Calcium channel blockers in cirrhotic patients with portal hypertension.

Abstract:

:Four calcium channel blockers, i.e. nifedipine, verapamil, cinnarizine and tetrandrine are currently available and used widely in treating cardiovascular diseases. To confirm the effects, if any, of calcium channel blockers on cirrhotic patients with portal hypertension, a study was performed on esophageal variceal pressure and rebleeding rate of esophageal varices after 2 years by using calcium channel blocker in 321 patients from some 23 hospitals. The results demonstrated that the calcium channel blockers could significantly reduce the esophageal variceal pressure and the portal blood flow in cirrhotic patients with portal hypertension. The proportion of patients with no recurrent gastrointestinal bleeding after 2 years medication of tetrandrine was 87.9% in tetrandrine group, significantly higher than those in the other 4 groups (P < 0.05). It is suggested that tetrandrine should be more effective for cirrhotic patients with portal hypertension in preventing recurrent variceal bleeding.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Li D,Lu H,Li X,Quan Q,Li X,Lu W

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

803-8

issue

11

eissn

0366-6999

issn

2542-5641

journal_volume

108

pub_type

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