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Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study.

Abstract：

BACKGROUND:With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. METHODS:All infants admitted to 26 NICUs with a birth weight (BW) < l000 g were included between January l, 2011 and December 31, 2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. RESULTS:A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age (GA) was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants (23.3%) died and another 69 infants (26.7%) died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas (53.6% vs. 35.3%, P = 0.019). BW < 750 g and GA < 28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. CONCLUSIONS:Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Lin HJ,Du LZ,Ma XL,Shi LP,Pan JH,Tong XM,Li QP,Zhou JG,Yi B,Liu L,Chen YB,Wei QF,Wu HQ,Li M,Liu CQ,Gao XR,Xia SW,Li WB,Yan CY,He L,Liang K,Zhou XY,Han SP,Lyu Q,Qiu YP,Li W,Chen DM,Lu HR,Liu XH,Li

doi

10.4103/0366-6999.167312

subject

Has Abstract

pub_date

2015-10-20 00:00:00

pages

2743-50

issue

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2015_128_20_2743_167312

journal_volume

128

pub_type

杂志文章,多中心研究

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Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study.