Effects of different vasopressors on hemodynamics in patients undergoing orthotopic liver transplantation.

Abstract:

BACKGROUND:The hyperdynamic circulatory state in end-stage liver disease is similar to the hemodynamic state in endotoxic shock. Recent research indicated that proper use of norepinephrine (NE) in patients with endotoxic shock could improve the perfusion of visceral organs and raise the survival rate. In this study, dopamine (DA) or NE combined with DA was infused during the orthotopic liver transplantation (OLT) to observe and compare their effects on hemodynamics, oxygenation, and renal function during different stages of the operation. METHODS:Thirty American Society of Anesthesiology (ASA) III-IV patients undergoing OLT were randomly divided into group DA and group NE with 15 patients in each group. Vasopressors were infused after induction of anesthesia. DA was infused in group DA; DA and NE in group NE. Data of hemodynamics, oxygenation and renal function were collected after induction, 1 hour in preanhepatic, anhepatic, neohepatic phase and at the end of operation. RESULTS:Heart rate (HR) and mean arterial pressure (MAP) of the two groups were stable. In anhepatic phase, central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), pulmonary arterial wedge pressure (PAWP), cardiac output (CO), and cardiac index (CI) decreased, whereas systemic vascular resistance (SVR) and systemic vascular resistance index (SVRI) increased significantly (P < 0.05). The hemodynamic variables of group NE were more stable than that of group DA. Pulmonary vascular resistance (PVR), pulmonary vascular resistance index (PVRI), power of hydrogen (pH), and mixed venous oxygen saturation (SvO2) had no significant changes. Oxygen delivery (DO2) and oxygen consumption (VO2) decreased during anhepatic phase (P < 0.05), but lactic acid (LAC) increased since anhepatic phase. Blood urea nitrogen (BUN) maintained relatively stable during different phases. Group NE had more urine output (F = 4.733, P = 0.039). CONCLUSIONS:During OLT, both DA and NE combined with DA can maintain hemodynamics stable, whereas the latter may create better condition. NE has positive effects on maintenance of renal function.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Zhang LP,Li M,Yang L

keywords:

subject

Has Abstract

pub_date

2005-12-05 00:00:00

pages

1952-8

issue

23

eissn

0366-6999

issn

2542-5641

journal_volume

118

pub_type

杂志文章,随机对照试验
  • A serological study of hepatitis C infection in plasmapheresis donors.

    abstract::An epidemic of parenterally transmitted non-A, non-B hepatitis (PT-NANBH) occurred in plasmapheresis donors in Guan County, Hebei Province, China, in 1985. PT-NANBH was diagnosed by epidemiological studies and serological exclusion of HAV, HBV, CMV and EBV infections. Recently, 163 sera samples of 108 patients with PT...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Meng ZD,Sun YD,Chen XR,Wang SY,Sun DG,Chen Z,Liu CB,Zhuang H,Xu ZY

    更新日期:1991-06-01 00:00:00

  • Central Nervous System Involvement in Hemophagocytic Lymphohistiocytosis in Adults: A Retrospective Analysis of 96 Patients in a Single Center.

    abstract:Background:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement is a severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out this ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.228234

    authors: Song Y,Pei RJ,Wang YN,Zhang J,Wang Z

    更新日期:2018-04-05 00:00:00

  • Effects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes mellitus.

    abstract:BACKGROUND:A five-year follow-up study of intensive multifactorial intervention was undertaken to assess the changes of circulating serum amyloid A (SAA) levels and the incidence of atherosclerosis (AS) in patients with short-duration type 2 diabetes mellitus (T2DM) without macroangiopathy, and whether intensive multif...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Du JL,Liu JF,Men LL,Yao JJ,Sun LP,Sun GH,Song GR,Yang Y,Bai R,Xing Q,Li CC,Sun CK

    更新日期:2009-11-05 00:00:00

  • Enzyme-linked immunosorbent assay for detection of immunoglobulin G antibody against Helicobacter pylori.

    abstract::Eight strains of sonicated Helicobacter pylori (H. pylori) were pooled as group antigen to detect the serum IgG antibody to H. pylori in patients with various gastroduodenal diseases and subjects at health check-up. The enzyme-linked immunosorbent assay method used had a sensitivity of 94%, a specificity of 87%, and a...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xiao SD,Pan ZJ,Zhang ZH,Jiang SJ

    更新日期:1991-11-01 00:00:00

  • Cardiovascular events in hyperuricemia population and a cardiovascular benefit-risk assessment of urate-lowering therapies: a systematic review and meta-analysis.

