当前位置： SCI文献检索 > CHINESE MEDICAL JOURNAL期刊下所有文献 > Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis.

Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis.

Abstract：

BACKGROUND:Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there is need for new treatment regimens. In this study, we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis. METHODS:This study was a 52-week, multicentre, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 trial. A sub-population of study participants (≥18 years) of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab, or placebo. The co-primary endpoints were psoriasis area severity index (PASI) 75 and Investigator's Global Assessment (IGA) 0/1 at Week 12. RESULTS:A total of 441 Chinese patients were enrolled in this study. Co-primary outcomes were achieved; 300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75 (97.7% and 87.2% vs. 3.7%, respectively; P < 0.001), and IGA 0/1 (82.3% and 69.7% vs. 2.7%; P < 0.001) at Week 12. Treatment efficacy was maintained until Week 52. There was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week period. CONCLUSION:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis. TRIAL REGISTRATION:ClinicalTrials.gov, NCT03066609; https://clinicaltrials.gov/ct2/show/record/NCT03066609.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Cai L,Zhang JZ,Yao X,Gu J,Liu QZ,Zheng M,Zhang SF,Xu JH,Li CX,Cheng H,Guo Q,Pan WL,Li SQ,Li RY,Guo ZP,Song ZQ,Li SS,Dong XQ,Wang L,Fu R,Regnault P,Charef P,Mazur R,Patekar M

doi

10.1097/CM9.0000000000001163

subject

Has Abstract

pub_date

2020-11-20 00:00:00

pages

2665-2673

issue

22

eissn

0366-6999

issn

2542-5641

pii

00029330-202011200-00005

journal_volume

133

pub_type

杂志文章

相关文献

CHINESE MEDICAL JOURNAL文献大全
  • Common variants in PERK, JNK, BIP and XBP1 genes are associated with the risk of prediabetes or diabetes-related phenotypes in a Chinese population.

    abstract：BACKGROUND:Prediabetes is an early stage of β-cell dysfunction presenting as insulin resistance. Evidences suggest that endoplasmic reticulum (ER) stress is involved in the pathogenesis of type 2 diabetes mellitus and prediabetes. In a Chinese population with prediabetes, we investigated single nucleotide polymorphisms...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Feng N,Ma X,Wei X,Zhang J,Dong A,Jin M,Zhang H,Guo X

    更新日期：2014-01-01 00:00:00

  • Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model.

    abstract：BACKGROUND:Glaucoma can cause progressive damage to retinal ganglion cells. These cells can be classified as cells projecting to the superior colliculus and melanopsin-containing retinal ganglion cells, which project to the suprachiasmatic nucleus. This study was to investigate the effects of chronic intraocular pressu...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Wang HZ,Lu QJ,Wang NL,Liu H,Zhang L,Zhan GL

    更新日期：2008-06-05 00:00:00

  • Association of interleukin-6 promoter polymorphism with knee osteoarthritis: a meta-analysis.

    abstract：BACKGROUND:Osteoarthritis (OA) is the most common form of human polyarthritis. Many genetic factors have been implicated in OA. It was reported that a polymorphism in the gene of interleukin-6 (IL-6) was associated with OA of knee. The aim of this study was to determine whether functional IL-6 promoter -174G/C (rs18007...

    journal_title：Chinese medical journal

    pub_type： 杂志文章,meta分析

    doi：

    authors： Ai Z,Ning X,Shou T,Tang W,Luo Y,Zhang J

    更新日期：2014-01-01 00:00:00

  • Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome.

    abstract：BACKGROUND:Irritable bowel syndrome (IBS) is reported associated with the alteration of gut microbial composition termed as dysbiosis. However, the pathogenic mechanism of IBS remains unclear, while the studies of Chinese individuals are scarce. This study aimed to understand the concept of dysbiosis among patients wit...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：10.1097/CM9.0000000000000192

    authors： Wang Z,Xu CM,Liu YX,Wang XQ,Zhang L,Li M,Zhu SW,Xie ZJ,Wang PH,Duan LP,Zhu HQ

    更新日期：2019-04-20 00:00:00

  • Blood hibernation: a novel strategy to inhibit systemic inflammation and coagulation induced by cardiopulmonary bypass.

    abstract：BACKGROUND:Inflammation and coagulation are two intimately cross-linked defense mechanisms of most, if not all organisms to injuries. During cardiopulmonary bypass (CPB), these two processes are activated and interact with each other through several common pathways, which may result in subsequent organ dysfunction. In ...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhou J,Wu XD,Lin K,Lui RC,An Q,Tao KY,Du L,Liu J

