Abstract:
AIMS:Cluster of differentiation 103 (CD103), a marker of tissue resident memory T cells, is expressed on subsets of CD8+ T lymphocytes. We investigated the prognostic significance of CD103+ intra-epithelial tumour-infiltrating lymphocytes (iTILs) in invasive breast cancer (IBC). METHODS AND RESULTS:Immunohistochemistry was performed for CD103, CD8 and TGF-β isoforms (1, 2 and 3) on tissue microarrays of 1187 IBC samples. CD103+ and CD8+ iTILs were present in 904 (76.2%) and 854 (74%) cases with an overall mean ± standard deviation of 38.2 ± 100.2/mm2 and 30.4 ± 89.7/mm2 , respectively. The numbers of CD103+ and CD8+ iTILs were positively correlated, and CD103+ iTILs outnumbered CD8+ iTILs in HER2-positive and triple-negative breast cancer (TNBC). CD103+ and CD8+ iTIL densities were significantly higher in tumours of histological grade 3, absence of lymphovascular invasion, high Ki-67 index, high stromal TIL density or TGF-β3 expression. High CD103+ iTIL density was associated with better disease-free survival (DFS, P = 0.007), but no significant association was observed for overall survival (OS). Subgroup analysis by cancer molecular subtype showed that CD103+ iTIL count was prognostic only for TNBC (OS, P = 0.035; DFS, P = 0.009). CD8+ iTIL density was significant for DFS, but not for OS, in the entire cohort and TNBC. In multivariate analysis, CD103+ iTIL density was an independent prognostic factor of OS (P = 0.02) and DFS (P = 0.007) in TNBC, while CD8+ iTIL density was not significant for survival. CONCLUSIONS:CD103 iTIL density can serve as a predictor of good prognosis in patients with TNBC.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Park MH,Kwon SY,Choi JE,Gong G,Bae YKdoi
10.1111/his.14126subject
Has Abstractpub_date
2020-10-01 00:00:00pages
560-569issue
4eissn
0309-0167issn
1365-2559journal_volume
77pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract::Chromosomal rearrangements resulting in the fusion of coding parts from two genes or in the exchange of regulatory sequences are present in approximately 20% of all human neoplasms. More than 1000 such gene fusions have now been described, with close to 100 of them in soft tissue tumours. Although little is still know...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12272
更新日期:2014-01-01 00:00:00
abstract::A variety of cytomorphological features, architectural patterns and stromal changes may be observed in malignant melanomas. Hence, melanomas may mimic carcinomas, sarcomas, benign stromal tumours, lymphomas, plasmacytomas and germ cell tumours. Melanomas may be composed of large pleomorphic cells, small cells, spindle...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.2000.00894.x
更新日期:2000-05-01 00:00:00
abstract:AIM:To describe a group of distinct low-grade oncocytic renal tumours that demonstrate CD117 negative/cytokeratin (CK) 7-positive immunoprofile. METHODS AND RESULTS:We identified 28 such tumours from four large renal tumour archives. We performed immunohistochemistry for: CK7, CD117, PAX8, CD10, AMACR, e-cadherin, CK2...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13865
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14331
更新日期:2021-01-10 00:00:00
abstract:AIMS:In skull base chordoma, c-MET expression has been reported to correlate with younger patient age and favourable prognosis; however, it also contributes to tumour invasiveness, especially in recurrent lesions, suggesting variable roles for c-MET according to clinical status. The aim of this study was to investigate...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03278.x
更新日期:2009-04-01 00:00:00
abstract:AIMS:To ascertain the prognostic relevance of micropapillary carcinoma, a specific type of breast tumour. METHODS AND RESULTS:We interrogated the clinical records of a series of 49 pure micropapillary carcinoma patients and 13 487 invasive ductal carcinoma patients, diagnosed and treated consecutively in our instituti...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12147
更新日期:2013-08-01 00:00:00
abstract::Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes simila...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb00660.x
更新日期:1990-07-01 00:00:00
abstract:AIMS:Glutamate receptor antagonists have failed clinical stroke trials and it has been proposed that the action of N-methyl D-aspartate receptors is necessary for neuronal survival. Thus, excitatory amino acid transporters (EAATs) might be a promising therapeutic target. The aim of this study was to investigate glial e...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02703.x
更新日期:2007-06-01 00:00:00
abstract:AIMS:Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14254
更新日期:2020-09-16 00:00:00
abstract:AIMS:To document the clinical, light microscopic, immunohistochemical and ultrastructural features of four cases of extra-orbital giant cell angiofibromas. METHODS AND RESULTS:Sections of formalin-fixed paraffin-embedded specimens were studied by haematoxylin and eosin, reticulin and immunohistochemical stains. Electr...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.2001.01227.x
更新日期:2001-10-01 00:00:00
abstract:AIMS:The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent a precursor of more aggressive forms of disease. METHODS AND RESULTS:A 59-year-old man with diffuse cutaneous reticulohistiocytosis experienced bone marrow locali...
