase on the vasodilator response of isolated rat arteries including aorta and mesenteric artery to calcitonin gene-related peptide (CGRP) by in vit...

journal_title：Chinese medical journal

authors： Tan DY,Zhang LZ,Zhao YT,Zhao D,Tang J

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:To study the status of cochlear mitochondrial DNA (mtDNA) and to determine the location of mtDNA deletion in aged mice. METHODS:We detected cochlear mtDNA in 2, 7 - 10 and 17 - 19 month old mice by nested polymerase chain reaction (PCR) and DNA sequencing. RESULTS:mtDNA3867bp deletions were found in the co...

journal_title：Chinese medical journal

authors： Zhang X,Han D,Ding D,Dai P,Yang W,Jiang S,Salvi RJ

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:One of the reasons for poor neuroregeneration after central nervous system injury is the presence of inhibitory factors such as Nogo. Here, we tested the inhibition of Nogo by RNA interference both in vitro and in vivo, using recombinant adenovirus-mediated transfection of short hairpin RNAs, to explore a ne...

journal_title：Chinese medical journal

authors： Sun HH,Gao F,Liu B,Yu HT,Kong N,Liu GM

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Human urotensin II (UII) is the most potent mammalian vasoconstrictor identified so far. Our previous study showed that UII is a potent mitogen of airway smooth muscle cells (ASMC) inducing ASMC proliferation in a dose-dependent manner. The signal transduction pathway of UII mitogenic effect remains to be cl...

journal_title：Chinese medical journal

authors： Chen YH,Zhao MW,Yao WZ,Pang YZ,Tang CS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Roundabout 5 (R5) is a monoclonal antibody which can neutralize the binding of Roundabout 1 (Robo1) to Slit2. Oral squamous cell carcinoma angiogenesis was significantly inhibited when R5 blocked slit-robo signaling pathway. However, the effect of R5 on the invasion of tongue cancer cells has not been invest...

journal_title：Chinese medical journal

authors： Xiao R,Zhao Y,Wang LJ,Li WP

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) contributes greatly to renal tubulointerstitial fibrosis, which is the final event leading to end-stage renal failure. This study was designed to investigate the effects of CTGF antisense oligodeoxynucleotides (ODNs) on the expressions of plasminogen activator inhibitor...

journal_title：Chinese medical journal

authors： Zhang C,Meng XF,Zhu ZH,Yang X,Deng AG

更新日期：2004-07-01 00:00:00