    更新日期：2010-07-01 00:00:00

  • Correlation of Betel Quid with Oral Cancer from 1998 to 2017: A Study Based on Bibliometric Analysis.

    abstract：Background:Betel quid chewing has been a major risk factor for oral cancer (OC) in southern China. This study aimed to analyze the scientific publications on the relationship between betel quid chewing and OC and construct a model to quantitatively and qualitatively evaluate pertinent publications from 1998 to 2017. M...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：10.4103/0366-6999.238140

    authors： Wang M,Xiao C,Ni P,Yu JJ,Wang XW,Sun H

    更新日期：2018-08-20 00:00:00

  • Apolipoprotein (a) phenotypes in cardio-cerebrovascular diseases.

    abstract：:Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhuang YY,Li JJ,Wang JJ

    更新日期：1994-02-01 00:00:00

  • Bioactive proteins in healthy pregnancies and preeclampsia: relevance to hypertension and proteinuria.

    abstract：BACKGROUND:Bioactive proteins, such as cytokines and chemokines, have not been systematically evaluated in healthy and preeclamptic pregnancies. We aimed to investigate the difference of these proteins between healthy and preeclamptic pregnancies in order to help clarify their potential roles in the pathogenesis of hyp...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Wang T,Wang YY,Zhou R,Song CP,Lin W,Niu XY,Zhang L,Hu HZ

    更新日期：2013-01-01 00:00:00

  • Propofol improves cardiac functional recovery after ischemia-reperfusion by upregulating nitric oxide synthase activity in the isolated rat hearts.

    abstract：BACKGROUND:There are few studies to assess whether propofol attenuates myocardial ischemia-reperfusion injury via a mechanism related to nitric oxide (NO) route, so we designed this randomized blinded experiment to observe the changes of NO contents, nitric oxide synthase (NOS) activity, NOS contents in the myocardium,...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Sun HY,Xue FS,Xu YC,Li CW,Xiong J,Liao X,Zhang YM

    更新日期：2009-12-20 00:00:00

  • Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease.

    abstract：OBJECTIVE:The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD). DATA SOURCES:Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between January 1988 and November 2016 were searched using the following k...

    journal_title：Chinese medical journal

    pub_type： 杂志文章,评审

    doi：10.4103/0366-6999.211555

    authors： Du JJ,Chen SD

    更新日期：2017-08-05 00:00:00

  • Microarray analysis of extracellular matrix genes expression in myocardium of mouse with Coxsackie virus B3 myocarditis.

    abstract：BACKGROUND:Extracellular matrix (ECM) orchestrates cell behaviour including growth, death, apoptosis, adhesion, migration, and invasion by activating several signalling pathways. Certain components of ECM, such as integrins, may act as receptors or co-receptors of enterovirus. ECM-activated gene expressions in myocardi...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhang ZC,Li SJ,Yang YZ,Chen RZ,Ge JB,Chen HZ

    更新日期：2004-08-01 00:00:00

  • Intracoronary stent implantation under intracoronary ultrasound guidance with aspirin and ticlopidine therapy.

    abstract：OBJECTIVE:To observe the immediate angiographic and intravascular ultrasound (IVUS) results and their effects on one month clinical outcomes in forty-one patients who submitted to coronary stent deployment with IVUS guidance. METHODS:All patients were allocated to coronary stent implantation with high inflation pressu...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhang D,Cai X,Shen W,Schiele F,Bassand JP

    更新日期：2001-03-01 00:00:00

  • Combined use of extended-release niacin and atorvastatin: safety and effects on lipid modification.

    abstract：BACKGROUND:Cholesterol-lowering therapy with statins has been reported to reduce the morbidity and mortality of cardiovascular diseases. This study aimed to investigate the effects of combined application of extended-release niacin and atorvastatin on lipid profile modification and the risks of adverse events in patien...

    journal_title：Chinese medical journal

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Sang ZC,Wang F,Zhou Q,Li YH,Li YG,Wang HP,Chen SY

    更新日期：2009-07-20 00:00:00

  • Changes of serial cerebrospinal fluid immunoglobulin parameters in neurological disorders.

    abstract：:Serial cerebrospinal fluid immunoglobulin parameters were determined with the method of single radial immunodiffusion in 419 cases of 20 kinds of neurological diseases. The results were compared with the normal values of 36 subjects of corresponding ages and statistically analyzed. The authors believe that the elevate...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Wang WZ,Zhou YK

