Local tissue hypoxia and formation of nasal polyps.

Abstract:

OBJECTIVE:To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP). METHODS:Epithelial cells of NP and inferior turbinate (IT) were cultured serum-free under normal oxygen and hypoxic circumstances with stimulation of IL-1 beta and TNF alpha. The vascular endothelial growth factor (VEGF) mRNA and VEGF protein levels of the cultured cells were detected using in situ hybridization and ELISA, respectively. RESULTS:The expression of VEGF mRNA was significantly higher in epithelial cells of NP than in IT exposed to pro-inflammatory cytokines or hypoxia (P < 0.01). VEGF levels were higher in NP epithelial cells than those of IT (P < 0.01) under hypoxia. CONCLUSION:VEGF-induced by hypoxia is very important for the early stages of forming polyps.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Jiang S,Dong Z,Zhu D,Yang Z

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

243-7

issue

2

eissn

0366-6999

issn

2542-5641

journal_volume

116

pub_type

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