解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS:Atypical polypoid adenomyoma (APAM) is an uncommon uterine lesion composed of complex endometrioid glands with frequent squamous morular metaplasia and fibromuscular stroma. On endometrial curettage, biopsy, or polypectomy specimens, the admixture of endometrioid glands and smooth muscle raises the differential di...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14338
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14331
更新日期:2021-01-10 00:00:00
abstract:AIMS:Hepatocellular adenoma is an uncommon liver neoplasm and the studies of HCA subtypes have been primarily limited to France, United States and Japan. We aimed to describe the clinicopathologic features of hepatocellular adenoma subtypes in Turkey. METHODS AND RESULTS:The resection specimens of 59 cases diagnosed a...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14330
更新日期:2021-01-06 00:00:00
abstract:AIMS:Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterized by malignant transformation of a pre-existing benign trichoblastoma and subdivided histologically into low- and high-grade tumours. While morphologically low-grade trichoblastic carcinomas show an indolent b...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14325
更新日期:2021-01-03 00:00:00
abstract::Neuroendocrine neoplasms (NENs) of the gastrointestinal tract (GIT) comprise neuroendocrine tumours (NETs) and neuroendocrine carcinomas (NECs). During the last decade the classification and grading of GIT NENs has undergone significant changes, culminating in the World Health Organisation (WHO) 2019 classification. T...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14172
更新日期:2021-01-01 00:00:00
abstract:AIMS:Pseudosarcomatous myofibroblastic proliferations (PSMPs) of the urinary bladder are diagnostically challenging. Diagnostic difficulties are mainly due to frequent cytokeratin expression, variable ALK expression and worrisome morphological features suggestive of malignancy. Conversely, sarcomatoid urothelial carcin...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14206
更新日期:2020-12-01 00:00:00
abstract::To our knowledge, the in situ phase of small cell lung carcinoma (SCLC) has not been reported previously although in situ/pre-invasive lesions are commonly observed in murine models. We report a patient diagnosed with SCLC presenting mostly as carcinoma in situ after photodynamic therapy (PDT) under the diagnosis of b...
journal_title:Histopathology
pub_type: 信件
doi:10.1111/his.14308
更新日期:2020-11-30 00:00:00
abstract:AIMS:NUT carcinoma, a rare aggressive tumor driven by NUTM1 rearrangements, often involves the lung/mediastinum and shows squamous differentiation. We encountered an index patient with a thoracic NUT carcinoma diagnosed by molecular testing, demonstrating extensive pleural involvement and diffuse TTF-1 expressions init...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14306
更新日期:2020-11-24 00:00:00
abstract:AIMS:Tumour-infiltrating lymphocytes (TILs) are prognostic in invasive breast cancer; however, their prognostic significance in ductal carcinoma in situ (DCIS) has not been established. The Oncotype DX (ODX) Breast DCIS Score test is a genomic assay used to predict the local recurrence risk. The aims of this study were...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14181
更新日期:2020-11-01 00:00:00
abstract:AIMS:NTRK gene rearranged sarcomas are emerging as a distinct class of sarcomas of particular importance in the era of targeted therapy. In this study we used Array Comparative Genomic Hybridisation (aCGH) to explore the cytogenetic profile of 6 adult soft tissue sarcomas harbouring NTRK gene fusions. METHODS AND RESU...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14295
更新日期:2020-10-31 00:00:00
abstract:AIMS:MYC is a proto-oncogene that is frequently dysregulated in various malignancies, through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification, and immunohistochemical expression has been shown to be a reliable surrogate marker for amplification, but less is known abo...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14168
更新日期:2020-10-01 00:00:00
abstract:AIMS:Cluster of differentiation 103 (CD103), a marker of tissue resident memory T cells, is expressed on subsets of CD8+ T lymphocytes. We investigated the prognostic significance of CD103+ intra-epithelial tumour-infiltrating lymphocytes (iTILs) in invasive breast cancer (IBC). METHODS AND RESULTS:Immunohistochemistr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14126
更新日期:2020-10-01 00:00:00
abstract::Tumour budding in colorectal cancer, defined as single tumour cells or small clusters containing four or fewer tumour cells, is a robust and independent biomarker of aggressive tumour biology. On the basis of published data in the literature, the evidence is certainly in favour of reporting tumour budding in routine p...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.14267
