Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes.

Abstract:

BACKGROUND:Chronic heart failure (CHF) and diabetes mellitus portend high morbidity and mortality because of an interrelated pathophysiologic process. This large cohort study aimed to analyze the prevalence, clinical characteristics and long-term outcome of patients with CHF and diabetes. METHODS:A total of 1119 patients with NYHA functional class II - IV and left ventricular ejection fraction (LVEF) < 45% between January 1995 and May 2009 were recruited. Clinical variables, biochemical and echocardiographic measurements were retrospectively reviewed, and composite major cardiac events (MCE) including death, heart transplantation, and refractory heart failure requiring multiple hospitalizations were recorded. RESULTS:The prevalence of CHF with diabetes was progressively increased with time (16.9% in 1995 - 1999; 20.4% in 2000 - 2004, and 29.1% in 2005 - 2009) and age (18.5% in < 60 years, 26.6% in 60 - 80 years, and 26.6% in > 80 years). Compared with CHF patients without diabetes, those with diabetes had worse cardiac function, more abnormal biochemical changes, and higher mortality. Treatment with glucose-lowering agents significantly improved LVEF and decreased MCE. An elevated serum HbA1c level was associated with large left ventricular end-systolic diameter (P < 0.05), decreased LVEF (P < 0.01) and reduced survival (P < 0.05). Multivariable Logistic regression analysis revealed that after adjustment for confounding factors, NYHA functional class (OR 2.65, 95%CI 1.14 - 6.16, P = 0.024) and HbA1c level >or= 7% (OR 2.78, 95%CI 1.00 - 7.68, P = 0.049) were independent risk factors for adverse outcomes in CHF patients with diabetes. CONCLUSIONS:Prevalence of CHF with diabetes was increasing during past decades, and patients with CHF and diabetes had worse clinical profiles and prognosis. Aggressive anti-CHF and diabetes therapies are needed to improve overall outcomes for these patients.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Shi C,Wang LJ,Hu DF,Li JP,Zhu TQ,Shan Y,Zhao JR,Zhang FR,Shen WF

subject

Has Abstract

pub_date

2010-03-20 00:00:00

pages

646-50

issue

6

eissn

0366-6999

issn

2542-5641

journal_volume

123

pub_type

杂志文章
  • Investigation of herpes simplex virus type-1 latency in corneas.

    abstract::The recurrent rate of herpes simplex keratitis (HSK) was 4.17% after penetrating keratoplasty (PKP) was performed in 216 patients with HSK; the mean period of follow-up was 6.5 years. Immunohistochemical technique showed that HSV-1 antigens were present in the corneal stroma of rabbit eyes up to 45 days after primary ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xie LX,Dong XG,Kaufman HE

    更新日期:1993-04-01 00:00:00

  • Rationale and study design for one-stop assessment of renal artery stenosis and renal microvascular perfusion with contrast-enhanced ultrasound for patients with suspected renovascular hypertension.

    abstract:BACKGROUND:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP). However, few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP. Thus, this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for a...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000000002

    authors: Ren JH,Ma N,Wang SY,Sun YJ,Zhang YW,Guo FJ,Li YJ,Li TH,Ai H,Zhang WD,Li P,Ma WH

    更新日期:2019-01-05 00:00:00

  • Mutation analysis of potassium channel genes KCNQ1 and KCNH2 in patients with long QT syndrome.

    abstract:OBJECTIVE:To determine mutations of two common potassium channel subunit genes KCNQ1, KCNH2 causing long QT syndrome (LQTS) in the Chinese. METHODS:Thirty-one Chinese LQTS pedigrees were characterized for mutations in the two LQTS genes, KCNQ1 and KCNH2, by sequencing. RESULTS:Two novel KCNQ1 mutations, S277L in the ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu W,Hu D,Li C,Li P,Li Y,Li Z,Li L,Qin X,Dong W,Qi Y,Chen S,Wang Q

    更新日期:2003-09-01 00:00:00

  • Comparison of results of laser and routine surgery therapy in treatment of nasal polyps.

    abstract::102 patients with nasal polyps receiving ND: YAG laser surgery or routine surgery were followed up for 18-36 months. The postoperative recurrence rates were 40.6% (24/54) and 66.6% (32/48) respectively for the patients of the two groups. Laser surgery is marked by less bleeding, no postoperative packing of the nose an...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang BQ

    更新日期:1993-09-01 00:00:00

  • Neutrophil to lymphocyte ratio is a prognosis factor for post-operative pneumonia in aneurysmal subarachnoid hemorrhage patients.

