Digital image analysis improves precision of PD-L1 scoring in cutaneous melanoma.

abstract：AIMS:To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan and the association with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV). METHODS AND RESULTS:We investigated retrospectively 26 cases with a median age of 76.5. O...

journal_title：Histopathology

authors： Chen BJ,Wang RC,Ho CH,Yuan CT,Huang WT,Yang SF,Hsieh PP,Yung YC,Lin SY,Hsu CF,Su YZ,Kuo CC,Chuang SS

更新日期：2018-05-01 00:00:00

abstract：AIMS:Adenoviral inclusions are commonly seen in appendices from infants with intussusception. They are associated with focal epithelial budding and less frequently with epithelial shedding. These morphological changes could depend on the opposing effects of adenoviral gene products on CD95-mediated apoptosis. METHODS ...

journal_title：Histopathology

authors： Larousserie F,Berrebi D,Florentin A,De Lagausie P,Aigrain Y,Peuchmaur M

更新日期：1997-10-01 00:00:00

abstract：AIMS:Hodgkin lymphoma treatments are largely based on the generation of reactive oxygen species, but increased expression of antioxidant enzymes may contribute to chemoresistance. The aims of this study were: to define the extent and prognostic value of oxidative stress marker and antioxidant enzyme expression in Hodgk...

journal_title：Histopathology

authors： Bur H,Haapasaari KM,Turpeenniemi-Hujanen T,Kuittinen O,Auvinen P,Marin K,Koivunen P,Sormunen R,Soini Y,Karihtala P

更新日期：2014-09-01 00:00:00

abstract：:Two cases of tubulovillous adenoma and adjacent colonic mucosa were studied in which intestinal spirochaetosis had heavily colonized the non-neoplastic but not the neoplastic epithelium. Ultrastructural and histochemical studies were performed and we postulate that the reason for this disparity is the normal microvill...

journal_title：Histopathology

authors： Coyne JD,Curry A,Purnell P,Haboubi NY

更新日期：1995-10-01 00:00:00

abstract：:To elucidate the role of cell turnover in primary gastric B-cell non-Hodgkin's lymphomas we studied tissue samples of 72 patients-26 small cell (25 MALT lymphomas) and 46 large cell (31 MALT lymphomas). Proliferation indices and apoptotic indices were measured by Mib-1 expression and terminal deoxynucleotidyltransfera...

journal_title：Histopathology

authors： Gisbertz IA,Schouten HC,Bot FJ,Arends JW

更新日期：1997-02-01 00:00:00

abstract：AIMS:Polymorphous low-grade adenocarcinoma (PLGA) is the second most common type of malignant neoplasm in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. Herein, we present three cases of de novo PLGA arising in major salivary glands. METHODS AND RESULTS:Three cases of PLGA w...

journal_title：Histopathology

authors： Nagao T,Gaffey TA,Kay PA,Minato H,Serizawa H,Lewis JE

更新日期：2004-02-01 00:00:00

abstract：AIMS:To develop a method to preserve lipids in formalin-fixed tissues for staining in paraffin sections, and to illustrate its use in lung and brain of a fat embolism case, and in examples of fatty liver and atheroma. METHODS AND RESULTS:A saturated solution of linoleic acid in 70% ethylene glycol was prepared and tis...

journal_title：Histopathology

authors： Tracy RE,Walia P

更新日期：2002-07-01 00:00:00

abstract：AIMS:To undertake a clinicopathological study of diffuse serosal neoplasms of epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma. METHODS AND RESULTS:Over a 10-year (1990-2000) study period 53 carcinomas mimicking diffuse pleural mesothelioma ('pseudomesotheliomatous' carc...

journal_title：Histopathology

authors： Attanoos RL,Gibbs AR

更新日期：2003-11-01 00:00:00

abstract：:The clinical, light microscopic and immunohistochemical features of six cutaneous heterotopic meningeal nodules (primary, or type I, cutaneous meningiomas) are described. These are rare lesions of the scalp and back which generally present at birth or in childhood. They appear as small subcutaneous fibrous nodules, wi...

journal_title：Histopathology

authors： Theaker JM,Fletcher CD,Tudway AJ

更新日期：1990-05-01 00:00:00

abstract：:A recently developed and validated histochemical method--immunogold-streptavidin enhancement--was used to determine oestrogen receptor content in paraffin sections of breast cancers. The selection of the best cut-off point to define oestrogen receptor status as rich or poor was made on the basis of survival data, usin...

