Aggressive B-cell lymphomas with a primary bone marrow presentation.

Abstract:

:Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B-cell lymphomas can be subdivided into entities that typically present primarily in the BM, and cases with BM involvement in which the bulk of disease is present in other organs. One main topic at the 2018 BM workshop of the European Association of Haematopathology/Society of Hematopathology was therefore aggressive B-cell lymphomas with a primary BM presentation. The spectrum of cases submitted to this topic gave a good overview of commonly encountered problems, as well as unusual manifestations, and highlighted areas of imprecise disease definitions and diagnostic grey zones. The categories submitted to the workshop included cases of Burkitt lymphoma (BL) with unusual features, high-grade B-cell lymphomas (HG-BCLs) with and without so-called double/triple-hit, and diffuse large B-cell lymphomas (DLBCLs) with a primary BM presentation. Areas of difficulties included the morphological boundaries of HG-BCL not otherwise specified, cases with MYC and bcl-2 or bcl-6 translocations and terminal deoxynucleotidyl transferase (TdT) expression, which were categorised as B-cell lymphoblastic leukaemia/lymphoma if most cells showed TdT positivity, and the clinicopathological overlap between intravascular large B-cell lymphoma, CD5-positive DLBCL, and DLBCL with primary presentations in the BM, spleen, and liver. This review summarises our understanding of the main aggressive B-cell lymphoma categories with a common primary BM presentation and potential problem areas, and makes suggestions for the immunophenotypic and genetic work-up, illustrated by the interesting and challenging cases submitted to the workshop.

journal_name

Histopathology

journal_title

Histopathology

authors

Zamò A,Johnston P,Attygalle AD,Laurent C,Arber DA,Fend F

doi

10.1111/his.14124

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

369-379

issue

3

eissn

0309-0167

issn

1365-2559

journal_volume

77

pub_type

杂志文章
  • Morphological and immunophenotypic variations in malignant melanoma.

    abstract::A variety of cytomorphological features, architectural patterns and stromal changes may be observed in malignant melanomas. Hence, melanomas may mimic carcinomas, sarcomas, benign stromal tumours, lymphomas, plasmacytomas and germ cell tumours. Melanomas may be composed of large pleomorphic cells, small cells, spindle...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2559.2000.00894.x

    authors: Banerjee SS,Harris M

    更新日期:2000-05-01 00:00:00

  • Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour.

    abstract:AIMS:Several studies have demonstrated that Na(+) /H(+) exchanger regulatory factor 1 (NHERF1) protein, which is overexpressed and heterogeneously distributed in different stages of breast cancer, could be used as a tumour marker for prognosis in molecular detection strategies. We observed that tumour-infiltrated lymph...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2011.03844.x

    authors: Bellizzi A,Mangia A,Malfettone A,Cardone RA,Simone G,Reshkin SJ,Paradiso A

    更新日期:2011-06-01 00:00:00

  • Amyloidosis.

    abstract::Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils which are derived from different proteins in different forms of the disease. Asymptomatic amyloid deposition in a variety of tissues is a universal accompaniment of ageing, and clinical amyloidosis i...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.1994.tb00001.x

    authors: Tan SY,Pepys MB

    更新日期:1994-11-01 00:00:00

  • Immunophenotyping of Nigerian cases of non-Hodgkin's lymphomas on paraffin sections.

    abstract::One hundred cases of routinely fixed and processed non-Hodgkin's lymphoma from Nigeria were immunostained with a small panel of monoclonal antibodies against B-, T- and macrophage antigens. The aims of the study were to assess the suitability of stored material from a country like Nigeria for immunohistochemical exami...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1991.tb01476.x

    authors: Thomas JO,Rafindadi A,Heryet A,Jones M,Gatter KC,Mason DY

    更新日期:1991-06-01 00:00:00

  • Variable fidelity of tissue-marking dyes in surgical pathology.

    abstract:AIMS:Pathology specimens often contain important margins that must be identified from gross examination of specimens through to microscopic examination. Commonly, unique colours of tissue-marking dye (TMD) are applied to each margin, which facilitates both macroscopic and microscopic identification. Various techniques ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12328

    authors: Williams AS,Dakin Haché K

    更新日期:2014-05-01 00:00:00

  • Overexpression of TNF-alpha and TNFRII in invasive micropapillary carcinoma of the breast: clinicopathological correlations.

