Abstract:
:Cells need to process multifaceted external cues to steer their dynamic behavior. To efficiently perform this task, cells implement several exploratory mechanisms to actively sample their environment. In particular, cells can use exploratory actin-based cell protrusions and contractions to engage and squeeze the environment and to actively probe its chemical and mechanical properties. Multiple excitable signal networks were identified that can generate local activity pulses to control these exploratory processes. Such excitable signal networks offer particularly efficient mechanisms to process chemical or mechanical signals to steer dynamic cell behavior, such as directional migration, tissue morphogenesis and cell fate decisions.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Nalbant P,Dehmelt Ldoi
10.1515/hsz-2017-0341subject
Has Abstractpub_date
2018-07-26 00:00:00pages
809-819issue
8eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2017-0341/hsz-2017-0341.journal_volume
399pub_type
杂志文章,评审abstract::Neuritic plaques of Alzheimer patients are composed of multiple protein components. Among them, the amyloid beta-peptides (Abeta) 1-40/42 and further N- and C-terminally modified fragments of Abeta are highly abundant. Most prominent are the isoaspartate (isoAsp)-Abeta peptides and pyroglutamyl (pGlu)-Abeta. While pGl...
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