journal_title：Histopathology

authors： Cowen PN,Teasdale J,Jackson P,Reid BJ

更新日期：1990-10-01 00:00:00

abstract：AIMS:To evaluate concordance, upgrades and downgrades from biopsy to prostatectomy, and associated clincopathological parameters, using the recently proposed Gleason grade groups/International Society of Urologic Pathology (ISUP) grades. METHODS AND RESULTS:We evaluated 2529 patients who underwent biopsy and prostatec...

journal_title：Histopathology

authors： Athanazio D,Gotto G,Shea-Budgell M,Yilmaz A,Trpkov K

更新日期：2017-06-01 00:00:00

abstract：AIMS:Pathological or neuroprotective mechanisms in the brain in severe malaria may arise from microvascular obstruction with malaria-parasitized erythrocytes. This study aimed to investigate the role of hypoxia and induction of the vascular endothelial growth factor (VEGF) pathway in the neuropathophysiology of severe ...

journal_title：Histopathology

authors： Medana IM,Day NP,Roberts R,Sachanonta N,Turley H,Pongponratn E,Hien TT,White NJ,Turner GD

更新日期：2010-08-01 00:00:00

abstract：:A large variety of lymphoma types may develop as primary intestinal neoplasms in the small intestines or, less often, in the colorectum. Among these are a few entities such as enteropathy-associated T-cell lymphoma or immunoproliferative small intestinal disease that, essentially, do not arise elsewhere than in the ga...

journal_title：Histopathology

authors： Foukas PG,de Leval L

更新日期：2015-01-01 00:00:00

abstract：AIMS:Maspin, a protein belonging to the serpin superfamily, is the product of a tumour suppressor gene. Tissue distribution studies have shown maspin expression in normal mammary epithelial cells, in the placenta, prostate, thymus, testis, oral cavity, small intestine, skin, and cornea. Maspin is expressed but down-reg...

journal_title：Histopathology

authors： Marioni G,Blandamura S,Giacomelli L,Calgaro N,Segato P,Leo G,Fischetto D,Staffieri A,de Filippis C

更新日期：2005-05-01 00:00:00

abstract：AIMS:Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immun...

journal_title：Histopathology

authors： Lee DY,Park JH,Shin HT,Yang JM,Jang KT,Kwon GY,Lee KH,Shim JS

更新日期：2012-07-01 00:00:00

abstract：AIMS:Although delayed hypopituitarism is a common complication of conventional radiotherapy of sellar tumours, histological changes that may account for it have been rarely reported. To elucidate the changes, hypofunctional pituitary glands following irradiation were studied. METHODS AND RESULTS:Two pituitary glands o...

journal_title：Histopathology

authors： Nishioka H,Ito H,Haraoka J,Hirano A

更新日期：2001-06-01 00:00:00

abstract：AIMS:To investigate the expression and the prognostic role of glycoprotein Tenascin-C (Tn-C) in primary melanoma of the skin. METHODS AND RESULTS:The immunohistochemical expression of Tn-C was studied in 98 primary melanomas and related to inflammation, invasion, and patient outcome. Patients were followed up for dise...

journal_title：Histopathology

authors： Ilmonen S,Jahkola T,Turunen JP,Muhonen T,Asko-Seljavaara S

更新日期：2004-10-01 00:00:00

abstract：:Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B-cell lymphomas can be subdivided into entities that typically ...

journal_title：Histopathology

authors： Zamò A,Johnston P,Attygalle AD,Laurent C,Arber DA,Fend F

更新日期：2020-09-01 00:00:00

abstract：AIMS:Neuropilin-2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin-2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study was to validate a protocol for the evaluation of neuropilin-2 protein expression in situ, by comparison with in-situ ...

journal_title：Histopathology

authors： Jubb AM,Sa SM,Ratti N,Strickland LA,Schmidt M,Callahan CA,Koeppen H

更新日期：2012-09-01 00:00:00

abstract：AIMS:We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus. METHODS AND RESULTS:The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies. Grossly, all tumours were present in the uterine body, an...

