Overexpression of TNF-alpha and TNFRII in invasive micropapillary carcinoma of the breast: clinicopathological correlations.

Abstract:

AIMS:Angiogenesis is essential for tumour growth and metastasis and tumour necrosis factor (TNF)-alpha is a potent angiogenic factor. Invasive micropapillary carcinoma of the breast (IMPC), a rare subtype of breast cancer, possesses a lymphotropic nature with a high incidence of lymph node metastasis and poor prognosis. The aim was to evaluate the role of TNF-alpha and its receptor TNFRII in the vascular development and metastasis of IMPC. METHODS AND RESULTS:One hundred cases of IMPC and 97 cases of invasive ductal carcinoma, not otherwise specified (IDC) were studied in parallel by immunohistochemistry for TNF-alpha and TNFRII, and microvessel density (MVD) of the tumours was measured. The results showed that the expression of TNF-alpha and TNFRII and the MVD were higher in IMPC than in IDC (P < 0.05). In IMPC, MVD was significantly increased in those with lymph node metastasis compared with those without nodal metastasis (P = 0.001). TNF-alpha expression showed a significant positive correlation with the rate of proliferation, histological grade, lymph node metastasis and MVD (P < 0.05), whereas expression of TNFRII was correlated with TNF-alpha expression and the proliferation of tumour cells in IMPC (P < 0.05). CONCLUSIONS:Expression of TNF-alpha and TNFRII might play an important role in the angiogenesis, tumour cell proliferation and metastasis of IMPC. These markers could represent new targets for therapeutic intervention, i.e. blocking of TNF-alpha and its signal transduction could be a promising tool for treatment.

journal_name

Histopathology

journal_title

Histopathology

authors

Cui LF,Guo XJ,Wei J,Liu FF,Fan Y,Lang RG,Gu F,Zhang XM,Fu L

doi

10.1111/j.1365-2559.2008.03128.x

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

381-8

issue

4

eissn

0309-0167

issn

1365-2559

pii

HIS3128

journal_volume

53

pub_type

杂志文章
  • The normal parathyroid and the borderline with early hyperplasia: a light microscopic study.

    abstract::The light microscopical appearance of the normal parathyroid gland based on an autopsy study of 138 glands from 38 adults without evidence of hyperparathyroidism, is described. It differs from earlier descriptions in that we found less adipose tissue in the glands of many normal adults than had been reported. This obs...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1984.tb02353.x

    authors: Saffos RO,Rhatigan RM,Urgulu S

    更新日期:1984-05-01 00:00:00

  • Villous adenoma of the duodenum: cellular composition and histochemical findings.

    abstract::A villous adenoma of the duodenum was studied histologically and histochemically by semi-thin sections using glycol-methacrylate as embedding medium. All the four epithelial cell types which are present in normal duodenal mucosa (absorptive columnar, goblet, Paneth, endocrine) were found in the tumour, as well as undi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1982.tb02718.x

    authors: Mingazzini PL,Malchiodi Albedi F,Blandamura V

    更新日期:1982-03-01 00:00:00

  • Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association.

    abstract:AIMS:To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan and the association with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV). METHODS AND RESULTS:We investigated retrospectively 26 cases with a median age of 76.5. O...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13449

    authors: Chen BJ,Wang RC,Ho CH,Yuan CT,Huang WT,Yang SF,Hsieh PP,Yung YC,Lin SY,Hsu CF,Su YZ,Kuo CC,Chuang SS

    更新日期:2018-05-01 00:00:00

  • Quantification of extraprostatic extension in prostate cancer: different parameters correlated to biochemical recurrence after radical prostatectomy.

    abstract:AIMS:Different methods to substage extraprostatic extension (EPE) were correlated with biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS AND RESULTS:  A total of 157 consecutive RP specimens with EPE were completely embedded. Twenty-three patients with adjuvant therapy or detectable postoperative ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2011.03986.x

    authors: van Veggel BA,van Oort IM,Witjes JA,Kiemeney LA,Hulsbergen-van de Kaa CA

    更新日期:2011-10-01 00:00:00

  • HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category.

