Calcium channel blockers in cirrhotic patients with portal hypertension.

Abstract:

:Four calcium channel blockers, i.e. nifedipine, verapamil, cinnarizine and tetrandrine are currently available and used widely in treating cardiovascular diseases. To confirm the effects, if any, of calcium channel blockers on cirrhotic patients with portal hypertension, a study was performed on esophageal variceal pressure and rebleeding rate of esophageal varices after 2 years by using calcium channel blocker in 321 patients from some 23 hospitals. The results demonstrated that the calcium channel blockers could significantly reduce the esophageal variceal pressure and the portal blood flow in cirrhotic patients with portal hypertension. The proportion of patients with no recurrent gastrointestinal bleeding after 2 years medication of tetrandrine was 87.9% in tetrandrine group, significantly higher than those in the other 4 groups (P < 0.05). It is suggested that tetrandrine should be more effective for cirrhotic patients with portal hypertension in preventing recurrent variceal bleeding.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Li D,Lu H,Li X,Quan Q,Li X,Lu W

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

803-8

issue

11

eissn

0366-6999

issn

2542-5641

journal_volume

108

pub_type

临床试验,杂志文章,随机对照试验
  • Stable transfection of estrogen receptor-alpha suppresses expression of cyclooxygenase-2 and vascular endothelial growth factor-C in MDA-MB-231 breast cancer cells.

    abstract:BACKGROUND:Estrogen receptor (ER)-negative breast cancer cells are more aggressive than ER-positive cells. Elevated levels of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-C (VEGF-C) expression have been detected in cultured human breast cancer cells and are associated with negative hormone receptor s...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang H,Lin Y,Xiao Y,Wang SM,Liu XX,Wang SM

    更新日期:2010-08-05 00:00:00

  • Uncommon characteristics of the structure and development of Trichosporon asahii.

    abstract:BACKGROUND:Trichosporon asahii (T. asahii) is one of the most important pathogenic fungus in the genus of trichosporon. Although the species identification of T. asahii was based upon the complicated results of morphologic, biochemical and biologic examination, the morphology characteristic is still the first clue to t...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang WL,Yang RY,Ao JH

    更新日期:2009-08-05 00:00:00

  • Optimal microsurgical treatment of dorsum sellae meningioma.

    abstract:BACKGROUND:There are few reports of microsurgical treatment of dorsum sellae meningiomas-which, because of location, size, and differences in growth direction, clinical presentations, degree of surgical difficulty, have varied posttreatment sequelae. In pursuit of an optimal microsurgical treatment option for dorsum se...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Geng SM,Zhang JT,Zhang LW,Wu Z,Wang ZC

    更新日期:2009-08-20 00:00:00

  • PET/CT imaging of delayed radiation encephalopathy following radiotherapy for nasopharyngeal carcinoma.

    abstract:BACKGROUND:With the significant improvement in the survival of patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy and the growing availability of the sophisticated imaging modalities, the number of radiation encephalopathy (RE) cases relating to NPC radiotherapy is increasing. In this study, we invest...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang XL,Yin JL,Li H,Li XD,Quan JT

    更新日期:2007-03-20 00:00:00

  • Clinical, brain electric earth map, endothelin and transcranial ultrasonic Doppler findings after hyperbaric oxygen treatment for severe brain injury.

    abstract:OBJECTIVE:To analyze the effect and mechanism of hyperbaric oxygen (HBO) treatment for severe brain injury (SBI). METHODS:Fifty-five patients were divided into a treatment group of 35 patients and a control group of 20 patients. We observed the alterations of clinical, brain electric earth map (BEAM), endothelin (ET) ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ren H,Wang W,Ge Z,Zhang J

    更新日期:2001-04-01 00:00:00

  • Morphological evidence of telocytes in mice aorta.

    abstract:BACKGROUND:Telocytes (TCs) are a novel type of interstitial cells, which have been recently described in a large variety of cavitary and noncavitary organs. TCs have small cell bodies, and remarkably thin, long, and moniliform prolongations called telopodes (Tps). Until now, TCs have been found in various loose connect...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.150102

    authors: Zhang HQ,Lu SS,Xu T,Feng YL,Li H,Ge JB

    更新日期:2015-02-05 00:00:00

  • Pretreatment with repeated electroacupuncture attenuates transient focal cerebral ischemic injury in rats.