    abstract:BACKGROUND:Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm (post-operative pneumonia [POP]) in patients with aneurysmal subarachnoid hemorrhage (aSAH) have been studied, the predictive model of POP after aSAH has still not been well established. Thus, the aim of this study was ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000001304

    authors: Chen Y,Lian BQ,Peng L,Ding CY,Lin YX,Yu LH,Wang DL,Kang DZ

    更新日期:2020-12-24 00:00:00

  • Expressed sequence tags analysis of a liver tissue cDNA library from a highly inbred minipig line.

    abstract:BACKGROUND:Porcine liver performing efficient physiological functions in the human body is prerequisite for successful liver xenotransplantation. However, the protein differences between pig and human remain largely unexplored. Therefore, we investigated the liver expression profile of a highly inbred minipig line. ME...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen YN,Tan WD,Lu YR,Qin SF,Li SF,Zeng YZ,Bu H,Li YP,Cheng JQ

    更新日期:2007-05-05 00:00:00

  • P53 gene abnormalities in osteosarcoma.

    abstract:OBJECTIVE:The P53 tumor suppressor gene shows the most frequent genetic alteration in human tumors. Mutation, deletion and rearrangement of P53 gene have been found in several types of neoplasm including osteosarcoma. The present study is to clarify the status of abnormalities of this gene in osteosarcoma in China. MA...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Guo W,Wang X,Feng C

    更新日期:1996-10-01 00:00:00

  • Efficacy and safety of the treatment: combination of benazepril/lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension.

    abstract:BACKGROUND:Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension. This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension. METHODS:One hundred and eighty-...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Chen T,Chen GH,Yang TS,Zhong ZY,An WS,Zhang XX,Li JD

    更新日期:2013-06-01 00:00:00

  • Thin-section computed tomography detects long-term pulmonary sequelae 3 years after novel influenza A virus-associated pneumonia.

    abstract:BACKGROUND:The aim of this research was to evaluate long-term pulmonary sequelae on paired inspiration-expiration thin-section computed tomography (CT) scans 3 years after influenza A (H1N1) virus-associated pneumonia, and to analyze the affecting factors on pulmonary fibrosis. METHODS:Twenty-four patients hospitalize...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.154285

    authors: Xing ZH,Sun X,Xu L,Wu Q,Li L,Wu XJ,Shao XG,Zhao XQ,Wang JH,Ma LY,Wang K

    更新日期:2015-04-05 00:00:00

  • Relationship between the renin-angiotensin system genes and diabetic nephropathy in the Chinese.

    abstract:OBJECTIVE:To clarify whether genetic variants of the renin-angiotensin system (RAS) contribute to the development of diabetic nephropathy (DN) in the Chinese. METHODS:Totally 173 Chinese subjects of Han nationality from Shanghai were classified into! control, DN (-) and DN (+) groups. The latter was subdivided accordi...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wu S,Xiang K,Zheng T,Sun D,Weng Q,Zhao H,Li J

    更新日期:2000-05-01 00:00:00

  • Genotyping and preparation of the recombinant nucleocapsid protein antigen of hantavirus.

    abstract:OBJECTIVE:To identify new recombinant antigens with potential for diagnosis of hemorrhagic fever with renal syndrome (HFRS) and establish reverse transcription-polymerase chain reaction-restriction fragments length polymorphism (RT-PCR-RFLP) for genotyping of hantavirus. METHODS:One group of primers was used to clone ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tang J,Cao M,Tang T,Wang C,Wei C,Lei W

    更新日期:2001-10-01 00:00:00

  • Continuous long-term albendazole therapy in intraabdominal cystic echinococcosis.

    abstract:OBJECTIVE:To assess the therapeutic effects of long-term albendazole therapy in intraabdominal cystic echinococcosis. METHODS:Fifteen patients with a total of 45 cysts were treated with albendazole with dosage regimen of 20 mg.kg-1.d-1 for an average of 2.5 years. Repeated CT and ultrasound scannings (US) were perform...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu Y,Wang X,Wu J

    更新日期:2000-09-01 00:00:00

  • Outcome of surgery for sinus of Valsalva aneurysm with discrete membranous subaortic stenosis.

    abstract:BACKGROUND:Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly, and SVA with discrete membranous subaortic stenosis is even rarer. The aim of the study was to make sure the incidence of SVA with discrete membraneous subaortic stenosis in SVA and their surgical results. We retrospectively analyzed 234 patients re...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Guo HW,Chang Q,Yu CT,Sun XG,Qian XY,Hu SS