    abstract:AIMS:Angiogenesis is essential for tumour growth and metastasis and tumour necrosis factor (TNF)-alpha is a potent angiogenic factor. Invasive micropapillary carcinoma of the breast (IMPC), a rare subtype of breast cancer, possesses a lymphotropic nature with a high incidence of lymph node metastasis and poor prognosis...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2008.03128.x

    authors: Cui LF,Guo XJ,Wei J,Liu FF,Fan Y,Lang RG,Gu F,Zhang XM,Fu L

    更新日期:2008-10-01 00:00:00

  • Non-systemic diffuse lymphangiomatosis of spleen and liver.

    abstract::We present a 27-year-old woman with non-systemic diffuse lymphangiomatosis of spleen and liver. The tumour consisted of capillary and cavernous lymphatic vessels located in abundant fibrous tissue. The vascular endothelium showed immunoreactivity for factor VIII-related antigen. A basal lamina could be demonstrated im...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1991.tb00884.x

    authors: Schmid C,Beham A,Uranüs S,Melzer G,Auböck L,Seewann HL,Klimpfinger M

    更新日期:1991-05-01 00:00:00

  • Lack of cyclin D1 overexpression in gastric carcinogenesis.

    abstract:AIMS:Cyclin D1 overexpression was examined in early gastric carcinomas and precursor lesions with the following aims; (1) to assess the chronology of cyclin D1 overexpression in various stages of gastric carcinogenesis, (2) to correlate cyclin D1 overexpression with the Lauren type, the grade of differentiation and the...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2000.00798.x

    authors: Blok P,Craanen ME,van Diest PJ,Dekker W,Tytgat GN

    更新日期:2000-02-01 00:00:00

  • Updates in the approach to intrathoracic sarcomas.

    abstract::Primary intrathoracic sarcomas constitute a rare, heterogeneous group of neoplasms that occur in the lung parenchyma, pleura, and mediastinum. Although pathologically diverse, they frequently show similar clinical and radiological features, and accurate histopathological diagnosis is therefore crucial for correct mana...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/his.12771

    authors: Thway K,Jordan S,Fisher C,Nicholson AG

    更新日期:2015-12-01 00:00:00

  • Large cell lymphoma of the mediastinum: a B-cell tumour of probable thymic origin.

    abstract::Fifteen cases of non-Hodgkin's lymphoma of the anterior mediastinum are reported. In the first group of four, fresh tissue was available and immunohistochemical studies demonstrated their B-cell origin, with monotypic immunoglobulin production in two. Only fixed tissue was available in the second group of 11 patients....

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1986.tb02491.x

    authors: Addis BJ,Isaacson PG

    更新日期:1986-04-01 00:00:00

  • Is pseudomelanosis coli a marker of colonic neuropathy in severely constipated patients?

    abstract:AIMS:To study relationships between the number of pseudomelanosis coli cells and that of colonic enteric neurons and interstitial cells of Cajal, which are significantly reduced compared with controls in severely constipated patients. Pseudomelanosis coli is frequent in patients using anthraquinone laxatives. It is not...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2006.02481.x

    authors: Villanacci V,Bassotti G,Cathomas G,Maurer CA,Di Fabio F,Fisogni S,Cadei M,Mazzocchi A,Salerni B

    更新日期:2006-08-01 00:00:00

  • Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma.

    abstract:AIMS:Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NP...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02920.x

    authors: Segawa Y,Oda Y,Yamamoto H,Uryu H,Shiratsuchi H,Hirakawa N,Tomita K,Yamamoto T,Oda S,Yamada T,Komune S,Tsuneyoshi M

    更新日期:2008-01-01 00:00:00

  • Histopathology and the 'third great lie'. When is an image not a scientifically authentic image?

    abstract::This article considers the issues of image manipulation within the context of electronic/digital images. The possibility for such alterations has occurred with the increasing availability of simple and cheap computer software, permitting modification of digitized images as a whole, or in part. The concepts of acceptab...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2559.2001.01312.x

    authors: Suvarna SK,Ansary MA

    更新日期:2001-11-01 00:00:00

  • Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade.

