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Establishment of endometriotic models: the past and future.

Abstract：

:Endometriosis is a prevalent chronic disease that affects approximately 6% to 10% of reproductive-aged women. Although numerous researchers have endeavored to explore the etiology of endometriosis over a century, its etiology still remains an enigma. The exploration of pathophysiologic mechanism and novel therapy for endometriosis depends on ideal endometriotic models. In the previous decade, various endometriotic models have been established; therefore, we made a conclusion for available information on these models. This review summarized the common experimental models used in endometriotic studies, including their origins, characteristics, applications, and limitations. Endometriotic models played an important role in studying etiologies and novel treatments of endometriosis during the last decades. Among them, animal models and endometriotic cell lines were viewed as most common studying tools to explore the intrinsic entities of endometriosis. In addition, endometrial organoid also emerged and was regarded as an ideal studying tool for endometriosis research. Different research models collectively complement each other to advance the endometriosis research. The successful establishment of endometrial organoids means that organoids are expected to become an ideal model for studying endometriosis in the future.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Gu ZY,Jia SZ,Leng JH

doi

10.1097/CM9.0000000000000885

subject

Has Abstract

pub_date

2020-07-20 00:00:00

pages

1703-1710

issue

14

eissn

0366-6999

issn

2542-5641

pii

00029330-202007200-00010

journal_volume

133

pub_type

杂志文章

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