Abstract：
BACKGROUND:P53 is one of the most studied tumor suppressors in the cancer research, and over 50% of human tumors carry P53 mutations. MDM-2 is amplified and/or overexpressed in a variety of human tumors of diverse tissue origin. The aim of this study was to examine the expression of P53 protein and MDM-2 protein in gliomas, and to investigate the relationship between the expression of the two proteins and the histopathological grades of glioma. The relationship between MDM-2 protein expression and P53 protein expression was also analyzed. METHODS:The expression of P53 protein and MDM-2 protein was immunohistochemically detected using monoclonal antibodies in 242 paraffin embedded tissues, including 30 normal brain tissues from patients with craniocerebral injury and 212 tissues from patients with primary glioma (grade I - II group: 5 cases of grade I, 119 cases of grade II; and grade III--IV group: 53 cases of grade III, and 35 cases of grade IV). RESULTS:The P53 positive rate was significantly higher in the glioma groups than in the control group (P < 0.0001). The P53 positive rate was significantly higher in glioma tissues of grade III - IV than in glioma tissues of grade I - II group (P = 0.001). The MDM-2 positive rate was significantly higher in glioma groups than in the control group (P < 0.0001). There was no significant difference in the MDM-2 positive rate between the two glioma groups (P = 0.936). The expression of P53 protein was not related to expression of MDM-2 protein (P = 0.069) CONCLUSIONS:Overexpression of P53 protein might be related to the occurrence and progression of glioma. Overexpression of MDM-2 protein may play an important role in glioma tumorigenesis, but may not be involved in glioma progression. The overexpression of MDM-2 protein was an early event in malignant transformation of glioma. MDM-2 may be a key player in glioma in its own right.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Wang AL,Liu ZX,Li G,Zhang LWsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
2530-3issue
16eissn
0366-6999issn
2542-5641journal_volume
124pub_type
杂志文章abstract：BACKGROUND:The importance of heart rate as secondary prevention strategies for patients with coronary artery disease (CAD) is emphasized by multiple guidelines. However, limited information is available on the heart rate distribution and the change patterns of resting heart rate when initiating beta-blocker therapy amo...
journal_title：Chinese medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Hepatocyte growth factor (HGF) treats ischemic disease by promoting arteriogenesis, however, its mechanism of action is not known. The notch signaling pathway plays an important role in neovascularization. The relationship between the proliferation and migration ability of artery endothelial cells and the Dl...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Asthma is a heterogeneous disease for which a strong genetic basis has been firmly established. Until now no studies have been undertaken to systemically explore the network of asthma-related genes using an internally developed literature-based discovery approach. This study was to explore asthma-related gen...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
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journal_title：Chinese medical journal
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doi：
更新日期：2011-04-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2010-05-20 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
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journal_title：Chinese medical journal
pub_type： 杂志文章,评审
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abstract：:The effects of anisodamine on acetylcholine-induced endothelium-dependent relaxation were studied in organ chambers and under bioassay conditions. In organ chamber experiments, both acetylcholine and bradykinin induced an endothelium-dependent relaxation of norepinephrine-contracted canine femoral arteries in a concen...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2009-08-05 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.1097/CM9.0000000000001252
更新日期：2020-12-03 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2007-05-20 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：10.4103/0366-6999.167362
更新日期：2015-10-20 00:00:00
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pub_type： 杂志文章
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journal_title：Chinese medical journal
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doi：
更新日期：2014-01-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
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doi：
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journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：10.4103/0366-6999.211885
更新日期：2017-08-20 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Pioglitazone may be beneficial in the treatment of psoriasis. However, based on the effectiveness and safety considerations, it has not been widely used. To fully evaluate the strength of evidence supporting psoriasis treatment with pioglitazone, we conducted a meta-analysis of existing published studies. M...
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pub_type： 杂志文章,meta分析
doi：10.1097/CM9.0000000000000642
更新日期：2020-02-20 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
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journal_title：Chinese medical journal
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doi：
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