Effects of gypenosides on cellular immunity of gamma-ray-irradiated mice.

Abstract:

OBJECTIVE:To investigate the effects of gypenosides (Gs) on cellular immunocompetence in the gamma-ray-irradiated mice. MATERIALS AND METHODS:Tested mice of ICR strain were treated continuously with Gs for 10 days before or after 4 Gy gamma-irradiation. Body weight and splenic weight of mice were measured. The blastogenic response of splenocytes to mitogens, such as PHA, Con A and LPS were also detected. The cellular immunocompetence was measured by 3H-thymidine incorporation in each tested mouse. RESULTS:Body weight as well as splenic weight decreased in gamma-ray-irradiated mice. The blastogenic responses of splenocytes to mitogens were inhibited after gamma-ray irradiation. To treat with Gs was effective to enhance the recovery of body weight, splenic weight and immunocompetence in gamma-ray-irradiated mice from radiation damage. CONCLUSIONS:Four Gy gamma-ray irradiation could decrease splenic weight and cellular immunocompetence of mice. Gs could help the recovery of the splenic weight and cellular immunocompetence in gamma-ray-irradiated mice.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Hau DM,Feng Y,Chen WC,Lin IH,Chen KT,Lin SS,Wang MI

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

143-6

issue

2

eissn

0366-6999

issn

2542-5641

journal_volume

109

pub_type

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