Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma.

abstract：AIMS:To ascertain the prognostic relevance of micropapillary carcinoma, a specific type of breast tumour. METHODS AND RESULTS:We interrogated the clinical records of a series of 49 pure micropapillary carcinoma patients and 13 487 invasive ductal carcinoma patients, diagnosed and treated consecutively in our instituti...

journal_title：Histopathology

authors： Vingiani A,Maisonneuve P,Dell'orto P,Farante G,Rotmensz N,Lissidini G,Del Castillo A,Renne G,Luini A,Colleoni M,Viale G,Pruneri G

更新日期：2013-08-01 00:00:00

abstract：:Cytokeratin antibodies have been widely used for the identification of trophoblast cells in the placental bed, following their invasion from the developing conceptus. Their identification centres upon the expression of cytokeratin in epithelial cells, from which trophoblast cells are derived. Our recent observations i...

journal_title：Histopathology

authors： Stiemer B,Graf R,Neudeck H,Hildebrandt R,Hopp H,Weitzel HK

更新日期：1995-11-01 00:00:00

abstract：:In the Cambridge renal transplant unit percutaneous needle biopsies of renal transplants have been extensively used to help identify the cause of impaired allograft function. During the period 1966--1973, 154 of the 269 renal allografts transplanted were biopsied at least once during the first 90 days after transplant...

journal_title：Histopathology

authors： Herbertson BM,Evans DB,Calne RY,Banerjee AK

更新日期：1977-05-01 00:00:00

abstract：:A case of squamous cell carcinoma of the lung showing extensive spindle transformation is presented. On light microscopy, the tumour showed sheets and fascicles of elongated fusiform cells resulting in a growth pattern which closely resembled a sarcoma. Immunocytochemistry using tissue-specific antibodies against inte...

journal_title：Histopathology

authors： Suster S,Huszar M,Herczeg E

更新日期：1987-08-01 00:00:00

abstract：:Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...

journal_title：Histopathology

authors： Simpson RH,Skálová A

更新日期：1997-01-01 00:00:00

abstract：AIMS:Fibroadenomas (FAs) and phyllodes tumours (PTs) are fibroepithelial tumours. Mutations in MED12 exon 2 have been reported in FAs. This study investigated the MED12 mutations in a spectrum of fibroepithelial tumours. METHODS AND RESULTS:Using direct sequencing, we analysed MED12 exon 2 mutations on 121 samples, in...

journal_title：Histopathology

authors： Lien HC,Huang CS,Yang YW,Jeng YM

更新日期：2016-02-01 00:00:00

abstract：AIMS:The staining pattern of the recently described antibody melan-A was compared with those of S100 protein and HMB-45 in a variety of melanocytic lesions to assess the specificity and sensitivity of these antibodies. METHODS AND RESULTS:Immunohistochemical staining of paraffin sections of a range of melanocytic lesi...

journal_title：Histopathology

authors： Blessing K,Sanders DS,Grant JJ

更新日期：1998-02-01 00:00:00

abstract：AIMS:We report a case study to elucidate the pathogenesis of polyarteritis nodosa (PAN) type vasculitis, a rare complication of familial mediterranean fever (FMF). METHODS AND RESULTS:A woman with amyloidosis complicating FMF underwent a cadaveric renal transplantation and 5 years later suffered an acute myocardial in...

journal_title：Histopathology

authors： Serrano R,Martínez MA,Andrés A,Morales JM,Samartin R

更新日期：1998-08-01 00:00:00

abstract：:A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...

journal_title：Histopathology

authors： Islam A,Henderson ES

更新日期：1988-06-01 00:00:00

abstract：:Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging sy...

journal_title：Histopathology

authors： Cheng L,Montironi R,Bostwick DG,Lopez-Beltran A,Berney DM

更新日期：2012-01-01 00:00:00

abstract：:Low grade fibromyxoid sarcoma is a recently recognized, uncommon soft tissue neoplasm with a tendency to develop in deep soft tissue of young adults. Diagnostic criteria have not been well defined and this tumour has not been widely accepted as a distinct entity. Eleven new cases are reported here for which reproducib...