    abstract:AIMS:HER2 testing of invasive breast cancer by in-situ hybridization guides therapy decisions. Probing HER2 and centromere of chromosome 17 (cen17) simultaneously is supposed to reveal both a potential HER2 gene amplification and polysomy 17. However, a considerable number of breast cancer patients with quasi polysomy ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13253

    authors: Holzschuh MA,Czyz Z,Hauke S,Inwald EC,Polzer B,Brockhoff G

    更新日期:2017-10-01 00:00:00

  • CD30 expression in follicular lymphoma.

    abstract::The CD30 antigen is a characteristic phenotypic feature of Sternberg-Reed and Hodgkin cells and is also found in a subset of large cell non-Hodgkin's lymphomas. The finding of CD30 positive cells in some centroblastic/centrocytic (cb/cc) follicular lymphomas prompted us to characterize the presence and distribution of...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1991.tb00810.x

    authors: Piris M,Gatter KC,Mason DY

    更新日期:1991-01-01 00:00:00

  • Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy.

    abstract:AIMS:To characterize the histomorphological features of endometrial carcinomas (ECs) harbouring polymerase ε (POLE) mutations. METHODS AND RESULTS:Forty-three ECs with POLE mutations were compared with a cohort of 202 ECs. Most POLE-mutated ECs were endometrioid [34/43 (79%)]; the remaining tumours were mixed [6/43 (1...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12878

    authors: Bakhsh S,Kinloch M,Hoang LN,Soslow RA,Köbel M,Lee CH,McAlpine JN,McConechy MK,Gilks CB

    更新日期:2016-05-01 00:00:00

  • Cerebral ganglioglioma with anaplastic oligodendroglial component.

    abstract::We report an unusual and possibly unique example of cerebral ganglioglioma with an anaplastic oligodendroglial component. The latter was documented on both morphological and immunohistochemical grounds. Immunohistochemically, the anaplastic cells were strongly positive with the monoclonal antibody anti-Leu-7, while th...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb00765.x

    authors: Allegranza A,Pileri S,Frank G,Ferracini R

    更新日期:1990-11-01 00:00:00

  • Cutaneous ciliated cyst: a case report and immunohistochemical comparison with fallopian tube.

    abstract::An example of a cutaneous ciliated cyst in the buttock of a 42 year old woman is reported. The histological and immunohistochemical features of the cyst are presented: comparisons with fallopian tube are made and this rare lesion is discussed. ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb01165.x

    authors: al-Nafussi AI,Carder P

    更新日期:1990-06-01 00:00:00

  • Planimetry of the porta hepatis in biliary atresia.

    abstract:AIMS:Orientation and digital analysis of the biliary remnants in the resected porta hepatis in infants with biliary atresia. METHODS AND RESULTS:Samples were orientated intra-operatively then stained with haematoxylin and eosin and immunostained for cytokeratin 7 (CK7). Sections were then digitized and analysed. Most ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13028

    authors: Shalaby A,Hajhosseiny R,Zen Y,Davenport M,Quaglia A

    更新日期:2016-12-01 00:00:00

  • Vascular changes in radiation bowel disease.

    abstract::A series of 20 cases of radiation bowel disease (RBD) was studied qualitatively and the arterial changes were studied quantitatively. A control series of 45 cases was studied. In the control cases there were positive correlations between the medial thickness of all vessels studied and the diastolic blood pressure as w...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1985.tb02833.x

    authors: Hasleton PS,Carr N,Schofield PF

    更新日期:1985-05-01 00:00:00

  • Rhabdoid tumour of the bladder: a histological, ultrastructural and immunohistochemical study.

    abstract::A rapidly fatal bladder tumour which had the features of a rhabdoid tumour was studied by sequential biopsies and at autopsy. This is the first rhabdoid tumour recorded at this site and the first in which there was co-existent transitional cell carcinoma. The possibility that rhabdoid tumour is histogenetically hetero...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1987.tb01847.x

    authors: Harris M,Eyden BP,Joglekar VM

    更新日期:1987-10-01 00:00:00

  • Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma.

    abstract:AIMS:Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NP...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02920.x

    authors: Segawa Y,Oda Y,Yamamoto H,Uryu H,Shiratsuchi H,Hirakawa N,Tomita K,Yamamoto T,Oda S,Yamada T,Komune S,Tsuneyoshi M