    abstract:BACKGROUND:Hyperuricemia and gout have become public health concerns; many important guidelines have recommended xanthine oxidase inhibitors (XOIs) as the first-line urate-lowering therapies (ULTs) to treat chronic gout with hyperuricemia. However, whether treating hyperuricemia and gout with ULTs modifies cardiovascul...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,meta分析

    doi:10.1097/CM9.0000000000000682

    authors: Zhao L,Cao L,Zhao TY,Yang X,Zhu XX,Zou HJ,Wan WG,Xue Y

    更新日期:2020-04-20 00:00:00

  • Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer's ring non-Hodgkin lymphoma.

    abstract:OBJECTIVE:To improve the prognosis and therapeutic efficacy of Waldeyer's ring non-Hodgkin lymphoma (NHL-WR), combined radio-chemotherapy was used to treat the patients with NHL-WR and prognostic factors were analyzed. METHODS:Ninety patients with stage I-IV NHL-WR were treated with combined radio-chemotherapy. 4000 c...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yong W,Zhang Y,Zheng W,Wei Y

    更新日期:2000-02-01 00:00:00

  • Impact of multidisciplinary team working on the management of colorectal cancer.

    abstract:BACKGROUND:The continual and rapid development of techniques which are used for diagnosis and treatment makes management of colorectal cancer more difficult depending on single discipline. Colorectal cancer multidisciplinary team (MDT) working model is recommended by UK and other countries, but there is little informat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ye YJ,Shen ZL,Sun XT,Wang ZF,Shen DH,Liu HJ,Zhang WL,Chen YL,Zhou J,Poston GJ,Wang S

    更新日期:2012-01-01 00:00:00

  • A randomized control trial on interruption of HBV transmission in uterus.

    abstract:OBJECTIVE:To study the interruptive effect of hepatitis B virus (HBV) specific immunolobulin (HBIG) before delivery in attempt to prevent intrauterine transmission of HBV. METHODS:Nine hundred and eighty HBsAg carrier pregnant women were randomly divided into HBIG group and control group. Each subject in the HBIG grou...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Zhu Q,Yu G,Yu H,Lu Q,Gu X,Dong Z,Zhang X

    更新日期:2003-05-01 00:00:00

  • Lectin histochemistry in psoriasis, lichen planus and seborrheic keratosis.

    abstract::Lectin binding patterns in psoriasis, lichen planus and seborrheic keratosis lesions were studied using 14 different biotinyl lectins and avidin-horseradish peroxidase. Compared with normal epidermis, there were significant quantitative and qualitative differences, some of which were characteristic. ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Gao MY,Lin XR,Miao Q

    更新日期:1992-12-01 00:00:00

  • Aortic arch and intra-/extracranial cerebral arterial atherosclerosis in patients suffering acute ischemic strokes.

    abstract:OBJECTIVE:To determine the distribution of aortic arch and intra/extracranial cerebral arterial atherosclerosis in Chinese patients who had suffered acute ischemic strokes. METHODS:Eighty-nine patients with acute ischemic strokes were included in this study. Transesophageal echocardiography (TEE) was used to evaluate ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Guo Y,Jiang X,Chen S,Zhang S,Zhao H,Wu Y

    更新日期:2003-12-01 00:00:00

  • Effects of decline in renal function with age on the outcome of asymptomatic carotid plaque in healthy adults: a 5-year follow-up study.

    abstract:BACKGROUND:It has been long suggested that abnormal clinical factors in the body, such as dyslipidemia and diabetes, can affect the presence of atherosclerosis. However, few studies on the effect of factors within the normal range, such as the loss of renal function with age, on the prevalence of atherosclerosis are fe...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Jiang SM,Sun XF,Gu HX,Chen YS,Xi CS,Qiao X,Chen XM

    更新日期:2012-08-01 00:00:00

  • Endovenous laser ablation of great saphenous vein with ultrasound-guided perivenous tumescence: early and midterm results.

    abstract:BACKGROUND:Endovenous laser ablation (EVLA) is an improved method to treat varicose great saphenous veins (GSV) with a high satisfactory rate. This study aimed to evaluate the efficiency and safety of treatment by EVLA procedures with ultrasound-guided perivenous tumescence. METHODS:Thirty-one patients (31 limbs) with...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen JQ,Xie H,Deng HY,Yuan K,Zhang JW,Zhang H,Zhang L

    更新日期:2013-02-01 00:00:00

  • Blocking Posttranslational Core Fucosylation Ameliorates Rat Peritoneal Mesothelial Cell Epithelial-Mesenchymal Transition.

    abstract:Background::Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor (TGF)-β receptors and platelet-derived growth factor (PDGF) recep...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.213963

    authors: Li LK,Wang N,Wang WD,Du XN,Wen XY,Wang LY,Deng YY,Wang DP,Lin HL

    更新日期:2017-09-20 00:00:00

  • Phosphoproteomics Analysis of Endometrium in Women with or without Endometriosis.

