Abstract:
BACKGROUND:Excessive expression of thymic stromal lymphopoietin (TSLP) has been demonstrated in asthmatic airway epithelia and in nasal epithelia from animal models of allergic rhinitis (AR), but the evidence of expression of TSLP in nasal epithelial cells (NECs) of patients with AR is lacking. We aimed to investigate the expression of TSLP in NECs of patients with mugwort sensitive-seasonal AR and determine whether it is associated with severity of symptoms and the number of infiltrated eosinophils in nasal mucosa. METHODS:NECs specimens were obtained by scraping with plastic curettes from the nasal inferior turbinates of patients with mugwort pollen sensitive-seasonal AR (n = 22) and nonallergic controls (n = 11) during last peak mugwort pollen season. The severity of nasal symptom was assessed using a Visual Analog Scale (VAS). In addition, serum mugwort pollen IgE levels were tested from each patient. In situ hybridization (ISH) was performed to test the messenger RNA (mRNA) of TSLP in the NECs. Furthermore, immunohistochemical staining (IHC) was scored to evaluate the expression of TSLP and eosinophil cell count was made by May-Grünwald/Giemsa staining. The correlation between expression of TSLP and all other parameters was analyzed in this study. RESULTS:The mRNA level of TSLP was significantly increased in NECs of patients with AR compared with the nonallergic control group (P < 0.05). In addition, IHC results showed that expression of TSLP in NECs from patients with AR was up-regulated which was correlated with VAS score (r = 0.598; P < 0.05) and nasal eosinophils count (r = 0.702; P < 0.05), but it was unrelated with mugwort pollen specific IgE level. CONCLUSIONS:These preliminary findings indicate a potential relationship between TSLP expression, severity of symptoms and nasal eosinophils count in pathogenesis of AR, but TSLP expression did not correlate with mugwort pollen specific IgE level. The elevated expression of TSLP might play a critical role in local atopical responses of AR. In the future, the TSLP has the potential to be one of the most important molecular markers for AR diagnoses and assessment.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Zhu DD,Zhu XW,Jiang XD,Dong Zsubject
Has Abstractpub_date
2009-10-05 00:00:00pages
2303-7issue
19eissn
0366-6999issn
2542-5641journal_volume
122pub_type
杂志文章abstract:BACKGROUND:Gastric varices (GV) are life-threatening for patients with portal hypertension. Endoscopic injection with butyl cyanoacrylate (BC), the mainstay of the therapy for GV, has been reported to be effective for hemostasis of bleeding varices, but its efficacy in the obliteration of GV and impact on the survival ...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2007-12-05 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
doi:
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更新日期:2015-12-05 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
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doi:
更新日期:2005-08-20 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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doi:
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pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章
doi:
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Chinese medical journal
pub_type: 杂志文章,随机对照试验
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