    更新日期:2012-05-01 00:00:00

  • Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases.

    abstract:BACKGROUND:Exposure of adult mice to more than 95% O(2) produces a lethal injury by 72 hours. Nitric oxide synthase (NOS) is thought to contribute to the pathophysiology of murine hyperoxia-induced acute lung injury (ALI). Osteopontin (OPN) is a phosphorylated glycoprotein produced principally by macrophages. OPN inhib...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang XF,Liu S,Zhou YJ,Zhu GF,Foda HD

    更新日期:2010-04-05 00:00:00

  • Polymorphism on chromosome 9p21.3 contributes to early-onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients.

    abstract:BACKGROUND:Susceptibility to coronary artery disease (CAD) and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and witho...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.3901/jme.2011.08.066

    authors: Wang W,Peng WH,Lu L,Zhang RY,Zhang Q,Wang LJ,Chen QJ,Shen WF

    更新日期:2011-01-01 00:00:00

  • Predictors to assess non-sentinel lymph node status in breast cancer patients with only one sentinel lymph node metastasis.

    abstract:BACKGROUND:The purpose of this study was to investigate the feasibility of avoiding axillary lymph node dissection (ALND) for patients with only one sentinel lymph node (SLN) metastasis. The characteristics and predictive factors for non-sentinel lymph node (NSLN) metastasis of patients with single positive SLN were al...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yang B,Yang L,Zuo WS,Ge WK,Zheng G,Zheng MZ,Yu ZY,Wang YS

    更新日期:2013-02-01 00:00:00

  • Calcium channel blockers in cirrhotic patients with portal hypertension.

    abstract::Four calcium channel blockers, i.e. nifedipine, verapamil, cinnarizine and tetrandrine are currently available and used widely in treating cardiovascular diseases. To confirm the effects, if any, of calcium channel blockers on cirrhotic patients with portal hypertension, a study was performed on esophageal variceal pr...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Li D,Lu H,Li X,Quan Q,Li X,Lu W

    更新日期:1995-11-01 00:00:00

  • Involvement of nitric oxide in the vasodilator and depressor effect of calcitonin gene-related peptide.

    abstract::In present study, we examined the effects of NG-nitro-L-arginine (LNNA), an inhibitor of nitric oxide synthase (NOS), and/or methylene blue (MB), a blocker of guanylate cyclase on the vasodilator response of isolated rat arteries including aorta and mesenteric artery to calcitonin gene-related peptide (CGRP) by in vit...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tan DY,Zhang LZ,Zhao YT,Zhao D,Tang J

    更新日期:1994-10-01 00:00:00

  • Pathologic analysis of preterm delivery placentas.

    abstract::198 preterm delivery placentas of 28 weeks to less than 37 weeks pregnancy were analyzed. Gross examination revealed that the differences of placenta previa and low implantation (2.91%), bipartate placenta and rupture of marginal sinus (0.97% respectively), large placenta (2.91%), short cord (4.85%), velamentous inser...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tang MY

    更新日期:1990-10-01 00:00:00

  • Percutaneous balloon mitral valvuloplasty. An observation of 50 patients.

    abstract::Percutaneous balloon mitral valvuloplasty (PBMV) was successfully performed in 50 selected patients with mitral stenosis by using Inoue pillow-shaped balloon and Inoue technique. The average diameter of balloon used was 26.9 +/- 0.9 mm. 90% (45/50) of cases had either double or single mitral commissura split. Of the r...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Fang WY,Yu WX,Lu ZX,Li XM,Bu DX,Xu WL

    更新日期:1994-09-01 00:00:00

  • Detection of SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction.

    abstract:OBJECTIVE:To assess the feasibility of detecting SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction (RT-PCR). METHODS:RT-PCR was used to amplify the SYT-SSX fusion transcripts using archival formalin-fixed paraffin-embedded tumor specimens fro...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wei Y,Wang J,Zhu X,Shi D,Hisaoka M,Hashimoto H

    更新日期:2002-07-01 00:00:00

  • Heliox as a driving gas to atomize inhaled drugs on acute exacerbation of chronic obstructive pulmonary disease: a prospective clinical study.

    abstract:BACKGROUND:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common condition, which affects not only the quality of life of patients but also their prognosis. The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the gluco...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xiao Y,Su L,Han B,Zhang X,Xie L

    更新日期:2014-01-01 00:00:00

  • Anastomotic false aneurysm following abdominal aortic aneurysmectomy and prosthetic grafting.