    abstract:BACKGROUND:The molecular mechanisms underlying the endometriosis are still not completely understood. In order to test the hypothesis that the approaches in phosphoproteomics might contribute to the identification of key biomarkers to assess disease pathogenesis and drug targets, we carried out a phosphoproteomics anal...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.166022

    authors: Xu HM,Deng HT,Liu CD,Chen YL,Zhang ZY

    更新日期:2015-10-05 00:00:00

  • CSF-VP shunt placement and albendazole therapy for cerebral cysticercosis.

    abstract::Cerebral cysticercosis is the most common worldwide parasitic infection of the central nervous system. Intraventricular involvement is apparent in 15% to 28.8% of cases with neural compartment infestation.' Although different forms of the disease (parenchymatous, subarachnoid, and mixed form ) have been treated succes...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu L,Weng X,Shi Y,Pan X,Mo L

    更新日期:2002-06-01 00:00:00

  • Influence of lesion ratio on diagnostic performance of in-phase/opposed-phase imaging and apparent diffusion coefficient for differentiating acute benign vertebral fractures and metastases.

    abstract:BACKGROUND:The usefulness of in-phase/opposed-phase imaging and diffusion weighted imaging (DWI) in differentiating benign and neoplastic vertebral fractures has been described. In this study, we aimed to evaluate the influence of the severity of vertebral damage on the diagnostic performance of these two technologies....

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lin F,Lei Y,Li YB

    更新日期:2009-06-05 00:00:00

  • Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients.

    abstract:BACKGROUND:Recently, conservative surgery is acceptable in young patients with borderline ovarian tumor and ovarian cancer. The preservation of these patients' future fertility has been the focus of recent interest. This study aimed to observe the effect of gonadotropin-releasing hormone agonists (GnRHa) cotreatment du...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu HL,Wang Y,Li XP,Wang CH,Wang Y,Cui H,Wang JL,Wei LH

    更新日期:2013-02-01 00:00:00

  • Effect of lumbar angular motion on central canal diameter: positional MRI study in 491 cases.

    abstract:BACKGROUND:Lumbar spinal stenosis is a common problem that is receiving attention with the advent of novel treatment procedures. Prior positional MRI studies demonstrated lumbar canal diameter changes with flexion and extension. There have not been any studies to examine the amount of spinal canal diameter change relat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wei F,Wang J,Zou J,Hong SW,Zhang H,He W,Miyazaki M,Lee SH,Alanay A

    更新日期:2010-06-01 00:00:00

  • Recent approaches to His-Purkinje system pacing.

    abstract:OBJECTIVE:Physiologic cardiac pacing is a novel technique which has been largely popularized in recent decades. His bundle pacing (HBP) has been long considered the most physiologic pacing method; however, with the widespread implementation of this method, its disadvantages have become apparent. In this context, left b...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000038

    authors: Cheng LT,Zhang JM,Wang ZF,Gao HK,Wu YQ

    更新日期:2019-01-20 00:00:00

  • Role of Whole-exome Sequencing in Phenotype Classification and Clinical Treatment of Pediatric Restrictive Cardiomyopathy.

    abstract:BACKGROUND:Restrictive cardiomyopathy (RCM) is the least common cardiomyopathy in which the walls are rigid and the heart is restricted from stretching and filling properly. Cardiac troponin I (cTnI) mutation-caused myofibril Ca2+ hypersensitivity has been shown to be associated with impaired diastolic function. This s...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.219150

    authors: Ding WH,Han L,Xiao YY,Mo Y,Yang J,Wang XF,Jin M

    更新日期:2017-12-05 00:00:00

  • Role of peroxisome proliferator-activated receptor alpha activation in acute myocardial damage induced by isoproterenol in rats.

    abstract:BACKGROUND:Peroxisome proliferator-activated receptor (PPAR) alpha is one of the subtypes of PPARs. It regulates metabolism of lipid and lipoprotein, as well as glucose homeostasis. In addition, PPARalpha influences cellular proliferation, inflammation, differentiation and apoptosis, which plays a vital role in cardiov...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yuan J,Wu J,Hang ZG,Zhong XK,Zhou LW,Yu B

    更新日期:2008-08-20 00:00:00

  • Detection of 100% oxygen induced changes in retina using magnetic resonance imaging: a human study.

    abstract:BACKGROUND:Inner retinal oxygenation response (ΔPO(2)) is a worldwide study focus. However, the relevant reports on its radiological measurements are limited. In this study, magnetic resonance imaging (MRI), employing T1 weighted image (T1WI), was used to detect changes in ΔPO(2) following 100% oxygen inhalation in hum...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu QG,Chen QH,Xian JF,Wang ZC

