Abstract:
BACKGROUND:Evidence has demonstrated that the distal lung, which includes airways of < 2 mm in diameter and lung parenchyma, constitutes an important component of asthma pathology. Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators and bronchoconstrictors involved in the asthmatic process. Guidelines recommend the leukotriene-modifying agents for asthma treatment. We hypothesized that a leukotriene receptor antagonist with an inhaled corticosteroid (ICS) and long-acting β2 agonist (LABA) combination would improve small airways function in moderate-to- severe asthmatics evaluated by physiological tests and high-resolution computed tomography (HRCT) analysis. This study was performed at a tertiary university hospital in Beijing. METHODS:This was a randomized, double-blind, parallel study performed in 38 patients with moderate-to-severe asthma treated with salmeterol/futicasone (SFC) plus montelukast (SFC+M) or SFC plus placebo over 24 weeks. Small airway function was assessed by physiological studies and HRCT image analysis. RESULTS:Montelukast significantly improved air trapping as expressed by the residual volume (RV)/total lung capacity (TLC). Over 24 weeks of treatment, RV/TLC was improved by (15.41 ± 6.67)% in patients receiving SFC+M while RV/TLC was decreased by (8.57 ± 10.26)% in patients receiving SFC alone, the difference between the two groups was significant (P = 0.02). There was a trend towards a significant difference in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) in the SFC+M group compared to that in the SFC group ((17.87 ± 8.17)% vs. (12.28 ± 9.20)%, P = 0.056). There was no significant change in percentage wall area (WA%) after 24 weeks of add-on treatment with montelukast. Patients receiving SFC+M showed significant improvement in the ratio of CT-determined values at full expiration to those at full inspiration (E/I ratio) (0.894 ± 0.005 vs. 0.871 ± 0.003, P = 0.002). CONCLUSION:We have shown, using lung function tests and HRCT image technique, that add-on therapy with montelukast improves distal lung function reflected by air trapping, but not airway wall thickness in moderate-to-severe asthma.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Gao JM,Cai F,Peng M,Ma Y,Wang Bsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
2229-34issue
12eissn
0366-6999issn
2542-5641journal_volume
126pub_type
杂志文章,随机对照试验abstract:BACKGROUND:One of the reasons for poor neuroregeneration after central nervous system injury is the presence of inhibitory factors such as Nogo. Here, we tested the inhibition of Nogo by RNA interference both in vitro and in vivo, using recombinant adenovirus-mediated transfection of short hairpin RNAs, to explore a ne...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The management strategies after acute myocardial infarction (AMI) have been evolving from simple supportive treatment to various protocols of thrombolytic therapies, and then to mechanical revascularization by balloon angioplasty in recent years. However, controversies still exist between which is the best tr...
journal_title:Chinese medical journal
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更新日期:1997-06-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2012-08-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
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更新日期:2000-02-01 00:00:00
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更新日期:2002-01-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
pub_type: 杂志文章,评审
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更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of red orpiment on cell morphology, expression of promyelocytic leukemia (PML) mRNA and its protein localization in NB4 and HL-60 cell lines. METHODS:Cell morphology was assayed by Wright's staining and fluorescence staining, while PML mRNA expression was determined by RT-PCR. PML ...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-01-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2008-09-05 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2013-08-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:10.1097/CM9.0000000000001177
更新日期:2020-10-06 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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更新日期:2016-06-05 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,随机对照试验
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