Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats.

Abstract:

:The depth and area-percentage of Alcian blue (AB) staining of glomeruli, the ability of RBC to bind AB and the onset of proteinuria in adriamycin nephrosis in rats were studied. The results showed that the negative charge (NC) on RBC and glomeruli decreased significantly after injection of adriamycin and there was a positive correlation between them (r = 0.77, P less than 0.01). There was a negative correlation between the amount of NC on the RBC and the amount of urinary protein (r = -0.5231, P less than 0.01), and also between the amount of NC on the glomeruli and the amount of urinary protein (r = -0.5140, P less than 0.05).

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Chen ZY,Jiang XY

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

573-6

issue

7

eissn

0366-6999

issn

2542-5641

journal_volume

104

pub_type

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