Antitumor activity of psoralen on mucoepidermoid carcinoma cell line MEC-1.

Abstract:

:Psoralen (PSO) was found cytotoxic against in vitro cultured human mucoepidermoid carcinoma cells of MEC-1 cell line. Its IC50 value was 8.6 micrograms/ml, and relative antitumor activity (RAA) 15. PSO suppressed DNA synthesis, damaged microvilli and cell membrane, and induced degeneration of mitochondria. It inhibited the growth of MEC-1 cells transplanted in nude mice by 79.1% which was as strong as pingyanmycin (PYM 81.4%). The body weight loss of PSO treated tumor-bearing mice was 5%, whereas that of PYM treated ones 13.3% (P < 0.01). PSO may be an effective agent for the treatment of human mucoepidermoid carcinoma.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Wu JZ,Situ ZQ,Wang W,Chen JY,Liu B

keywords:

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

913-7

issue

11

eissn

0366-6999

issn

2542-5641

journal_volume

105

pub_type

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