    abstract:AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2004.01893.x

    authors: Jerome Marson V,Mazieres J,Groussard O,Garcia O,Berjaud J,Dahan M,Carles P,Daste G

    更新日期:2004-08-01 00:00:00

  • Waldeyer ring lymphomas. A clinicopathological study of 79 cases.

    abstract::Waldeyer ring lymphomas belong to a category of tumours which has not yet been fully defined. Their relation to mucosa-associated lymphoid tissue (MALT) and other extranodal lymphomas remains largely unknown. We performed a clinicopathological retrospective study of 79 patients, and compared them with a series of MALT...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1994.tb01266.x

    authors: Menárguez J,Mollejo M,Carrión R,Oliva H,Bellas C,Forteza J,Martin C,Ruiz-Marcellán C,Morente M,Romagosa V

    更新日期:1994-01-01 00:00:00

  • Sensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports.

    abstract:AIMS:A systematic review of published reports that have evaluated the ability of immunohistochemistry and argyrophil nucleolar organizing region (AgNOR) staining to distinguish between benign and malignant pleural disease. METHODS:Nineteen relevant papers published during the period 1979-2005 were identified. Individu...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2006.02442.x

    authors: King J,Thatcher N,Pickering C,Hasleton P

    更新日期:2006-12-01 00:00:00

  • Capillary apposition and density in the diagnosis of alveolar capillary dysplasia.

    abstract:AIM:Alveolar capillary dysplasia (ACD) is a rare disorder, typically presenting with persistent pulmonary hypertension of the newborn. The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome. METHODS AND RESULTS:Three pa...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2008.03134.x

    authors: Melly L,Sebire NJ,Malone M,Nicholson AG

    更新日期:2008-10-01 00:00:00

  • Herpetic salpingitis and fallopian tube prolapse.

    abstract:AIM:We describe the unusual association of fallopian tubal prolapse and herpetic infection, an occurrence not previously reported to our knowledge. METHODS AND RESULTS:A 37-year-old woman presented with a small polypoid mass of the vaginal vault, 3 months after abdominal hysterectomy and abdominoplasty. The vaginal ma...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1999.00644.x

    authors: Lefrancq T,Orain I,Michalak S,Hourseau M,Fetissof F

    更新日期:1999-06-01 00:00:00

  • BNIP3 expression in follicular lymphoma.

    abstract:AIMS:To investigate the role of BNIP3, a 19-kDa interacting protein of the Bcl-2 family, alongside Bcl-2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase-3 (apoptotic markers) and Ki67 (proliferation marker). METHODS AND RESULTS:Immunohi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02657.x

    authors: Sington J,Giatromanolaki A,Campo L,Turley H,Pezzella F,Gatter KC

    更新日期:2007-04-01 00:00:00

  • VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours.

    abstract:AIMS:More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and the receptor VEGFR-3. METHODS AND RESULTS:...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2012.04307.x

    authors: Ramani P,Nash R,Radevsky L,Patel A,Luckett M,Rogers C

    更新日期:2012-12-01 00:00:00

  • Gastrointestinal lymphoproliferative disorders.

    abstract::Malignant lymphomas can be first detected in some patients in endoscopic biopsies of the gastrointestinal (GI) tract. However, their recognition and accurate classification often pose problems for the pathologist for several reasons. First, the small sampling size limits pattern recognition and the number of ancillary...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2006.02571.x

    authors: Banks PM

    更新日期:2007-01-01 00:00:00

  • What to do with high autofluorescence background in pancreatic tissues - an efficient Sudan black B quenching method for specific immunofluorescence labelling.

    abstract:AIMS:High levels of autofluorescence in tissue samples can entirely mask specific labellings with fluorophores and thus impair immunofluorescence histochemistry. In pancreatic tissue samples we observed autofluorescence as a common problem often mediated by the fixation and processing procedure. METHODS AND RESULTS:Us...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12935

    authors: Erben T,Ossig R,Naim HY,Schnekenburger J

    更新日期:2016-09-01 00:00:00

  • Angiogenic potential of ductal carcinoma in situ (DCIS) of human breast.