    abstract::Anastomotic false aneurysm (AFA) of the aorta is a potentially lethal complication after prosthetic grafting. Nineteen aneurysms were encountered in 18 patients within a 30-year period (1960-1991). There were 10 men and 8 women, aged 27-80 years (mean 58 years). In 14 patients, the prostheses were made of silk, in 2 w...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen FZ,Xu X,Fu WG,Wu ZG

    更新日期:1994-11-01 00:00:00

  • Preliminary results of combined carotid endarterectomy and off-pump coronary artery bypass grafting in patients with coexistent carotid and coronary artery diseases.

    abstract:BACKGROUND:Coexistent carotid and coronary artery diseases are common and patients with them remain at a high risk for perioperative stroke or myocardial infarction after coronary bypass surgery. The aim of this study was to investigate the effect of combined carotid endarterectomy (CEA) and off-pump coronary artery by...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen XJ,Chen X,Xie DH,Shi KH,Xu M

    更新日期:2009-12-20 00:00:00

  • Influence of CaNa2 EDTA on topical 5-aminolaevulinic acid photodynamic therapy.

    abstract:BACKGROUND:We assessed whether the CaNa2 EDTA could improve the accumulation of protoporphyrin IX (PpIX) and photosensitisation in HEp-2 cells as well as the depth of treatment of skin cancers on the topical 5-Aminolaevulinic acid (5-ALA) PDT. METHODS:HEp-2 cells were incubated with 5-ALA (0-1 mmol/L) and CaNa2EDTA (0...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu HF,Xu SZ,Zhang CR

    更新日期:2004-06-01 00:00:00

  • Transitional cell carcinoma associated with aristolochic acid nephropathy: most common cancer in chronic hemodialysis patients in China.

    abstract:BACKGROUND:The research of cancer in patients on hemodialysis (HD) in China has not been reported. The aim of this study was to investigate the clinical and histological features and outcomes of cancer in Chinese HD patients. METHODS:The study subjects were 49 cancer patients (1.4%) out of 3448 end stage renal disease...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhou L,Cao YL,Li WG,Fu FT,Zhang L,Wang X,Shi XH

    更新日期:2012-12-01 00:00:00

  • Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate.

    abstract:BACKGROUND:Genetic factors can influence antihypertensive response to metoprolol, and many studies focused on the relationship between the genotype in beta1-adrenergic receptor and blood pressure (BP), little was known about the association of angiotensin-converting enzyme (ACE) genotype with the therapeutic result of ...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Liu LW,Liu H,Chen GL,Huang YL,Han LL,Xu ZM,Jiang XJ,Li YS

    更新日期:2010-06-01 00:00:00

  • Endovascular embolization of pulmonary arteriovenous malformations.

    abstract:BACKGROUND:The major consequence of pulmonary arteriovenous malformations (PAVMs) is the direct inflow of blood from the pulmonary artery to the pulmonary vein which induces hypoxemia. Severe complications include transient ischemic attacks, paradoxical embolization in the central nervous system, massive hemoptysis or ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu FY,Wang MQ,Fan QS,Duan F,Wang ZJ,Song P

    更新日期:2010-01-05 00:00:00

  • Unsatisfactory Glucose Management and Adverse Pregnancy Outcomes of Gestational Diabetes Mellitus in the Real World of Clinical Practice: A Retrospective Study.

    abstract:Background:Facing the increasing prevalence of gestational diabetes mellitus (GDM), this study aimed to evaluate the management of GDM and its association with adverse pregnancy outcomes. Methods:The data of 996 inpatients with GDM who terminated pregnancies in our hospital from January 2011 to December 2015 were coll...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.230718

    authors: Feng R,Liu L,Zhang YY,Yuan ZS,Gao L,Zuo CT

    更新日期:2018-05-05 00:00:00

  • Intermittent Oxygen Inhalation with Proper Frequency Improves Overall Health Conditions and Alleviates Symptoms in a Population at High Risk of Chronic Mountain Sickness with Severe Symptoms.

    abstract:BACKGROUND:Oxygen inhalation therapy is essential for the treatment of patients with chronic mountain sickness (CMS), but the efficacy of oxygen inhalation for populations at high risk of CMS remains unknown. This research investigated whether oxygen inhalation therapy benefits populations at high risk of CMS. METHODS...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/0366-6999.182831

    authors: Feng B,Xu WH,Gao YQ,Liu FY,Li P,Zheng SJ,Gai LY,Zhang G

    更新日期:2016-06-05 00:00:00