journal_title：Histopathology

authors： Watanabe K,Ogura G,Suzuki T

更新日期：2003-04-01 00:00:00

abstract：AIMS:We compared the immunohistochemical profiles of the rete ovarii and endometriosis in order to identify a panel which distinguishes between these structures. The immune profiles of the epoophoron, Fallopian tube and ovarian surface epithelium were also studied. MATERIALS AND METHODS:Twenty-four women with no evide...

journal_title：Histopathology

authors： Russo L,Woolmough E,Heatley MK

更新日期：2000-07-01 00:00:00

abstract：AIMS:Rosette-forming malignant lymphoma is very rare. We report a blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase (TdT) with formation of Homer-Wright type pseudorosettes. METHODS AND RESULTS:An 18-year-old boy presented with an enlarged inguinal lymph node. Histologically, the nodal architec...

journal_title：Histopathology

authors： Ko YH,Kim SH,Ree HJ

更新日期：1998-12-01 00:00:00

abstract：AIMS:MYC is a proto-oncogene that is frequently dysregulated in various malignancies, through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification, and immunohistochemical expression has been shown to be a reliable surrogate marker for amplification, but less is known abo...

journal_title：Histopathology

authors： Mito JK,Qian X,Jo VY,Doyle LA

更新日期：2020-10-01 00:00:00

abstract：AIMS:Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterized by malignant transformation of a pre-existing benign trichoblastoma and subdivided histologically into low- and high-grade tumours. While morphologically low-grade trichoblastic carcinomas show an indolent b...

journal_title：Histopathology

authors： Mehta A,Davey J,Wiedemeyer K,Brenn T

更新日期：2021-01-03 00:00:00

abstract：AIMS:To determine the frequency of point mutation in c-kit in CD117+ small cell lung cancer (SCLC). A significant proportion of SCLCs have been documented to be CD117+, thereby signifying they express the c-kit gene product. This finding suggests this tumour may be a potential target for tyrosine kinase inhibitor (TKI)...

journal_title：Histopathology

authors： Mojica WD,Saxena R,Starostik P,Cheney RT

更新日期：2005-11-01 00:00:00

abstract：:Histological features were semi-quantitatively analysed in 60 livers, obtained by necropsy, from patients who died of South American blastomycosis. These findings were classified and correlated with duration of the disease and treatment. Bile-duct lesions were prominent and a particular pattern was found in which segm...

journal_title：Histopathology

authors： Teixeira F,Gayotto LC,De Brito T

更新日期：1978-07-01 00:00:00

abstract：AIMS:Angiogenesis is essential for tumour growth and metastasis and tumour necrosis factor (TNF)-alpha is a potent angiogenic factor. Invasive micropapillary carcinoma of the breast (IMPC), a rare subtype of breast cancer, possesses a lymphotropic nature with a high incidence of lymph node metastasis and poor prognosis...

journal_title：Histopathology

authors： Cui LF,Guo XJ,Wei J,Liu FF,Fan Y,Lang RG,Gu F,Zhang XM,Fu L

更新日期：2008-10-01 00:00:00

abstract：AIMS:This study aimed to assess the feasibility of using virtual slides to create 3D histopathological reconstructions to aid in the study of the biology of DCIS. METHODS:Four μm thick serial sections of formalin fixed paraffin embedded tissue from three cases were cut and mounted onto glass slides, stained with haema...

journal_title：Histopathology

authors： Booth ME,Treanor D,Roberts N,Magee DR,Speirs V,Hanby AM

更新日期：2015-06-01 00:00:00

abstract：AIMS:Thymic carcinoma is rare and usually has a fatal outcome. Gene mutations in the epidermal growth factor receptor (EGFR) signalling pathway and TP53 have not been well analysed in thymic carcinoma. METHODS AND RESULTS:We examined a large cohort of thymic carcinoma and thymoma type A/B3 and looked for gene mutation...

journal_title：Histopathology

authors： Sakane T,Murase T,Okuda K,Saida K,Masaki A,Yamada T,Saito Y,Nakanishi R,Inagaki H

更新日期：2019-11-01 00:00:00

abstract：:Pancreatic acinar metaplasia of the gastric mucosa is a newly recognized entity. Its physiological relevance and association with other pathological conditions in the stomach remain to be elucidated. We studied by immunohistochemistry the expression of growth markers in the gastric mucosa in biopsies from 15 patients ...

journal_title：Histopathology

authors： Stachura J,Konturek J,Urbańczyk K,Bogdal J,Domschke W

更新日期：1995-12-01 00:00:00