Expression of nucleostemin in prostate cancer and its effect on the proliferation of PC-3 cells.

abstract：BACKGROUND:Pancreatic beta-cell apoptosis induced by lipotoxicity, to a large extent, contributes to the progression of type 2 diabetes. To investigate the mechanism of free fatty acid induced apoptosis, we aimed to study the effects of palmitic acid (PA) on the apoptosis and peroxisome proliferator-activated receptor ...

journal_title：Chinese medical journal

authors： He TT,Cao XP,Chen RZ,Zhu XN,Wang XL,Li YB,Xiao HP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive disease associated with a cellular inflammatory response mostly concerned with cigarette smoking. Chemokine receptors CCR1/5 play an important role in the inflammatory cells recruitment in the lung of COPD patients. The aim of this study was to de...

journal_title：Chinese medical journal

authors： Wang F,He B

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between remodeling and dysfunction of left ventricle (LV) and the expression of the angiotensin II AT1 receptor mRNA after myocardial infarction (MI) in rats. METHODS:Nine MI rats (Group A) and 8 sham-operated rats (Group B) were studied by both Doppler echocardiography and Dot ...

journal_title：Chinese medical journal

authors： Zhang G,Yang Y,Pu S,Shen X,Peng T,Chen H

更新日期：1999-07-01 00:00:00

abstract：:Endometriosis is a prevalent chronic disease that affects approximately 6% to 10% of reproductive-aged women. Although numerous researchers have endeavored to explore the etiology of endometriosis over a century, its etiology still remains an enigma. The exploration of pathophysiologic mechanism and novel therapy for ...

journal_title：Chinese medical journal

authors： Gu ZY,Jia SZ,Leng JH

更新日期：2020-07-20 00:00:00

abstract：Background:The increasing frequency of explosive injuries has increased interest in blast-induced traumatic brain injury (bTBI). Various shock tube models have been used to study bTBI. Mild-to-moderate explosions are often overlooked because of the slow onset or mildness of the symptoms. However, heavy gas cylinders an...

journal_title：Chinese medical journal

authors： Zhou Y,Wen LL,Wang HD,Zhou XM,Fang J,Zhu JH,Ding K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:There are no conclusive studies evaluating the interaction between icariin and exercise for treatment of osteoporosis; the efficacy and safety of this treatment combination remains to be evaluated. The purpose of this study was to investigate the effects of icariin treatment combined with exercise therapy on...

journal_title：Chinese medical journal

authors： Liu M,Zhong C,He RX,Chen LF

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Tbx1 is the major candidate gene for DiGeorge syndrome (DGS). Similar to defects observed in DGS patients, the structures disrupted in Tbx1(-/-) animal models are derived from the neural crest cells during development. Although the morphological phenotypes of some Tbx1 knock-down animal models have been well...

journal_title：Chinese medical journal

authors： Zhang LF,Gui YH,Wang YX,Jiang Q,Song HY

更新日期：2010-05-05 00:00:00

abstract：OBJECTIVE:To describe the clinical features, operative methods and postoperative management of the intra-axial tumors of medullocervical junction, and to make differential diagnosis for different subtypes. METHODS:Fifteen patients with intra-axial tumors of medullocervical junction were treated from August 1988 to Jun...

journal_title：Chinese medical journal

authors： Xu Q,Bao W,Mao R,Pang L

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Drug-eluting stents represent a major advance in interventional cardiology. However, the current drug-eluting stents have significant limitations. One of the major problems is very late stent thrombosis, which is likely caused by inflammation and a hypersensitivity reaction related to a polymer on the stent....

journal_title：Chinese medical journal

authors： Chen M,Zheng B,Wu Z,Peng HY,Wang XG,Zhang B,Huo Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common condition, which affects not only the quality of life of patients but also their prognosis. The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the gluco...

journal_title：Chinese medical journal

authors： Xiao Y,Su L,Han B,Zhang X,Xie L

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To test the immunosuppressive effect of cyclosporine (Cs) in a polymer placed in the anterior chamber of corneal allograft recipients. METHODS:Wistar inbred rats with vascularized corneas were recipients of corneal allografts from Sprague-Dawley donor rats. Rats underwent penetrating keratoplasty and were di...

