Pathological prognostic factors in locally advanced rectal carcinoma after neoadjuvant radiochemotherapy: analysis of 113 cases.

abstract：AIMS:Cluster of differentiation 103 (CD103), a marker of tissue resident memory T cells, is expressed on subsets of CD8+ T lymphocytes. We investigated the prognostic significance of CD103+ intra-epithelial tumour-infiltrating lymphocytes (iTILs) in invasive breast cancer (IBC). METHODS AND RESULTS:Immunohistochemistr...

journal_title：Histopathology

authors： Park MH,Kwon SY,Choi JE,Gong G,Bae YK

更新日期：2020-10-01 00:00:00

abstract：:Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils which are derived from different proteins in different forms of the disease. Asymptomatic amyloid deposition in a variety of tissues is a universal accompaniment of ageing, and clinical amyloidosis i...

journal_title：Histopathology

authors： Tan SY,Pepys MB

更新日期：1994-11-01 00:00:00

abstract：:Hairy leukoplakia is a recently described oral mucosal condition seen in immunosuppressed individuals, usually in association with HIV infection, when it is thought to be a sign of decreasing immunocompetence. It probably results from reactivation of infection by Epstein-Barr virus (EBV) and usually presents as bilate...

journal_title：Histopathology

authors： Southam JC,Felix DH,Wray D,Cubie HA

更新日期：1991-07-01 00:00:00

abstract：:Gonadoblastoma is defined as a neoplasm containing nests of germ cells and cells resembling Sertoli cells or granulosa cells. Gonadoblastomas arise almost exclusively in dysgenetic gonads. They are associated with an increased risk of developing germ cell tumours. Testicular germ cell tumours in adults are preceded by...

journal_title：Histopathology

authors： Jørgensen N,Müller J,Jaubert F,Clausen OP,Skakkebaek NE

更新日期：1997-02-01 00:00:00

abstract：AIMS:The morphological criteria for identification of intercalated duct lesions (IDLs) of salivary glands have been defined recently. It has been hypothesised that IDL could be a precursor of basal cell adenoma (BCA). BCAs show a variety of histological patterns, and the tubular variant is the one that presents the str...

journal_title：Histopathology

authors： Montalli VA,Martinez E,Tincani A,Martins A,Abreu Mdo C,Neves C,Costa AF,Araújo VC,Altemani A

更新日期：2014-05-01 00:00:00

abstract：:We present a 27-year-old woman with non-systemic diffuse lymphangiomatosis of spleen and liver. The tumour consisted of capillary and cavernous lymphatic vessels located in abundant fibrous tissue. The vascular endothelium showed immunoreactivity for factor VIII-related antigen. A basal lamina could be demonstrated im...

journal_title：Histopathology

authors： Schmid C,Beham A,Uranüs S,Melzer G,Auböck L,Seewann HL,Klimpfinger M

更新日期：1991-05-01 00:00:00

abstract：:Clinicopathological and immunohistological features of three cases of large cell lymphoma of bone are reported. On histological grounds, all the cases were diagnosed as histiocytic lymphomas (Rappaport) or primary centroblastic lymphomas, polymorphic subtype (Kiel). On immunophenotyping, malignant cells strongly react...

journal_title：Histopathology

authors： Falini B,Binazzi R,Pileri S,Mori A,Bertoni F,Canino S,Fagioli M,Minelli O,Ciani C,Pellicioli P

更新日期：1988-02-01 00:00:00

abstract：AIMS:Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci. METHODS AND RESULTS:Seventy-three CRCs with high-grade budding (> 10 budding foci in a x 20 objective field) were cl...

journal_title：Histopathology

authors： Shinto E,Mochizuki H,Ueno H,Matsubara O,Jass JR

更新日期：2005-07-01 00:00:00

abstract：:Ultrastructural appearances of a small intestinal inflammatory fibroid polyp are reported. There is a vascular scaffolding, with interstices which contain regular and fibrous long-spacing type collagen, condensed lamellar basement membrane fibroblasts, basophils, some eosinophils and histiocytes. In addition other cel...

journal_title：Histopathology

authors： Williams RM

更新日期：1981-03-01 00:00:00

abstract：:S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reaction...

