Lipoblastoma-like tumour of the vulva: report of three cases of a distinctive mesenchymal neoplasm of adipocytic differentiation.

abstract：AIMS:Follicular lymphoma (FL) in situ is defined as strongly bcl-2-positive B cells in germinal centres of morphologically inconspicuous lymph nodes. The prevalence and biological and clinical significance of this lesion are still not clear. Therefore we aimed at the detection of the prevalence of this phenomenon in an...

journal_title：Histopathology

authors： Henopp T,Quintanilla-Martínez L,Fend F,Adam P

更新日期：2011-07-01 00:00:00

abstract：AIMS:The diagnosis of epithelioid haemangioendothelioma (EHE) is usually straightforward, based on characteristic histological features. However, it is sometimes difficult to differentiate EHE from a variety of other tumours with epithelioid morphology. The WW domain-containing transcription regulator 1-calmodulin-bind...

journal_title：Histopathology

authors： Shibuya R,Matsuyama A,Shiba E,Harada H,Yabuki K,Hisaoka M

更新日期：2015-12-01 00:00:00

abstract：AIMS:Tumour-infiltrating lymphocytes (TILs) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in ductal carcinoma in situ (DCIS) remains uncer...

journal_title：Histopathology

authors： Miligy I,Mohan P,Gaber A,Aleskandarany MA,Nolan CC,Diez-Rodriguez M,Mukherjee A,Chapman C,Ellis IO,Green AR,Rakha EA

更新日期：2017-08-01 00:00:00

abstract：AIMS:MYC is a proto-oncogene that is frequently dysregulated in various malignancies, through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification, and immunohistochemical expression has been shown to be a reliable surrogate marker for amplification, but less is known abo...

journal_title：Histopathology

authors： Mito JK,Qian X,Jo VY,Doyle LA

更新日期：2020-10-01 00:00:00

abstract：AIMS:Immunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic ...

journal_title：Histopathology

authors： Gremel G,Bergman J,Djureinovic D,Edqvist PH,Maindad V,Bharambe BM,Khan WA,Navani S,Elebro J,Jirström K,Hellberg D,Uhlén M,Micke P,Pontén F

更新日期：2014-01-01 00:00:00

abstract：:Problems in the interpretation and diagnosis of intraepithelial lesions of the uterine cervix include interobserver differences in respect of grading, uncertainty as to the significance of human papillomavirus infection and debate about the current terminology. The role of human papillomaviruses in cervical intra-epit...

journal_title：Histopathology

authors： Fox H,Buckley CH

更新日期：1990-07-01 00:00:00

abstract：AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...

journal_title：Histopathology

authors： Hoang LN,Han G,McConechy M,Lau S,Chow C,Gilks CB,Huntsman DG,Köbel M,Lee CH

更新日期：2014-03-01 00:00:00

abstract：AIMS:Pseudosarcomatous myofibroblastic proliferations (PSMPs) of the urinary bladder are diagnostically challenging. Diagnostic difficulties are mainly due to frequent cytokeratin expression, variable ALK expression and worrisome morphological features suggestive of malignancy. Conversely, sarcomatoid urothelial carcin...

journal_title：Histopathology

authors： Bertz S,Stöhr R,Gaisa NT,Wullich B,Hartmann A,Agaimy A

更新日期：2020-12-01 00:00:00

abstract：:A variety of cytomorphological features, architectural patterns and stromal changes may be observed in malignant melanomas. Hence, melanomas may mimic carcinomas, sarcomas, benign stromal tumours, lymphomas, plasmacytomas and germ cell tumours. Melanomas may be composed of large pleomorphic cells, small cells, spindle...

journal_title：Histopathology

authors： Banerjee SS,Harris M

更新日期：2000-05-01 00:00:00

abstract：:A recently described unifying proposal for mantle cell lymphoma has led to the formulation of strict diagnostic criteria based on morphology, immunology and molecular data to define this specific entity. Previous studies were often based on broader definitions such as centrocytic lymphoma, intermediately differentiate...

journal_title：Histopathology

authors： Pittaluga S,Wlodarska I,Stul MS,Thomas J,Verhoef G,Cassiman JJ,Van den Berghe H,de Wolf-Peeters C