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:We describe cytologic and immunohistologic findings in virus transport medium on cases under investigation of SARS-CoV-2 infection. METHODS:Cytologic findings in cases under investigation of SARS-CoV-2 infection from one hundred consecutive nasopharyngeal swab were reviewed. Immunohistochemistry and SARSC...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14257
更新日期:2020-09-24 00:00:00
abstract:AIMS:Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14254
更新日期:2020-09-16 00:00:00
abstract:AIMS:Secretory carcinoma (SC) (synonym: mammary analogue secretory carcinoma) is a low-grade salivary gland tumour that occurs in both major and minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, which overlaps with those of several salivary gland neoplasms, i...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14251
更新日期:2020-09-15 00:00:00
abstract::Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B-cell lymphomas can be subdivided into entities that typically ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14124
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare subtype of colorectal malignancy with expression of enteroblastic markers (glypican 3, SALL4, AFP); however, the clinicopathological and epidemiological features are not fully elucidated. AIMS:The aims of this study were to elucid...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14158
更新日期:2020-09-01 00:00:00
abstract:AIMS:Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histol...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14114
更新日期:2020-08-01 00:00:00
abstract:AIMS:Perineural invasion (PNI) by prostatic adenocarcinoma is debated as a prognostic parameter. This study investigates the prognostic predictive value of PNI in a series of patients with locally advanced prostate cancer treated with radiotherapy and androgen deprivation using 10 years outcome data from the TROG 03.04...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14107
更新日期:2020-08-01 00:00:00
abstract:AIMS:Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remark...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14105
更新日期:2020-07-01 00:00:00
abstract:AIMS:Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland carcinomas. Epidermal growth factor receptor (EGFR) signalling pathway gene mutations are important in predicting a patient's prognosis, selecting molecularly targeted drugs and estimating the efficacy of a molecular therapy. However, their si...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14100
更新日期:2020-06-01 00:00:00
abstract:AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14103
更新日期:2020-06-01 00:00:00
abstract:AIMS:The clinical significance of common histological parameters in acute interstitial nephritis (AIN) is uncertain. We aimed to evaluate the utility of histology in predicting clinical outcomes in patients with AIN. METHODS AND RESULTS:Adult renal biopsies yielding a diagnosis of AIN between 2000 and 2015 were re-exa...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14031
更新日期:2020-04-01 00:00:00
abstract:AIMS:BCOR gene alteration is a genetic signature of rare subsets of sarcomas. Most BCOR-associated sarcomas thus far reported are in the pediatric population, except for uterine sarcomas. We studied seven cases of BCOR-associated non-uterine sarcomas in adult patients. METHODS AND RESULTS:The patients were four men an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14023
更新日期:2020-03-01 00:00:00
abstract:AIMS:Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is caused by germline mutations in the Fumarate hydratase (FH) gene. In young women, the syndrome often presents with symptomatic uterine leiomyomas, leading to myomectomy or hysterectomy. In this study, we aimed to investigate the incidence and muta...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14007
更新日期:2020-02-01 00:00:00
abstract:AIMS:Immune check-point inhibitors are known to cause immune-mediated adverse liver injury, but our knowledge is mainly based on cases treated with ipilimumab or nivolumab. METHODS AND RESULTS:Clinicopathological features of 10 patients with hepatobiliary adverse reactions caused by second-generation drugs, pembrolizu...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14000
更新日期:2020-02-01 00:00:00
abstract:AIMS:Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare malignancy, and its clinicopathological characteristics have not yet been fully elucidated. This study aimed to elucidate the clinicopathological features of CAED through immunostaining of enteroblastic lineage markers alpha-fetoprotein ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13973