journal_title：Chinese medical journal

authors： Xie L,Shi W,Wang Z,Bei J,Wang S

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of gypenosides (Gs) on cellular immunocompetence in the gamma-ray-irradiated mice. MATERIALS AND METHODS:Tested mice of ICR strain were treated continuously with Gs for 10 days before or after 4 Gy gamma-irradiation. Body weight and splenic weight of mice were measured. The blastog...

journal_title：Chinese medical journal

authors： Hau DM,Feng Y,Chen WC,Lin IH,Chen KT,Lin SS,Wang MI

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Hypertension is an important risk factor of cardiovascular disease and increases mortality in the elderly. However, the available medical evidences are both inconsistent and insufficient regarding establishing credible and useful blood pressure (BP) targets in the hypertensive elderly. This review summarizes ...

journal_title：Chinese medical journal

authors： Liu P,Zheng JG

更新日期：2017-08-20 00:00:00

abstract：OBJECTIVE:Physiologic cardiac pacing is a novel technique which has been largely popularized in recent decades. His bundle pacing (HBP) has been long considered the most physiologic pacing method; however, with the widespread implementation of this method, its disadvantages have become apparent. In this context, left b...

journal_title：Chinese medical journal

authors： Cheng LT,Zhang JM,Wang ZF,Gao HK,Wu YQ

更新日期：2019-01-20 00:00:00

abstract：OBJECTIVE:To investigate the effect of L-arginine (L-arg) on early compensatory renal growth (CRG), tubulointerstitial accumulation of extracellular matrix (ECM), long term survival rate and renal scarring in rats with 5/6 nephrectomy (SNx). METHODS:The experiment included four groups of rats (n = 5 each group): (1) S...

journal_title：Chinese medical journal

authors： Liu B,Haylor J,El Nahas AM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Acinetobacter baumannii is one of the main gram-negative bacilli in clinical practice. Nosocomial infections caused by multi-drug resistance Acinetobacter baumannii is very difficult to treat. This study was designed to investigate the antimicrobial resistance characteristics and four resistant gene expressi...

journal_title：Chinese medical journal

authors： Shi WF,Jiang JP,Mi ZH

更新日期：2005-01-20 00:00:00

abstract：BACKGROUND:Sunitinib has been proved an effective new option for treatment of metastatic renal cell carcinoma (mRCC). Analysis of clinical data of 22 patients, who were exposed to sunitinib for at least 1 year, was conducted to evaluate the long-term efficacy and safety of sunitinib for the treatment of mRCC. METHODS:...

journal_title：Chinese medical journal

authors： Zhang CJ,Zhao PJ,Li XS,Zhao J,Huang LH,Song Y,Gong K,Shen C,Yu W,Song G,Zhao Z,Zhang Z,Zhang Q,He ZS,Jin J,Zhou LQ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs). We investigated the differences of MMP-2 expression between LV and RV in response to nandrolone decanoate (ND), swimming training (ST), and combined ND and ST (NS) in mice, based on...

journal_title：Chinese medical journal

authors： Bai Y,Shi XB,Zhang YQ,Wang YL,Liu XY,Esteve-Pastor MA

更新日期：2018-01-20 00:00:00

abstract：:Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

journal_title：Chinese medical journal

authors： Zhuang YY,Li JJ,Wang JJ

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:To explore the characteristics of Helicobacter pylori (H. pylori) antigen in serum and to evaluate its clinical diagnostic value. METHODS:Enzyme-linked immunosorbant assay (ELISA) was developed to detect the soluble H. pylori antigen (S-Hp) and circulatory specific H. pylori antigen immunocomplexes (Hp-IC) i...

journal_title：Chinese medical journal

authors： Zhu Y,Lin J,Li D,Du Q,Qian K,Wu Q,Zheng S

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:To assess the feasibility and efficacy of eliciting leukemia-specific T-cell responses in syngeneic mice in vitro and in vivo using dendritic cells (DCs) pulsed with total RNA from leukemia cells. METHODS:DCs generated from bone marrow culture in vitro in the presence of combined cytokines were pulsed with ...