journal_title：Histopathology

authors： Goodlad JR,Mentzel T,Fletcher CD

更新日期：1995-03-01 00:00:00

abstract：:A 76-year-old man with lymphoma involving cervical and mediastinal lymph nodes and abdomen was treated by radiotherapy and chemotherapy. He subsequently developed cytomegalovirus gastritis and gastric ulcers with a gastrocolic fistula and a jejuno-jejunal fistula, necessitating a partial gastrectomy. The pathogenesis ...

journal_title：Histopathology

authors： Aqel NM,Tanner P,Drury A,Francis ND,Henry K

更新日期：1991-02-01 00:00:00

abstract：AIMS:Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of BAP1 and EZH2 in malignant mes...

journal_title：Histopathology

authors： Shinozaki-Ushiku A,Ushiku T,Morita S,Anraku M,Nakajima J,Fukayama M

更新日期：2017-04-01 00:00:00

abstract：AIMS:We sought to delineate and describe three cases of a distinctive mesenchymal neoplasm of the vulva showing adipocytic differentiation and affecting young patients. METHODS AND RESULTS:In three patients between 13 and 38 years of age, the vulvar tumours had well-circumscribed borders and ranged in size from 35 to ...

journal_title：Histopathology

authors： Lae ME,Pereira PF,Keeney GL,Nascimento AG

更新日期：2002-06-01 00:00:00

abstract：AIMS:Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis-meiosis transition in order to define the antigen profile for diagnostic purposes and to clarify the biolo...

journal_title：Histopathology

authors： Rajpert-De Meyts E,Jacobsen GK,Bartkova J,Aubry F,Samson M,Bartek J,Skakkebaek NE

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...

journal_title：Histopathology

authors： Badr NM,Spooner D,Steven J,Stevens A,Shaaban AM

更新日期：2021-01-10 00:00:00

abstract：AIMS:To validate the use of the silver-enhanced in situ hybridization (SISH) technique in assessing HER2 status of breast carcinoma in excision biopsy specimens, and to assess its reliability in determining HER2 status in core biopsy specimens. METHODS AND RESULTS:Routinely processed paraffin sections of 65 excised br...

journal_title：Histopathology

authors： Shousha S,Peston D,Amo-Takyi B,Morgan M,Jasani B

更新日期：2009-01-01 00:00:00

abstract：:The benign 'Triton' tumour is a neural tumour with benign rhabdomyomatous differentiation: it must be distinguished from the better known malignant counterpart. We describe the first case outside the peripheral soft tissues and the first to be studied ultrastructurally. It also represents the second lesion identified ...

journal_title：Histopathology

authors： Azzopardi JG,Eusebi V,Tison V,Betts CM

更新日期：1983-07-01 00:00:00

abstract：AIMS:Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare malignancy, and its clinicopathological characteristics have not yet been fully elucidated. This study aimed to elucidate the clinicopathological features of CAED through immunostaining of enteroblastic lineage markers alpha-fetoprotein ...

journal_title：Histopathology

authors： Murakami T,Yao T,Yatagai N,Yamashiro Y,Saito T,Sakamoto N,Nagahara A

更新日期：2020-01-01 00:00:00

abstract：AIMS:Perineural invasion (PNI) by prostatic adenocarcinoma is debated as a prognostic parameter. This study investigates the prognostic predictive value of PNI in a series of patients with locally advanced prostate cancer treated with radiotherapy and androgen deprivation using 10 years outcome data from the TROG 03.04...

journal_title：Histopathology

authors： Delahunt B,Murray JD,Steigler A,Atkinson C,Christie D,Duchesne G,Egevad L,Joseph D,Matthews J,Oldmeadow C,Samaratunga H,Spry NA,Srigley JR,Hondermarck H,Denham JW

更新日期：2020-08-01 00:00:00

abstract：:Several malignant tumours occurring in the sinonasal tract may present with an undifferentiated morphology. Overall, these lesions pose significant diagnostic difficulties for the surgical pathologist, especially in limited biopsy material, but their correct classification is becoming increasingly important for an app...

