Rapid expression of vascular endothelial growth factor in early acute myocardial ischemia in rats.

Abstract:

OBJECTIVE:To study the expression of vascular endothelial growth factor (VEGF) in different parts of heart during early acute myocardial ischemia. METHODS:The expression of VEGF in control and study group in rats was performed with the Strept Avidin-Biotin-Peroxidase Complex (SABC) method. RESULTS:A rapid expression of VEGF in ischemic areas was observed 1 hour after the ligation of rat left anterior descending (LAD) coronary artery, and in peri-ischemic and non-ischemic areas 3 hours after ischemia. The grade of expression of VEGF increased with the continuation of myocardial ischemia, the positive myocytes of SABC-VEGF staining mainly localized in peri-ischemic areas 5 hours after ischemia. No expression of VEGF in control group was found. CONCLUSION:The expression of VEGF may be up-regulated in rapid and continuous manner with characteristic spatial and temporal kinetic during early acute myocardial ischemia.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Chen J,Xu X,Wu X,Zhu J

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

758-60

issue

8

eissn

0366-6999

issn

2542-5641

journal_volume

112

pub_type

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