    更新日期：1989-03-01 00:00:00

  • Vitamin D and calcium metabolism in children with nephrotic syndrome of normal renal function.

    abstract：:This study demonstrates that there are distinct abnormalities of vitamin D and calcium metabolism in children with nephrotic syndrome (NS) and normal renal function. In patients with active NS, serum calcium, ionized calcium, 25-OHD3 and CT were decreased, plasma PTH level was increased and serum ALP was elevated. The...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Huang JP,Bai KM,Wang BL

    更新日期：1992-10-01 00:00:00

  • Aminoglycoside ototoxicity in three murine strains and effects on NKCC1 of stria vascularis.

    abstract：BACKGROUND:After establishing a murine model of aminoglycoside antibiotic (AmAn) induced ototoxicity, the sensitivity of AmAn induced ototoxicity in three murine strains and the effect of kanamycin on the expression of Na-K-2Cl cotransporter-1 (NKCC1) in stria vascularis were investigated. METHODS:C57BL/6J, CBA/CaJ, N...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Chu HQ,Xiong H,Zhou XQ,Han F,Wu ZG,Zhang P,Huang XW,Cui YH

    更新日期：2006-06-20 00:00:00

  • Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis.

    abstract：OBJECTIVE:Sepsis remains a leading cause of death in many Intensive Care Units worldwide. Immunosuppression has been a primary focus of sepsis research as a key pathophysiological mechanism. Given the important role of the negative costimulatory molecules programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD...

    journal_title：Chinese medical journal

    pub_type： 杂志文章,评审

    doi：10.4103/0366-6999.204113

    authors： Liu Q,Li CS

    更新日期：2017-04-20 00:00:00

  • Efficacy and safety of a novel nano-porous polymer-free sirolimus-eluting stent in pigs.

    abstract：BACKGROUND:Drug-eluting stents represent a major advance in interventional cardiology. However, the current drug-eluting stents have significant limitations. One of the major problems is very late stent thrombosis, which is likely caused by inflammation and a hypersensitivity reaction related to a polymer on the stent....

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Chen M,Zheng B,Wu Z,Peng HY,Wang XG,Zhang B,Huo Y

    更新日期：2013-01-01 00:00:00

  • Outcome and risk factors of early onset severe preeclampsia.

    abstract：BACKGROUND:Early onset severe preeclampsia is a specific type of severe preeclampsia, which causes high morbidity and mortality of both mothers and fetus. This study aimed to investigate the clinical definition, features, treatment, outcome and risk factors of early onset severe preeclampsia in Chinese women. METHODS:...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Gong YH,Jia J,Lü DH,Dai L,Bai Y,Zhou R

    更新日期：2012-07-01 00:00:00

  • Management of cerebral ischemia due to Takayasu's arteritis.

    abstract：OBJECTIVE:To explore the management of cerebral ischemia caused by Takayasu's arteritis. METHODS:Ninety-three cases treated from June 1984 to September 1999 at the General Post & Telecom Hospital, the Sir Run Run Shaw Hospital, the First Affiliated Hospital of Zhejiang University, the Second Medical College of Beijing...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Wang Z,Shen L,Yu J,Gu Y,Wang S,Guan H,Wu Q,Zhang X,Li M,Wu J,Li G,Pan S,Zhang H,Jin W

    更新日期：2002-03-01 00:00:00

  • Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients.

    abstract：BACKGROUND:Diabetes mellitus plays an important role in cancer prevalence and outcomes. The aim of this study was to evaluate the influence of DM on stages and outcomes among patients with colorectal cancer. METHODS:The study enrolled 945 patients who were diagnosed as having colorectal carcinoma from August 1994 to D...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Chen CQ,Fang LK,Cai SR,Ma JP,Yang GX,Yang W,Zhan WH,He YL

    更新日期：2010-11-01 00:00:00

  • Root avulsion of brachial plexus in infants and children.

    abstract：:Twenty-one patients, under 6 years of age, with root avulsion of the brachial plexus were treated from 1975 to 1987. Among them, 9 had root avulsion of the upper trunk, 2 root avulsion of the lower trunk with middle trunk broken, and 10 root avulsion of the whole brachial plexus. Follow-up of 16 patients showed excell...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhang GM,Gu YD,Chen DS,Yan JG,Cheng XM