journal_title：Histopathology

authors： Franchi A,Palomba A,Cardesa A

更新日期：2011-12-01 00:00:00

abstract：AIMS:Tyrosine kinase receptors Her2/neu and c-Met play an important role in breast cancer development and progression. Our aim was to determine the expression of c-Met, its ligand hepatocyte growth factor/scatter factor (HGF/SF) and Her2/neu in ductal carcinoma in situ (DCIS) lesions of the breast (n = 39) by two diffe...

journal_title：Histopathology

authors： Lindemann K,Resau J,Nährig J,Kort E,Leeser B,Annecke K,Welk A,Schäfer J,Vande Woude GF,Lengyel E,Harbeck N

更新日期：2007-07-01 00:00:00

abstract：AIMS:To characterize the clinicopathological features and biological potential of a group of soft tissue lesions with morphology intermediate between intramuscular myxoma and low-grade myxofibrosarcoma. METHODS AND RESULTS:Thirty-eight lesions in 37 patients were retrieved from the authors' consultation files. Clinica...

journal_title：Histopathology

authors： van Roggen JF,McMenamin ME,Fletcher CD

更新日期：2001-09-01 00:00:00

abstract：AIMS:Intestinal metaplasia (IM) has been implicated in the pathogenesis of gastro-oesophageal carcinoma, but because of its common occurrence, its specificity for use in cancer surveillance is low. IM subtypes characterized by mucin phenotype have been studied to try and improve specificity. METHODS AND RESULTS:On bal...

journal_title：Histopathology

authors： Shah KA,Deacon AJ,Dunscombe P,Price AB

更新日期：1997-09-01 00:00:00

abstract：AIMS:Atypical polypoid adenomyoma (APAM) is an uncommon uterine lesion composed of complex endometrioid glands with frequent squamous morular metaplasia and fibromuscular stroma. On endometrial curettage, biopsy, or polypectomy specimens, the admixture of endometrioid glands and smooth muscle raises the differential di...

journal_title：Histopathology

authors： Worrell HI,Sciallis AP,Skala SL

更新日期：2021-01-18 00:00:00

abstract：AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...

journal_title：Histopathology

authors： Jerome Marson V,Mazieres J,Groussard O,Garcia O,Berjaud J,Dahan M,Carles P,Daste G

更新日期：2004-08-01 00:00:00

abstract：AIMS:Maspin, a protein belonging to the serpin superfamily, is the product of a tumour suppressor gene. Tissue distribution studies have shown maspin expression in normal mammary epithelial cells, in the placenta, prostate, thymus, testis, oral cavity, small intestine, skin, and cornea. Maspin is expressed but down-reg...

journal_title：Histopathology

authors： Marioni G,Blandamura S,Giacomelli L,Calgaro N,Segato P,Leo G,Fischetto D,Staffieri A,de Filippis C

更新日期：2005-05-01 00:00:00

abstract：AIMS:The B7 family check-point molecules are potential therapeutic targets in cancer immunotherapy. However, their expression status in human gestational trophoblastic neoplasia (GTN) remains unknown. We investigated the expression profiles of the B7 family check-point proteins PD-L1, PD-L2, B7-H3, B7-H4, VISTA and B7-...

journal_title：Histopathology

authors： Zong L,Zhang M,Wang W,Wan X,Yang J,Xiang Y

更新日期：2019-09-01 00:00:00

abstract：AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...

journal_title：Histopathology

authors： Hatano B,Ohshima K,Katoh A,Kanda M,Kawasaki C,Tsuchiya T,Shimazaki K,Haraoka S,Sugihara M,Suzumiya J,Kikuchi M

更新日期：2002-11-01 00:00:00

abstract：:The syndrome of postmastectomy lymphangiosarcoma (LAS) has been universally accepted since it was first outlined by Stewart & Treves (1948), except for a small number of authors who concluded that the neoplasms arising in the chronic lymphoedematous arms were in fact due to retrograde spread from the original breast c...

journal_title：Histopathology

authors： Schafler K,McKenzie CG,Salm R

更新日期：1979-03-01 00:00:00