    更新日期:2008-01-01 00:00:00

  • Aggressive B-cell lymphomas with a primary bone marrow presentation.

    abstract::Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B-cell lymphomas can be subdivided into entities that typically ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14124

    authors: Zamò A,Johnston P,Attygalle AD,Laurent C,Arber DA,Fend F

    更新日期:2020-09-01 00:00:00

  • Gastrointestinal lymphoproliferative disorders.

    abstract::Malignant lymphomas can be first detected in some patients in endoscopic biopsies of the gastrointestinal (GI) tract. However, their recognition and accurate classification often pose problems for the pathologist for several reasons. First, the small sampling size limits pattern recognition and the number of ancillary...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2006.02571.x

    authors: Banks PM

    更新日期:2007-01-01 00:00:00

  • Tumour regression grade (TRG) analyses in patients with resectable gastro-oesophageal adenocarcinomas treated with platinum-based neoadjuvant chemotherapy.

    abstract:AIMS:Neoadjuvant chemotherapy followed by surgery is the standard of care for patients with gastro-oesophageal adenocarcinoma. The aims were to validate the utility of the tumour regression grade (TRG) in patients who have received chemotherapy and to investigate if (i) TRG correlates with tumour downstaging and (ii) T...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2009.03404.x

    authors: Fareed KR,Ilyas M,Kaye PV,Soomro IN,Lobo DN,Parsons SL,Madhusudan S

    更新日期:2009-10-01 00:00:00

  • Value of long-core biopsy in the detection of discrete bone marrow lesions.

    abstract::A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1988.tb01988.x

    authors: Islam A,Henderson ES

    更新日期:1988-06-01 00:00:00

  • A study of vesical adenocarcinoma, intestinal metaplasia and related lesions using mucin histochemistry.

    abstract::Biopsy and autopsy material from the urinary bladder was studied using PAS and PAS-D techniques to identify glycogen and neutral mucins, the alcian blue/high iron diamine method to distinguish sialo- and sulphamucins and the PB/KOH/PAS technique to localize O-acylated sialomucins. All of 10 examples of normal urotheli...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb00711.x

    authors: Newbould M,McWilliam LJ

    更新日期:1990-09-01 00:00:00

  • Orthokeratinized odontogenic cyst: a clinicopathological and immunocytochemical study of 15 cases.

    abstract:AIMS:Intraosseous jaw cysts with a solely orthokeratinized lining epithelium have been suggested to differ from the typical odontogenic keratocysts (OKC) by exhibiting a less aggressive behaviour. We report 15 cases of such cyst type under the term of 'orthokeratinized odontogenic cyst (OOC)' and compared their clinica...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1998.00380.x

    authors: Li TJ,Kitano M,Chen XM,Itoh T,Kawashima K,Sugihara K,Nozoe E,Mimura T

    更新日期:1998-03-01 00:00:00

  • Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma.

    abstract:AIMS:Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in gallbladder tissues. I...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13797

    authors: Espinoza JA,Riquelme I,Sagredo EA,Rosa L,García P,Bizama C,Apud-Bell M,Leal P,Weber H,Benavente F,Vargas S,Romero D,Kalergis AM,Roa JC

    更新日期:2019-03-01 00:00:00

  • 'Atypical adenomatous hyperplasia' in liver cirrhosis: low-grade hepatocellular carcinoma or borderline lesion?

    abstract::Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes simila...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb00660.x

    authors: Nakanuma Y,Terada T,Terasaki S,Ueda K,Nonomura A,Kawahara E,Matsui O

    更新日期:1990-07-01 00:00:00

  • The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations.

    abstract::Anaplastic choroid plexus carcinoma is a tumour with a predilection for the posterior fossa of infants and can be difficult to distinguish histologically from medulloblastoma without the aid of immunocytochemistry using a panel of antibodies. Of a series of 17 choroid plexus carcinomas (five of which were classed as m...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1995.tb00643.x

    authors: Newbould MJ,Kelsey AM,Arango JC,Ironside JW,Birch J

    更新日期:1995-02-01 00:00:00

  • Pathological prognostic factors in locally advanced rectal carcinoma after neoadjuvant radiochemotherapy: analysis of 113 cases.