    abstract:OBJECTIVE:To investigate whether pretreatment with repeated electroacupuncture (EA) at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats. METHODS:Thirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consis...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xiong L,Lu Z,Hou L,Zheng H,Zhu Z,Wang Q,Chen S

    更新日期:2003-01-01 00:00:00

  • Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China.

    abstract:BACKGROUND:The Xpert MTB/RIF showed high sensitivity and specificity in previous studies carried out in different epidemiological and geographical settings and patient populations in high-burden tuberculosis (TB) countries. However, there were little data obtained by validation or demonstration study of the assay in Ch...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Hu P,Bai L,Liu F,Ou X,Zhang Z,Yi S,Chen Z,Gong D,Liu B,Guo J,Tan Y

    更新日期:2014-01-01 00:00:00

  • E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.

    abstract:BACKGROUND:Marked interindividual variation exists in blood pressure response to benazepril, which is considered to have genetic basis. Our objectives were to evaluate whether the E112D polymorphism in the prolylcarboxypeptidase (PRCP) gene has impact on blood pressure response to benazepril. METHODS:Hypertensive pati...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang Y,Hong XM,Xing HX,Li JP,Huo Y,Xu XP

    更新日期:2009-10-20 00:00:00

  • Human LINE1 endonuclease domain as a putative target of SARS-associated autoantibodies involved in the pathogenesis of severe acute respiratory syndrome.

    abstract:BACKGROUND:Severe acute respiratory syndrome (SARS) is a disease with a mortality of 9.56%. Although SARS is etiologically linked to a new coronavirus (SARS-CoV) and functional cell receptor has been identified, the pathogenesis of the virus infection is largely unclear. METHODS:The clinical specimens were processed a...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: He WP,Shu CL,Li BA,Zhao J,Cheng Y

    更新日期:2008-04-05 00:00:00

  • P53 gene abnormalities in osteosarcoma.

    abstract:OBJECTIVE:The P53 tumor suppressor gene shows the most frequent genetic alteration in human tumors. Mutation, deletion and rearrangement of P53 gene have been found in several types of neoplasm including osteosarcoma. The present study is to clarify the status of abnormalities of this gene in osteosarcoma in China. MA...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Guo W,Wang X,Feng C

    更新日期:1996-10-01 00:00:00

  • Emergency off-pump coronary artery surgery.

    abstract:BACKGROUND:Off-pump coronary artery bypass grafting is fast-becoming a procedure of choice for elective revascularization in high-risk patients with multi-vessel coronary artery disease. However, the role of off-pump coronary artery bypass grafting for patients with acute coronary syndromes requiring emergency revascul...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Raja SG,Haider Z,Zaman H

    更新日期:2004-06-01 00:00:00

  • Noninvasive three-dimensional computed tomographic angiography in preoperative detection of intracranial arteriovenous malformations.

    abstract:OBJECTIVE:To assess the value of noninvasive three-dimensional computed tomographic angiography (3D-CTA) in preoperative detection of intracranial arteriovenous malformations (AVMs). METHODS:A prospective evaluation at a single institute over a 2-year period included 23 patients suspected of intracranial AVMs. All pat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wu J,Chen X,Shi Y,Chen S

    更新日期:2000-10-01 00:00:00

  • Secreted modular calcium-binding proteins in pathophysiological processes and embryonic development.

    abstract:OBJECTIVE:Secreted modular calcium-binding proteins (SMOCs) are extracellular glycoproteins of the secreted protein, acidic, and rich in cysteine-related modular calcium-binding protein family and include two isoforms, SMOC1 and SMOC2, in humans. Functionally, SMOCs bind to calcium for various cell functions. In this r...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000472

    authors: Gao Q,Mok HP,Zhuang J

    更新日期:2019-10-20 00:00:00

  • Montelukast improves air trapping, not airway remodeling, in patients with moderate-to-severe asthma: a pilot study.

