Effect of Q-switched Alexandrite laser irradiation on epidermal melanocytes in treatment of Nevus of Ota.

Abstract:

OBJECTIVE:To investigate injury to epidermal melanocyte by Q-switched Alexandrite laser. METHODS:Multiple biopsies were performed on 5 patients with nevus of Ota from before irradiation to 1 year after irradiation. Fourteen specimens were obtained for light microscopy, and 17 for transmission electron microscopy. RESULTS:Melanosomes in epidermal melanocytes were both smaller in size and fewer in number than those in dermal melanocytes. Immediately after irradiation, focal extracellular vacuoles of the basal layer could be observed under light microscopy. Most epidermal melanocytes underwent mild or moderate injury in the form of vacuolated melanosomes, swollen mitochondria, dilation of endoplasmic reticulum, and expansion of extracellular space, retaining intact cell membranes. Normal structures were restored 5 months to 1 year after irradiation, with no depigmentation or hyperpigmentation as seen by light microscopy. CONCLUSION:Injury of melanosomes in epidermal melanocytes is reversible.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Lu Z,Chen J,Wang X,Fang L,Jiao S,Huang W

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

597-601

issue

4

eissn

0366-6999

issn

2542-5641

journal_volume

116

pub_type

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