Evidence of apoptotic smooth muscle cells in proliferative intima of injured arteries.

Abstract:

OBJECTIVE:To investigate the occurrence and extent of apoptosis in the course of restenosis. METHODS:The experimental models of vessel narrowness and intima thickness were established in minipigs' iliac arteries by balloon injury and specimens were retrieved on the 1st, 3rd, 6th, 12th and 30th days for dynamic observation. Apoptotic smooth muscle cells (SMCs) were detected by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). RESULTS:Apoptotic SMCs occurred only in the thickened intima 12 days after injury accompanied with the proliferative SMCs, the percentage of apoptosis was 1.94% +/- 0.42% on the 12th day and 1.36% +/- 0.31% on the 30th day respectively. The low frequency of apoptosis compared with the proliferative SMCs was a feature in the restenotic pathology. CONCLUSIONS:Apoptosis participates in the pathogenetic process of intimal thickening and its level was low compared with proliferation. The findings suggest that attempts to modulate apoptosis after vessel injury constitute a theoretical approach to the prevention of restenosis.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Huang J,Yin H,Leng J,Yao Y,Yao R,Peng T,Li J

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

10-3

issue

1

eissn

0366-6999

issn

2542-5641

journal_volume

113

pub_type

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