    abstract:BACKGROUND:Evidence has demonstrated that the distal lung, which includes airways of < 2 mm in diameter and lung parenchyma, constitutes an important component of asthma pathology. Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators and bronchoconstrictors involved in the asthmatic process. Guidelines ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Gao JM,Cai F,Peng M,Ma Y,Wang B

    更新日期:2013-06-01 00:00:00

  • Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are highly conserved small non-coding RNAs of 18 - 25 nucleotides (nt) that mediate post-transcriptional gene regulation. Hepatitis B virus (HBV) can cause either acute or chronic hepatitis B, and is a high risk factor for liver cirrhosis and hepatocellular carcinoma. Some mammalian viruse...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.3901/jme.2009.11.010

    authors: Liu Y,Zhao JJ,Wang CM,Li MY,Han P,Wang L,Cheng YQ,Zoulim F,Ma X,Xu DP

    更新日期:2009-01-05 00:00:00

  • Effect of antimicrobial agents on the toll-like receptors and inflammatory cytokines in liver tissue of the alcohol-induced liver disease in rats with Vibrio vulnificus sepsis.

    abstract:BACKGROUND:Septicemia and inflammation-mediated septic shock caused by Vibrio vulnificus (VV) is strongly associated with chronic liver disease. This study examined the effects of antimicrobial therapy on expression of hepatic toll-like receptors and inflammatory cytokines in rats with alcohol-induced liver disease com...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lu ZQ,Li MF,Qiu QM,Liang H,Zhou TL,Hong GL,Wu B

    更新日期:2009-08-20 00:00:00

  • Icariin associated with exercise therapy is an effective treatment for postmenopausal osteoporosis.

    abstract:BACKGROUND:There are no conclusive studies evaluating the interaction between icariin and exercise for treatment of osteoporosis; the efficacy and safety of this treatment combination remains to be evaluated. The purpose of this study was to investigate the effects of icariin treatment combined with exercise therapy on...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu M,Zhong C,He RX,Chen LF

    更新日期:2012-05-01 00:00:00

  • Preliminary results of combined carotid endarterectomy and off-pump coronary artery bypass grafting in patients with coexistent carotid and coronary artery diseases.

    abstract:BACKGROUND:Coexistent carotid and coronary artery diseases are common and patients with them remain at a high risk for perioperative stroke or myocardial infarction after coronary bypass surgery. The aim of this study was to investigate the effect of combined carotid endarterectomy (CEA) and off-pump coronary artery by...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen XJ,Chen X,Xie DH,Shi KH,Xu M

    更新日期:2009-12-20 00:00:00

  • Therapeutic antitumor response to cervical cancer in mice immunized with U14 vaccines transfected with costimulatory B7 gene.

    abstract:OBJECTIVE:To investigate the effect of U14 vaccine transfected with the B7 gene in inducing antitumor immune response to murine cervical carcinoma in Chinese 615-strain mice. METHODS:A recombinant retroviral plasmid vector expressing mouse B7-1 gene (pLNSX-mB7) was transfected into 615-strain mouse cervical carcinoma ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tao G,Hu J,Zou H,Lin Q,Liu F,Wu Y,Sun Q

    更新日期:2001-06-01 00:00:00

  • Establishment of a Rabbit Model of Chronic Obstructive Sleep Apnea and Application in Cardiovascular Consequences.

    abstract:BACKGROUND:Although obstructive sleep apnea (OSA) has been recognized as a major risk factor for cardiovascular complications and its clinical features are well characterized, it is difficult to replicate the OSA hypoxic model in humans. We aimed to establish an experimental rabbit model for chronic OSA and to explore ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.199828

    authors: Xu LF,Zhou XF,Hu K,Tang S,Luo YC,Lu W

    更新日期:2017-02-20 00:00:00

  • Epigallocatechin-3-gallate Modulates MicroRNA Expression Profiles in Human Nasopharyngeal Carcinoma CNE2 Cells.