journal_title：Chinese medical journal

authors： Li M,You S,Ge W,Ma S,Ma N,Zhao C

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Pulsed radiofrequency (PRF) application to the dorsal root ganglia can reduce neuropathic pain (NP) in animal models, but the effect of PRF on damaged peripheral nerves has not been examined. We investigated the effect of PRF to the rat sciatic nerve (SN) on pain-related behavior and SN ultrastructure follow...

journal_title：Chinese medical journal

authors： Li DY,Meng L,Ji N,Luo F

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:The tibial plateau is asymmetric with a larger medial plateau. We observed from clinical practice that the shape of the tibial plateau does not always present a larger medial plateau. Tibial plateau also showed other shapes. The purpose of this study was to analyze the anthropometric data of the proximal tib...

journal_title：Chinese medical journal

authors： Yang B,Yu J,Gong X,Chen L,Wang Y,Wang J,Wang H,Zhang J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Metformin is the most widely used anti-diabetic drug in the world. An increasing body of evidence shows metformin also blocks cell cycle progression and selectively induces apoptosis via caspase activation in some breast tumor cells. Diffusion-weighted imaging (DWI) and bioluminescence imaging (BLI) have gre...

journal_title：Chinese medical journal

authors： Mao Y,Xia R,Wang L,Wang YQ,Gao FB

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there is need for new treatment regimens. In this study, we assessed the efficacy and safety of secukinumab in Chinese patients with moderat...

journal_title：Chinese medical journal

authors： Cai L,Zhang JZ,Yao X,Gu J,Liu QZ,Zheng M,Zhang SF,Xu JH,Li CX,Cheng H,Guo Q,Pan WL,Li SQ,Li RY,Guo ZP,Song ZQ,Li SS,Dong XQ,Wang L,Fu R,Regnault P,Charef P,Mazur R,Patekar M

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:The most important objective of transplant studies in the injured spinal cord has been to provide a favorable environment for axonal growth. Moreover, the continuing discovery of new grafts is providing new potentially interesting transplant candidates. Our purpose was to observe the morphological and functi...

journal_title：Chinese medical journal

authors： Chen G,Hu YR,Wan H,Xia L,Li JH,Yang F,Qu X,Wang SG,Wang ZC

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Inflammation and coagulation are two intimately cross-linked defense mechanisms of most, if not all organisms to injuries. During cardiopulmonary bypass (CPB), these two processes are activated and interact with each other through several common pathways, which may result in subsequent organ dysfunction. In ...

journal_title：Chinese medical journal

authors： Zhou J,Wu XD,Lin K,Lui RC,An Q,Tao KY,Du L,Liu J

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To explore the involvement of calcium in the mechanism of hypoxic/hypoglycemic insults and nerve growth factor (NGF) protection. METHODS:Neuron viability and lactate dehydrogenase (LDH) efflux in the bathing medium in cerebral cortex cultures from fetal rats were measured. Calcium fluorescent indicator Fura-...

journal_title：Chinese medical journal

authors： Wu J,Zhang J

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To study the interruptive effect of hepatitis B virus (HBV) specific immunolobulin (HBIG) before delivery in attempt to prevent intrauterine transmission of HBV. METHODS:Nine hundred and eighty HBsAg carrier pregnant women were randomly divided into HBIG group and control group. Each subject in the HBIG grou...

journal_title：Chinese medical journal

authors： Zhu Q,Yu G,Yu H,Lu Q,Gu X,Dong Z,Zhang X

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Cholesterol-lowering therapy with statins has been reported to reduce the morbidity and mortality of cardiovascular diseases. This study aimed to investigate the effects of combined application of extended-release niacin and atorvastatin on lipid profile modification and the risks of adverse events in patien...

journal_title：Chinese medical journal

authors： Sang ZC,Wang F,Zhou Q,Li YH,Li YG,Wang HP,Chen SY

更新日期：2009-07-20 00:00:00