journal_title：Histopathology

authors： Shaw PA,Fletcher A

更新日期：1991-02-01 00:00:00

abstract：AIMS:Hypoxia-inducible factor-1 (HIF-1) activity is regulated by prolyl hydroxylase (PHD1, PHD2, PHD3) and factor inhibiting HIF-1 (FIH) that target the α subunit of HIF-1 (HIF-1α) for proteosomal degradation. We hypothesised that the elevated HIF-1α level is due in some tumours to epigenetic silencing by DNA hypermeth...

journal_title：Histopathology

authors： Huang KT,Mikeska T,Dobrovic A,Fox SB

更新日期：2010-09-01 00:00:00

abstract：:Granular cell tumours rarely involve the lower respiratory tract. We report eight cases surgically resected at our institution. There were four females and four males, aged between 18 to 56 years (mean 40). One tumour associated with a peripheral lung adenocarcinoma was asymptomatic. The other lesions presented with o...

journal_title：Histopathology

authors： Thomas de Montpréville V,Dulmet EM

更新日期：1995-09-01 00:00:00

abstract：AIMS:HER2 testing of invasive breast cancer by in-situ hybridization guides therapy decisions. Probing HER2 and centromere of chromosome 17 (cen17) simultaneously is supposed to reveal both a potential HER2 gene amplification and polysomy 17. However, a considerable number of breast cancer patients with quasi polysomy ...

journal_title：Histopathology

authors： Holzschuh MA,Czyz Z,Hauke S,Inwald EC,Polzer B,Brockhoff G

更新日期：2017-10-01 00:00:00

abstract：:Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, in...

journal_title：Histopathology

authors： Wood KM,Cadogan MD,Ramshaw AL,Parums DV

更新日期：1993-05-01 00:00:00

abstract：AIMS:To compare the clinical and pathogenetic differences between high-grade (HG) endometrioid carcinomas with and without concurrent low-grade (LG) components. METHODS AND RESULTS:The expression of ARID1A, PTEN, p53 and mismatch repair (MMR) proteins in HG endometrioid carcinomas without (n = 19) or with (n = 22) con...

journal_title：Histopathology

authors： Mao TL,Ayhan A,Kuo KT,Lin MC,Tseng LH,Ogawa H

更新日期：2015-10-01 00:00:00

abstract：AIMS:There is controversy regarding the use of adjuvant therapy in patients with Dukes' B colorectal cancer (CRC). New markers, identifying high-risk Dukes' B patients, are needed. Here, we examine the utility of Raf kinase inhibitor protein (RKIP) as such a marker and promoter methylation as a mechanism of RKIP down-r...

journal_title：Histopathology

authors： Doyle B,Hagan S,Al-Mulla F,Scott L,Harden S,Paul J,Mulcahy H,Murray GI,Sheahan K,O'Sullivan J,Kolch W

更新日期：2013-02-01 00:00:00

abstract：AIM:Alveolar capillary dysplasia (ACD) is a rare disorder, typically presenting with persistent pulmonary hypertension of the newborn. The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome. METHODS AND RESULTS:Three pa...

journal_title：Histopathology

authors： Melly L,Sebire NJ,Malone M,Nicholson AG

更新日期：2008-10-01 00:00:00

abstract：AIMS:We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS:Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according...

journal_title：Histopathology

authors： Chan AC,Ho JW,Chiang AK,Srivastava G

更新日期：1999-01-01 00:00:00

abstract：:A variety of cytomorphological features, architectural patterns and stromal changes may be observed in malignant melanomas. Hence, melanomas may mimic carcinomas, sarcomas, benign stromal tumours, lymphomas, plasmacytomas and germ cell tumours. Melanomas may be composed of large pleomorphic cells, small cells, spindle...

journal_title：Histopathology

authors： Banerjee SS,Harris M

更新日期：2000-05-01 00:00:00

abstract：AIMS:Because of the clinical difficulty in identifying the early stages of human immunodeficiency virus (HIV) infection, the histopathologist often has to consider the diagnosis of HIV in tissue samples from patients with no previous suspicion of HIV infection. The aim was to investigate the practicality and utility of...