更新日期:2020-01-01 00:00:00
abstract:AIMS:Patients with aggressive CD8+ cutaneous T-cell lymphomas (CTCLs) progress rapidly and respond poorly to therapy. Confounding treatment planning, there is clinicopathological overlap between aggressive CD8+ CTCLs and other lymphoproliferative disorders (LPDs). Hence, improved diagnostic methods and therapeutic opti...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13960
更新日期:2020-01-01 00:00:00
abstract:AIMS:Despite increasing interest in the recently established immunoglobulin 4-related disease (IgG4-RD), its pathogenesis and aetiology remain largely unclear. Characteristic histopathological features are one of the key elements of diagnosis, including 'storiform' fibrosis, obliterative phlebitis, increased lymphoplas...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13965
更新日期:2020-01-01 00:00:00
abstract::The treatment of cancer has changed dramatically over the last decade, driven by increased understanding of the cancer genome, immune landscape, molecular alterations and aberrant pathways that drive cancer progression. Advances in molecular biology have led to the development of targeted agents, including monoclonal ...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.14009
更新日期:2020-01-01 00:00:00
abstract:AIMS:Pulmonary chondromas, which are rare cartilaginous neoplasms that often arise in the setting of Carney triad, are morphologically similar to pulmonary hamartomas, which are much more common. There is evidence that succinate dehydrogenase (SDH) deficiency drives neoplasia in patients with Carney triad, and SDHB imm...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13945
更新日期:2019-12-01 00:00:00
abstract:AIMS:Clear cell chondrosarcomas are known to occasionally contain areas of low-grade conventional chondrosarcoma; however, the opposite phenomenon has not yet been described. We identified five cases of conventional chondrosarcoma alongside clear cell chondrosarcoma. Here, we report on their clinicopathological and mol...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13952
更新日期:2019-12-01 00:00:00
abstract:AIMS:Segmental atrophy (SA) of the liver is a recently described pseudotumour that can show a broad spectrum of histological changes. The previously described histological differential diagnosis of SA has included cystic disease of the liver, amyloid, cancer-associated elastosis, and epithelioid haemangioendothelioma. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13961
更新日期:2019-12-01 00:00:00
abstract:AIMS:To characterise the mutational profiles of poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) and to identify markers with potential diagnostic, prognostic and therapeutic significance. METHODS AND RESULTS:Targeted next-generation sequencing with a panel of 18 thyroid carcinoma-...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13942
更新日期:2019-12-01 00:00:00
abstract:AIMS:Thymic carcinoma is rare and usually has a fatal outcome. Gene mutations in the epidermal growth factor receptor (EGFR) signalling pathway and TP53 have not been well analysed in thymic carcinoma. METHODS AND RESULTS:We examined a large cohort of thymic carcinoma and thymoma type A/B3 and looked for gene mutation...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13936
更新日期:2019-11-01 00:00:00
abstract::The introduction of fast and robust whole slide scanners has facilitated the implementation of 'digital pathology' with various uses, the final challenge being full digital diagnostics. In this article, we describe the implementation process of a fully digital workflow for primary diagnostics in 2015 at the University...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13953
更新日期:2019-11-01 00:00:00
abstract:AIMS:To discern the differences in expression profiling of two histological subtypes of colorectal carcinoma (CRC) arising from the serrated route (serrated adenocarcinoma (SAC) and CRC showing histological and molecular features of a high level of microsatellite instability (hmMSI-H) both sharing common features (fema...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13889
更新日期:2019-10-01 00:00:00
abstract::The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, ...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13877
更新日期:2019-10-01 00:00:00
abstract:AIMS:The B7 family check-point molecules are potential therapeutic targets in cancer immunotherapy. However, their expression status in human gestational trophoblastic neoplasia (GTN) remains unknown. We investigated the expression profiles of the B7 family check-point proteins PD-L1, PD-L2, B7-H3, B7-H4, VISTA and B7-...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13882
更新日期:2019-09-01 00:00:00