Pancreatic and duodenal homeobox-1 in pancreatic ductal adenocarcinoma and diabetes mellitus.

Abstract:

:Diabetes mellitus and pancreatic ductal adenocarcinoma are two common diseases worldwidely which are both derived from different components of pancreas. The pancreatic and duodenal homeobox-1 (PDX1) is an essential transcription factor for the early development of pancreas that is required for the differentiation of all pancreatic cell lineages. Current evidence suggests an important role of PDX1 in both the origin and progression of pancreatic diseases. In this review, we discussed recent studies of PDX1 in diabetes mellitus and pancreatic cancer, and the therapeutic strategies derived from this transcription factor.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Tang ZC,Chu Y,Tan YY,Li J,Gao S

doi

10.1097/CM9.0000000000000628

subject

Has Abstract

pub_date

2020-02-05 00:00:00

pages

344-350

issue

3

eissn

0366-6999

issn

2542-5641

pii

00029330-202002050-00012

journal_volume

133

pub_type

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