    abstract:BACKGROUND:Epigallocatechin-3-gallate (EGCG) has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma (NPC), but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the e...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.196586

    authors: Li BB,Huang GL,Li HH,Kong X,He ZW

    更新日期:2017-01-05 00:00:00

  • Antimicrobial resistance and molecular epidemiological characteristics of clinical isolates of Staphylococcus aureus in Changsha area.

    abstract:BACKGROUND:Increasing prevalence of Staphylococcus aureus (S. aureus), particularly methicillin-resistant S. aureus (MRSA) has been reported in China. In this study, we investigated the drug resistance characteristic, genetic background, and molecular epidemiological characteristic of S. aureus in Changsha. METHODS:Be...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zou MX,Zhou RR,Wu WJ,Zhang NJ,Liu WE,Hu FP,Fan XG

    更新日期:2012-07-01 00:00:00

  • Management of cerebral ischemia due to Takayasu's arteritis.

    abstract:OBJECTIVE:To explore the management of cerebral ischemia caused by Takayasu's arteritis. METHODS:Ninety-three cases treated from June 1984 to September 1999 at the General Post & Telecom Hospital, the Sir Run Run Shaw Hospital, the First Affiliated Hospital of Zhejiang University, the Second Medical College of Beijing...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang Z,Shen L,Yu J,Gu Y,Wang S,Guan H,Wu Q,Zhang X,Li M,Wu J,Li G,Pan S,Zhang H,Jin W

    更新日期:2002-03-01 00:00:00

  • Changes of nitric oxide synthase and cyclic guanosine mono-phosphate in form deprivation myopia in guinea pigs.

    abstract:BACKGROUND:The form deprivation (FD) reduces spatial contrasts and induces myopia. Nitric oxide and cyclic guanosine monophosphate (cGMP) are involved in visual signal transmission. This study investigated changes in nitric oxide synthase (NOS) activity and cGMP concentration in ocular tissues in acute and chronic form...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wu J,Liu Q,Yang X,Yang H,Wang XM,Zeng JW

    更新日期:2007-12-20 00:00:00

  • Up-regulation of Ras/Raf/ERK1/2 signaling in the spinal cord impairs neural cell migration, neurogenesis, synapse formation, and dendritic spine development.

    abstract:BACKGROUND:The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Cao FJ,Zhang X,Liu T,Li XW,Malik M,Feng SQ

    更新日期:2013-10-01 00:00:00

  • Annular pancreas. Etiology, classification and diagnostic imaging.

    abstract::A rare type of annular pancreas, in which the tail of the annular duct is fused with the dorsal pancreatic duct to form the main duct, and its diagnostic imagings of endoscopic retrograde cholangiopancreatography, hypotonic duodenography, computed tomography and ultrasound are described. Annular pancreas is an anomaly...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lin SZ

    更新日期:1989-05-01 00:00:00

  • Vitamin D and calcium metabolism in children with nephrotic syndrome of normal renal function.

    abstract::This study demonstrates that there are distinct abnormalities of vitamin D and calcium metabolism in children with nephrotic syndrome (NS) and normal renal function. In patients with active NS, serum calcium, ionized calcium, 25-OHD3 and CT were decreased, plasma PTH level was increased and serum ALP was elevated. The...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Huang JP,Bai KM,Wang BL

    更新日期:1992-10-01 00:00:00

  • Studies on function of Hb Jianghua [beta 120 (GH3) Lys----Ile].

    abstract::Hemoglobin Jianghua (Hb Jianghua) is a new fast--moving hemoglobin variant found in China, being named after the county where it was detected. Having its primary structure analysed, we report in this paper the results of studies on its function. The absorption spectrum, response to allosteric effectors and oxygen equi...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lu YQ,Huang CH,Hu HL,Huang PY

    更新日期:1990-01-01 00:00:00

  • Iron chelator daphnetin against Pneumocystis carinii in vitro.

    abstract:BACKGROUND:Although there are several drugs and drug combinations for the treatment of Pneumocystis carinii (P. carinii) pneumonia, all drugs have the toxicity as well as low efficacy. Iron chelators have been proposed as a source of new drugs for combating these infections. We hypothesized that iron chelators would su...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ye B,Zheng YQ,Wu WH,Zhang J

    更新日期:2004-11-01 00:00:00