journal_title：Histopathology

authors： Moonim MT,Alarcon L,Freeman J,Mahadeva U,van der Walt JD,Lucas SB

更新日期：2010-03-01 00:00:00

abstract：:While the histological grade of a renal cell carcinoma is of prognostic significance there is poor concordance amongst pathologists in the use of these grading systems. Many grading systems have been described, but none has achieved widespread acceptance. The objective of this study was to assess the degree of interob...

journal_title：Histopathology

authors： Lanigan D,Conroy R,Barry-Walsh C,Loftus B,Royston D,Leader M

更新日期：1994-05-01 00:00:00

abstract：AIM:Achalasia is a disease of the oesophagus characterized by increased lower oesophageal sphincter (LOS) tone, absence of LOS relaxation with swallowing and aperistalsis of the body of the oesophagus. The aetiology and pathogenesis of idiopathic achalasia is still controversial. METHODS AND RESULTS:We examined 16 oes...

journal_title：Histopathology

authors： Raymond L,Lach B,Shamji FM

更新日期：1999-11-01 00:00:00

abstract：:Pulmonary typical carcinoid tumours are generally easy to diagnose with their uniform cells, carcinoid growth pattern and lack of mitoses. However, nuclear pleomorphism, which is common in other neuroendocrine tumours, is not emphasized in pulmonary carcinoid tumours. Three cases of typical carcinoid tumours, because ...

journal_title：Histopathology

authors： Sheppard MN

更新日期：1997-05-01 00:00:00

abstract：AIMS:Immune check-point inhibitors are known to cause immune-mediated adverse liver injury, but our knowledge is mainly based on cases treated with ipilimumab or nivolumab. METHODS AND RESULTS:Clinicopathological features of 10 patients with hepatobiliary adverse reactions caused by second-generation drugs, pembrolizu...

journal_title：Histopathology

authors： Zen Y,Chen YY,Jeng YM,Tsai HW,Yeh MM

更新日期：2020-02-01 00:00:00

abstract：:The distribution of epithelial L1 antigen was evaluated in 139 bronchogenic carcinomas which had been classified by a panel of pathologists according to the WHO recommendation of 1981. L1 was not found in three large cell and 13 small cell carcinomas, but it was expressed by tumour cells in 67 of 69 squamous cell carc...

journal_title：Histopathology

authors： Dale I,Brandtzaeg P

更新日期：1989-05-01 00:00:00

abstract：AIMS:Histological grade is one of the most important prognostic factors in breast carcinomas, but poorly differentiated neoplasms still have quite heterogeneous biological behaviour, since they can be genetically classified as basal-like, HER2+ or even luminal. The aim was to analyse the frequency of oestrogen receptor...

journal_title：Histopathology

authors： Fernandes RC,Bevilacqua JL,Soares IC,Siqueira SA,Pires L,Hegg R,Carvalho FM

更新日期：2009-09-01 00:00:00

abstract：AIMS:Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NP...

journal_title：Histopathology

authors： Segawa Y,Oda Y,Yamamoto H,Uryu H,Shiratsuchi H,Hirakawa N,Tomita K,Yamamoto T,Oda S,Yamada T,Komune S,Tsuneyoshi M

更新日期：2008-01-01 00:00:00

abstract：AIMS: Three histological variants of dysembryoplastic neuroepithelial tumour (DNT) have been described, namely, simple, complex and non-specific. However, the concept of non-specific variants of DNT remains controversial, because they cannot be accurately distinguished by histological findings alone from ordinary gliom...

journal_title：Histopathology

authors： Sung CO,Suh YL,Hong SC

更新日期：2011-08-01 00:00:00

abstract：:Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...

journal_title：Histopathology

authors： Simpson RH,Skálová A

更新日期：1997-01-01 00:00:00

abstract：:Fifteen hamartomas of the breast have been studied by dissecting microscopy of thick sections at a depth of 1.0 to 2.5 mm, and by conventional 5 microns deep sections. This combined approach has revealed six distinctive features, three in the parenchymal structure and three in the connective tissue components. Ducts (...

journal_title：Histopathology

authors： Davies JD,Kulka J,Mumford AD,Armstrong JS,Wells CA

更新日期：1994-02-01 00:00:00