    abstract:AIMS:Comedo carcinoma is generally regarded as the subtype of ductal carcinoma in situ (DCIS) most likely to progress to invasive carcinoma. Increased angiogenesis could be associated with an enhanced risk of progression and might therefore be a marker of poor prognosis, as can be demonstrated for invasive breast tumou...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2005.02299.x

    authors: Vogl G,Dietze O,Hauser-Kronberger C

    更新日期:2005-12-01 00:00:00

  • Non-endothelial KDR/flk-1 expression is associated with increased survival of patients with urothelial bladder carcinomas.

    abstract:AIMS:To investigate the immunohistochemical expression of KDR/flk-1 in a series of 114 urothelial bladder carcinomas in relation to clinicopathological parameters, Ki67, p53 and Bcl-2 protein expression and patient survival. KDR/flk-1 is a high-affinity tyrosine kinase receptor for vascular endothelial growth factor (V...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01690.x

    authors: Gakiopoulou-Givalou H,Nakopoulou L,Panayotopoulou EG,Zervas A,Mavrommatis J,Giannopoulos A

    更新日期:2003-09-01 00:00:00

  • What criteria reliably distinguish melanoma from benign melanocytic lesions?

    abstract::The differential diagnosis of melanocytic lesions is fraught with difficulty and a common source of litigation either if a lesion misreported as 'benign' recurs locally or re-presents with nodal metastases or if an atypical naevus is called 'malignant' leading to a cosmetically unsatisfactory wider resection, unwarran...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2000.01002.x

    authors: Okun MR,Edelstein LM,Kasznica J,Kirkham N,Slater DN

    更新日期:2000-11-01 00:00:00

  • DNA content in gallbladder carcinoma: a flow cytometric study of 96 cases.

    abstract::The DNA content in gallbladder carcinoma and its relation to histological and cytological features was studied in 79 primary gallbladder carcinomas and 16 metastases. Abnormal DNA content was observed in 48 (51%) of 95 cases. In primary carcinomas, 44 (55.6%) showed a diploid DNA content, and 35 (44.4%) were aneuploid...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1993.tb00495.x

    authors: Roa I,Araya JC,Shiraishi T,Yatani R,Wistuba I,Villaseca M,De Aretxabala X

    更新日期:1993-11-01 00:00:00

  • Stereological estimates of nuclear volume in carcinoma of the ampulla of Vater.

    abstract::The stereological estimate of mean nuclear volume is an objective and reproducible method of measurement of nuclear size in terms of absolute volume. We have used this method to study carcinomas of the ampulla of Vater. Our study includes 21 cases--five papillary and 16 intestinal--all treated by the same surgical pro...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1992.tb00382.x

    authors: Artacho-Perula E,Roldan-Villalobos R,Lopez-Rubio F,Vaamonde-Lemos R

    更新日期:1992-09-01 00:00:00

  • Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma.

    abstract:AIMS:Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remark...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14105

    authors: Bilecz A,Stockhammer P,Theegarten D,Kern I,Jakopovic M,Samarzija M,Klikovits T,Hoda MA,Döme B,Oberndorfer F,Muellauer L,Fillinger J,Kovács I,Pirker C,Schuler M,Plönes T,Aigner C,Klepetko W,Berger W,Brcic L,Laszlo

    更新日期:2020-07-01 00:00:00

  • Microscopical atrial amyloidosis in chronic heart disease.

    abstract::Nineteen out of 121 consecutive cardiac biopsies from 107 patients were found to contain amyloid deposits on routine Congo red screening. Seventeen were left atrial appendages removed during mitral valvotomy for chronic rheumatic mitral valve disease while the remaining two were right atrial appendages excised during ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1981.tb01828.x

    authors: Looi LM

    更新日期:1981-11-01 00:00:00

  • No evidence for c-erbB-2 overexpression in gastric carcinogenesis.

    abstract:AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1998.00376.x

    authors: Blok P,Craanen ME,Dekker W,Offerhaus GJ,Tytgat GN

    更新日期:1998-04-01 00:00:00