Abstract:
:Four calcium channel blockers, i.e. nifedipine, verapamil, cinnarizine and tetrandrine are currently available and used widely in treating cardiovascular diseases. To confirm the effects, if any, of calcium channel blockers on cirrhotic patients with portal hypertension, a study was performed on esophageal variceal pressure and rebleeding rate of esophageal varices after 2 years by using calcium channel blocker in 321 patients from some 23 hospitals. The results demonstrated that the calcium channel blockers could significantly reduce the esophageal variceal pressure and the portal blood flow in cirrhotic patients with portal hypertension. The proportion of patients with no recurrent gastrointestinal bleeding after 2 years medication of tetrandrine was 87.9% in tetrandrine group, significantly higher than those in the other 4 groups (P < 0.05). It is suggested that tetrandrine should be more effective for cirrhotic patients with portal hypertension in preventing recurrent variceal bleeding.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Li D,Lu H,Li X,Quan Q,Li X,Lu Wsubject
Has Abstractpub_date
1995-11-01 00:00:00pages
803-8issue
11eissn
0366-6999issn
2542-5641journal_volume
108pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Airway mucus hypersecretion is an important pathophysiological feature of chronic obstructive pulmonary disease, which is closely associated with cigarette smoking. However, the signal transduction pathway from the cell surface to the nucleus through which cigarette smoke causes upregulation of mucin gene ex...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
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pub_type: 杂志文章
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journal_title:Chinese medical journal
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journal_title:Chinese medical journal
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Chinese medical journal
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更新日期:2007-01-05 00:00:00
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更新日期:2007-07-05 00:00:00
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journal_title:Chinese medical journal
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doi:
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更新日期:2011-01-01 00:00:00
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更新日期:2011-09-01 00:00:00
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更新日期:2011-02-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2012-05-01 00:00:00
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journal_title:Chinese medical journal
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更新日期:1990-12-01 00:00:00
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journal_title:Chinese medical journal
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