    更新日期：1990-05-01 00:00:00

  • Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer.

    abstract：BACKGROUND:It has been confirmed that defective expression of human leukocyte antigen class I (HLA-I) molecules can contribute to the immune evasion of cancer cells in some types of cancer. The aim of this study was to examine the expression of HLA class I antigen and the antigen-processing machinery (APM) components i...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Ayshamgul H,Ma H,Ilyar S,Zhang LW,Abulizi A

    更新日期：2011-02-01 00:00:00

  • Clinical Analysis of Postpartum Hemorrhage Requiring Massive Transfusions at a Tertiary Center.

    abstract：BACKGROUND:The reports on massive transfusions (MTs) in obstetrics have recently been an increasing trend. We aimed to define the clinical features, risk factors, main causes, and outcomes of MTs due to severe postpartum hemorrhage (PPH) and the frequency trends over the past 10 years. METHODS:We retrospectively analy...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：10.4103/0366-6999.200545

    authors： Hu J,Yu ZP,Wang P,Shi CY,Yang HX

    更新日期：2017-03-05 00:00:00

  • Laparoscopic Heller-Dor operation for patients with achalasia.

    abstract：BACKGROUND:Laparoscopic Heller cardiomyotomy and Dor fundoplication is the surgical procedure of choice for esophageal achalasia. The aim of this study was to investigate the clinical outcome of laparoscopic Heller-Dor procedure in our initial series of 25 patients with achalasia. METHODS:Between October 2003 and Janu...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Wang QS,Liu L,Dong L,Shen ZL,Zhou DH,Hu CX

    更新日期：2006-03-20 00:00:00

  • Radical treatment strategies improve the long-term outcome of recurrent atypical meningiomas.

    abstract：BACKGROUND:Atypical meningioma is one of the rare subtypes of meningioma, which is lacking of optimal consensus on treatment strategies. This study aimed to investigate the radical treatment strategies to improve the long-term outcome of recurrent atypical meningiomas. METHODS:The prognostic factors including the age ...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Li F,Lai ZP,Lin JK,Zhu G,Feng H

    更新日期：2011-08-01 00:00:00

  • Predictors to assess non-sentinel lymph node status in breast cancer patients with only one sentinel lymph node metastasis.

    abstract：BACKGROUND:The purpose of this study was to investigate the feasibility of avoiding axillary lymph node dissection (ALND) for patients with only one sentinel lymph node (SLN) metastasis. The characteristics and predictive factors for non-sentinel lymph node (NSLN) metastasis of patients with single positive SLN were al...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Yang B,Yang L,Zuo WS,Ge WK,Zheng G,Zheng MZ,Yu ZY,Wang YS

    更新日期：2013-02-01 00:00:00

  • Treatment of platinum-resistant recurrent ovarian cancer using a "predictive molecule targeted routine chemotherapy" system.

    abstract：BACKGROUND:Correct drug selection, the key to successful chemotherapy, is one of the most difficult clinical decisions for the treatment of platinum-resistant recurrent ovarian cancer worldwide. The exact procedures for choosing drugs are undefined, currently relying on clinical trials and personal experience, which of...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhao XD,Wei FH,Zhang Y,He SR,Yang L

    更新日期：2009-12-05 00:00:00

  • Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract.

    abstract：OBJECTIVE:To study the clinicopathologic features and immunoprofile of angiomyofibroblastoma (AMF) with emphasis on differential diagnosis. METHODS:Seven vulvar, two vaginal and one perineal angiomyofibroblastomas were evaluated by light microscopy and immunohistochemistry. The immunohistochemical studies were perform...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Wang J,Sheng W,Tu X,Shi D,Zhu X,Zhang R

    更新日期：2000-11-01 00:00:00

  • Effect of endothelial PAS domain protein 1 and hypoxia inducible factor 1alpha on vascular endothelial growth factor expression in human pancreatic carcinoma.

    abstract：BACKGROUND:Transcription factors hypoxia inducible factor 1alpha (HIF 1alpha) and endothelial PAS domain protein 1 (EPAS1) promote the transcription of vascular endothelial growth factor (VEGF). VEGF enhances angiogenesis and vascular permeability of tumours, which promotes tumour growth and facilitates entry of cancer...

    journal_title：Chinese medical journal

    pub_type： 杂志文章

    doi：

    authors： Zhu DM,Li DC,Zhang ZX,Zhang XY

    更新日期：2008-11-20 00:00:00