    更新日期:2010-11-01 00:00:00

  • Nine-month angiographic and two-year clinical follow-up of novel biodegradable-polymer arsenic trioxide-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease.

    abstract:BACKGROUND:Despite great reduction of in-stent restenosis, first-generation drug-eluting stents (DESs) have increased the risk of late stent thrombosis due to delayed endothelialization. Arsenic trioxide, a natural substance that could inhibit cell proliferation and induce cell apoptosis, seems to be a promising surrog...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/0366-6999.152490

    authors: Shen L,Yang W,Yin JS,Liu XB,Wu YZ,Sun AJ,Qian JY,Ge JB

    更新日期:2015-03-20 00:00:00

  • Activation and coreceptor expression of T lymphocytes induced by highly active antiretroviral therapy in Chinese HIV/AIDS patients.

    abstract:BACKGROUND:At the end of 2005, 650,000 people lived with human immunodeficiency virus type-1 (HIV-1) in China, of whom 75 000 were AIDS patients. Many AIDS patients received highly active antiretroviral therapy (HAART) supported by the "China CARES" program but the immune responses of HAART were seldom reported. This s...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang ZN,Shang H,Jiang YJ,Liu J,Dai D,Diao YY,Geng WQ,Jin X,Wang YN

    更新日期:2006-12-05 00:00:00

  • Value of Kidney Disease Improving Global Outcomes Urine Output Criteria in Critically Ill Patients: A Secondary Analysis of a Multicenter Prospective Cohort Study.

    abstract:BACKGROUND:Urine output (UO) is an essential criterion of the Kidney Disease Improving Global Outcomes (KDIGO) definition and classification system for acute kidney injury (AKI), of which the diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria (KDIGOUO) could ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.4103/0366-6999.189059

    authors: Qin JP,Yu XY,Qian CY,Li SS,Qin TH,Chen EZ,Lin JD,Ai YH,Wu DW,Liu DX,Sun RH,Hu ZJ,Cao XY,Zhou FC,He ZY,Zhou LH,An YZ,Kang Y,Ma XC,Zhao MY,Jiang L,Xu Y,Du B,China Critical Care Clinical Trial Group (CCCCTG).

    更新日期:2016-09-05 00:00:00

  • Protective effect of O6-methylguanine-DNA-methyltransferase on mammalian cells.

    abstract:BACKGROUND:O(6)-methylguanine-DNA-methyltransferase (MGMT) is a specific DNA revising enzyme transferring alkylated groups from DNA to its cysteine residue to avoid the abnormal twisting of DNA. Therefore, it is one of the drug resistant genes targeted in the treatment of cancer. This study explored the protective effe...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li DB,Wang JS,Fang Q,Sun HY,Xu W,Li WD

    更新日期:2007-04-20 00:00:00

  • Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain.

    abstract:BACKGROUND:Activation of N-methyl-D-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors play an important role in the neurons death induced by ischemia. The mitigating effect of intravenous anesthetics on ischemic neuron injury is related to their influence on NMDA ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang YL,Zhang PB,Qiu SD,Liu Y,Tian YF,Wang Y

    更新日期:2006-09-20 00:00:00

  • Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion.

    abstract:BACKGROUND:Antiphospholipid syndrome (APS)-related immune factors are considered as an important cause of recurrent spontaneous abortion (RSA). Anticoagulant and anti-inflammatory treatments are believed to effectively improve adverse pregnancy outcomes by affecting the abnormal autoimmune response of the maternal-feta...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.207471

    authors: Ye SL,Gu XK,Tao LY,Cong JM,Wang YQ

    更新日期:2017-06-20 00:00:00

  • "Target" and "Sandwich" Signs in Thigh Muscles have High Diagnostic Values for Collagen VI-related Myopathies.

    abstract:BACKGROUND:Collagen VI-related myopathies are autosomal dominant and recessive hereditary myopathies, mainly including Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM). Muscle magnetic resonance imaging (MRI) has been widely used to diagnosis muscular disorders. The purpose of this study was to ev...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.186638

    authors: Fu J,Zheng YM,Jin SQ,Yi JF,Liu XJ,Lyn H,Wang ZX,Zhang W,Xiao JX,Yuan Y

    更新日期:2016-08-05 00:00:00

  • Transcatheter occlusion of multiple aortopulmonary collateral arteries for post-operative heart failure in a patient with tetralogy of Fallot using the Amplatzer vascular plug and a detachable coil.

    abstract::A 10-year-old boy who had previously undergone surgical correction for tetralogy of Fallot was referred for cardiac catheterization because of recurrent symptomatic postoperative heart failure owing to major aortopulmonary collateral arteries (MAPCAs). A successful occlusion of these MAPCAs was achieved percutaneously...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tang L,Zhou SH

    更新日期:2011-03-01 00:00:00