Early-life nutrition and metabolic disorders in later life: a new perspective on energy metabolism.

Abstract:

:Type 2 diabetes mellitus and metabolic disorders have become an epidemic globally. However, the pathogenesis remains largely unclear and the prevention and treatment are still limited. In addition to environmental factors during adulthood, early life is the critical developmental window with high tissue plasticity, which might be modified by external environmental cues. Substantial evidence has demonstrated the vital role of early-life nutrition in programming the metabolic disorders in later life. In this review, we aim to overview the concepts of fetal programming and investigate the effects of early-life nutrition on energy metabolism in later life and the potential epigenetic mechanism. The related studies published on PubMed database up to March 2020 were included. The results showed that both maternal overnutrition and undernutrition increased the riskes of metabolic disorders in offspring and epigenetic modifications, including DNA methylation, miRNAs, and histone modification, might be the vital mediators. The beneficial effects of early-life lifestyle modifications as well as dietary and nutritional interventions on these deleterious metabolic remolding were initially observed. Overall, characterizing the early-life malnutrition that reshapes metabolic disease trajectories may yield novel targets for early prevention and intervention and provide a new point of view to the energy metabolism.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Zhou LY,Deng MQ,Zhang Q,Xiao XH

doi

10.1097/CM9.0000000000000976

subject

Has Abstract

pub_date

2020-08-20 00:00:00

pages

1961-1970

issue

16

eissn

0366-6999

issn

2542-5641

pii

00029330-202008200-00010

journal_volume

133

pub_type

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