journal_title:Histopathology
pub_type:
doi:10.1111/his.13166
更新日期:2017-05-01 00:00:00
abstract:AIMS:Five cases of a characteristic low-grade thymic epithelial tumour are described that we suggest calling metaplastic carcinoma of the thymus. METHODS AND RESULTS:The patients' ages ranged from 44 to 71 (mean 56.2) years. Four of the patients were male. Three of five tumours showed invasion into mediastinal fat or ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00691.x
更新日期:1999-07-01 00:00:00
abstract::Three cases are reported in which an initial diagnosis of the plasma cell variant of Castleman's disease was made, but in which a second lymph node biopsy within a year showed evidence of Hodgkin's disease. Review of the initial biopsy indicated that atypical CD15 and CD30 positive cells were present in the initial bi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00833.x
更新日期:1991-03-01 00:00:00
abstract::Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01574.x
更新日期:1994-08-01 00:00:00
abstract::Calcitonin is a hypocalcaemia producing hormone and is secreted by C-cells of the thyroid. The current study was undertaken on a hypothesis that C-cell hyperplasia may develop in the secondary hyperparathyroidism of chronic renal failure in response to sustained hypercalcaemia. With an immunoperoxidase staining method...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00433.x
更新日期:1992-11-01 00:00:00
abstract:AIMS:Lung cancer patients within the pN0 category have a significantly different outcome. The aim of this study was to develop a mathematical model to assist in predicting the prognosis of pN0 lung squamous cell carcinoma (SCC). METHODS AND RESULTS:Twenty-three proteins were examined by immunohistochemical (IHC) analy...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2011.04013.x
更新日期:2011-11-01 00:00:00
abstract::The relationship between proliferating cell nuclear antigen (PCNA) expression and various clinicopathological indices (age, sex, tumour location, histological type and grade and treatment) and post-operative survival were studied in patients with central nervous system gliomas using univariate and multivariate analysi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01353.x
更新日期:1994-10-01 00:00:00
abstract:AIMS:Recent analyses have suggested that Hodgkin's or Reed-Sternberg (HRS) cells in most cases of classic Hodgkin's disease are derived from germinal centre B-cells. However, there is controversy over which B-cell antigens are expressed in HRS cells. METHODS AND RESULTS:We studied 51 cases of classic Hodgkin's disease...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00830.x
更新日期:2000-04-01 00:00:00
abstract::We investigated the expression of androgen receptor (AR) protein in transitional cell carcinoma of human urinary bladder in paraffin-embedded sections of tumours obtained from nine patients with urinary bladder cancer treated by radical cystectomy. In addition, immunoblotting of AR was also performed on selected sampl...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.5610801.x
更新日期:1997-06-01 00:00:00
abstract:AIMS:Intestinal metaplasia is considered to be a precursor lesion in both Barrett's and intestinal-type gastric cancer. The aim was to clarify the differences in molecular pathology between specialized intestinal metaplasia (SIM) in Barrett's oesophagus (BO), cardiac (CIM) and gastric intestinal metaplasia (GIM). METH...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03370.x
更新日期:2009-09-01 00:00:00
abstract:AIMS:Conjunctival pigmented lesions have characteristic clinical and histopathological appearances. Melanocytic pigmented lesions commonly occur in the conjunctiva, although they have not been previously reported in pterygium, a common lesion which originates from conjunctiva. Our aim was to evaluate the possibility of...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2006.02346.x
更新日期:2006-03-01 00:00:00
abstract:AIMS:Merkel cell carcinoma represents poorly differentiated neuroendocrine carcinoma of cutaneous origin. In most studies, the vast majority of Merkel cell carcinomas are Merkel cell polyomavirus (MCPyV)-associated. SV40 polyomavirus immunohistochemistry is typically used in the diagnosis of other polyomavirus-associat...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13483
更新日期:2018-07-01 00:00:00
abstract:AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12286
更新日期:2014-03-01 00:00:00
abstract:AIMS:Despite increasing interest in the recently established immunoglobulin 4-related disease (IgG4-RD), its pathogenesis and aetiology remain largely unclear. Characteristic histopathological features are one of the key elements of diagnosis, including 'storiform' fibrosis, obliterative phlebitis, increased lymphoplas...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13965
更新日期:2020-01-01 00:00:00
abstract:AIMS:To examine the expression of the Bcl-2 family of proteins (Bcl-2, Bcl-x, Bcl-xL and Bax) in classical Hodgkin's lymphoma (cHL) and to correlate the expression of these proteins with proliferation, apoptosis and the presence of Epstein-Barr virus (EBV). METHODS AND RESULTS:Expression of the Bcl-2 family of protein...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.0309-0167.2004.01829.x
更新日期:2004-03-01 00:00:00
abstract:AIMS:Calcific aortic stenosis is a progressive disease characterized by massive fibrosis andmineralization of the valve leaflets. The aim of this study was to determine whether the onset of native calcific aortic stenosis is associated primarily with matrix remodelling events, and particularly with elastin degradation....
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.2011.03977.x
更新日期:2011-09-01 00:00:00
abstract::Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging sy...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.2011.04025.x
更新日期:2012-01-01 00:00:00
abstract:AIMS:BCOR gene alteration is a genetic signature of rare subsets of sarcomas. Most BCOR-associated sarcomas thus far reported are in the pediatric population, except for uterine sarcomas. We studied seven cases of BCOR-associated non-uterine sarcomas in adult patients. METHODS AND RESULTS:The patients were four men an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14023
更新日期:2020-03-01 00:00:00
abstract:AIMS:To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes. METHODS AND RESULTS:RAD51 expression identified immunohistochemically was compared between prostatic cancers occ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03448.x
更新日期:2009-12-01 00:00:00
abstract:AIMS:Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland carcinomas. Epidermal growth factor receptor (EGFR) signalling pathway gene mutations are important in predicting a patient's prognosis, selecting molecularly targeted drugs and estimating the efficacy of a molecular therapy. However, their si...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14100
更新日期:2020-06-01 00:00:00