    abstract:AIMS:Neoadjuvant radiochemotherapy (RCT) followed by surgical resection is the treatment for locally advanced mid-rectal or low rectal cancer. The aim of this study was to evaluate postoperative histological prognostic factors in a series of surgical specimens after neoadjuvant RCT. METHODS AND RESULTS:One hundred and...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12432

    authors: Sannier A,Lefèvre JH,Panis Y,Cazals-Hatem D,Bedossa P,Guedj N

    更新日期:2014-11-01 00:00:00

  • Immunohistochemical characterization of prototypical endometrial clear cell carcinoma--diagnostic utility of HNF-1β and oestrogen receptor.

    abstract:AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12286

    authors: Hoang LN,Han G,McConechy M,Lau S,Chow C,Gilks CB,Huntsman DG,Köbel M,Lee CH

    更新日期:2014-03-01 00:00:00

  • The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma.

    abstract:AIMS:Macrophage colony-stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and stimulates proliferation and differentiation of monocytes, macrophages and their bone marrow progenitors. M-CSF, CSF-1R, the macrophage marker CD68, and the pan T-lymphocyte marker CD3 are increased in many huma...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2008.03058.x

    authors: Richardsen E,Uglehus RD,Due J,Busch C,Busund LT

    更新日期:2008-07-01 00:00:00

  • A UK NEQAS ICC and ISH multicentre study using the Kreatech Poseidon HER2 FISH probe: intersite variation can be rigorously controlled using FISH.

    abstract:AIM:To assess a new HER2 fluorescence in situ hybridization (FISH) test and report on multicentre intrasite and intersite variation. METHODS AND RESULTS:HER2 results were scored from 45 breast cancers in eight laboratories using the Kreatech Poseidon HER2 FISH probe (Kreatech Diagnostics, Amsterdam, the Netherlands). ...

    journal_title:Histopathology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2559.2010.03493.x

    authors: Bartlett JM,Campbell FM,Ibrahim M,Thomas J,Wencyk P,Ellis I,Kay E,Connolly Y,O'Grady A,Barnett S,Starczynski J,Cunningham P,Miller K

    更新日期:2010-02-01 00:00:00

  • Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation.

    abstract:BACKGROUND:Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare subtype of colorectal malignancy with expression of enteroblastic markers (glypican 3, SALL4, AFP); however, the clinicopathological and epidemiological features are not fully elucidated. AIMS:The aims of this study were to elucid...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14158

    authors: Yamashiro Y,Saito T,Hayashi T,Murakami T,Yanai Y,Tsuyama S,Suehara Y,Takamochi K,Yao T

    更新日期:2020-09-01 00:00:00

  • Post-transplant lymphoproliferative disorders: a morphologic, phenotypic and genotypic spectrum of disease.

    abstract::The post-transplant lymphoproliferative disorders represent a spectrum of life-threatening, generally Epstein-Barr virus-associated lymphoid proliferations which occur in the setting of exogenous immunosuppression following organ transplantation. Histopathological, phenotypic, genotypic and Epstein-Barr virus studies ...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.1992.tb01007.x

    authors: Swerdlow SH

    更新日期:1992-05-01 00:00:00

  • The renin-secreting cell in polyarteritis--an immunocytochemical study.

    abstract::We studied kidney sections from 15 cases of polyarteritis using an immunocytochemical technique to demonstrate cells containing immunoreactive renin. Ten cases of classical polyarteritis nodosa showed hyperplasia of renin-containing cells in areas of renal cortex with histological evidence of ischaemia--appearances in...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb01137.x

    authors: Graham PC,Lindop GB

    更新日期:1990-04-01 00:00:00

  • The immunoexpression of bcl-2 and p53 in Kaposi's sarcoma.

    abstract::The aim of this study was to examine the immunohistochemical expression of p53 and bcl-2 in Kaposi's sarcoma and relate this with proliferation index (as measured by MIB-1 staining) and clinicopathological subtypes. Twenty formalin-fixed, paraffin-embedded cases of Kaposi's sarcoma were stained with commercially avail...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1996.d01-493.x

    authors: Dada MA,Chetty R,Biddolph SC,Schneider JW,Gatter KC

    更新日期:1996-08-01 00:00:00