更新日期：1995-01-01 00:00:00

abstract：AIMS:Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histol...

journal_title：Histopathology

authors： El Zein S,Boccara O,Soupre V,Vieira AF,Bodemer C,Coulomb A,Wassef M,Fraitag S

更新日期：2020-08-01 00:00:00

abstract：:The published literature is awash with examples of new tissue biomarkers promising to predict responses to therapy in breast cancer patients. However, few, if any, of these progress from the laboratory to the clinic. In this review we discuss some of the reasons for this, illustrating our discussion with a selection o...

journal_title：Histopathology

authors： Faratian D,Bartlett J

更新日期：2008-01-01 00:00:00

abstract：AIMS:We present the histopathological findings of a series of six cases of a benign uterine smooth muscle tumour with an unusual growth pattern. METHODS AND RESULTS:All cases have the appearances of the recently described dissecting (cotyledonoid) leiomyoma. In addition, three of these lesions demonstrate the features...

journal_title：Histopathology

authors： Jordan LB,Al-Nafussi A,Beattie G

更新日期：2002-03-01 00:00:00

abstract：AIMS:Lung cancer patients within the pN0 category have a significantly different outcome. The aim of this study was to develop a mathematical model to assist in predicting the prognosis of pN0 lung squamous cell carcinoma (SCC). METHODS AND RESULTS:Twenty-three proteins were examined by immunohistochemical (IHC) analy...

journal_title：Histopathology

authors： Liu Y,Lin D,Xiao T,Ma Y,Hu Z,Zheng H,Zheng S,Liu Y,Li M,Li L,Cao Y,Guo S,Han N,Di X,Zhang K,Cheng S,Gao Y

更新日期：2011-11-01 00:00:00

abstract：AIMS:Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. METHODS AND...

journal_title：Histopathology

authors： Yamashita K,Kohashi K,Yamada Y,Ishii T,Nishida Y,Urakawa H,Ito I,Takahashi M,Inoue T,Ito M,Ohara Y,Oda Y,Toyokuni S

更新日期：2018-04-01 00:00:00

abstract：AIMS:The available evidence indicates that most non-uterine high-grade serous carcinomas (HGSCs) arise from the fallopian tube (FT), but approaches to primary site assignment have not evolved to reflect this. The aim of this study was to assess the application of recently proposed criteria for site assignment. METHODS...

journal_title：Histopathology

authors： Singh N,Gilks CB,Wilkinson N,McCluggage WG

更新日期：2015-09-01 00:00:00

abstract：AIMS:Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to ass...

journal_title：Histopathology

authors： Stewart M,Turley H,Cook N,Pezzella F,Pillai G,Ogilvie D,Cartlidge S,Paterson D,Copley C,Kendrew J,Barnes C,Harris AL,Gatter KC

更新日期：2003-07-01 00:00:00

abstract：AIMS:Glypican 3 (GPC3) has been reported to be overexpressed in yolk sac tumour (YST), but the sensitivity has not been compared with alpha-fetoprotein (AFP). YST can form numerous growth patterns and the expression of GPC3 in these patterns has not been studied. The aim was to address these aspects. METHODS AND RESUL...

journal_title：Histopathology

authors： Zynger DL,McCallum JC,Luan C,Chou PM,Yang XJ

更新日期：2010-05-01 00:00:00

abstract：:We report a case of oesophageal carcinosarcoma with prominent rhabdomyoblastic differentiation. Immunohistochemically, the rhabdomyblasts were mainly reactive to vimentin, cytokeratin, desmin, muscle-specific actin, myosin, and myoglobin, and were surrounded by laminin and type IV collagen-positive basement membranes....

journal_title：Histopathology

authors： Guarino M,Reale D,Micoli G,Forloni B

更新日期：1993-05-01 00:00:00

abstract：AIMS:Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remark...

journal_title：Histopathology

authors： Bilecz A,Stockhammer P,Theegarten D,Kern I,Jakopovic M,Samarzija M,Klikovits T,Hoda MA,Döme B,Oberndorfer F,Muellauer L,Fillinger J,Kovács I,Pirker C,Schuler M,Plönes T,Aigner C,Klepetko W,Berger W,Brcic L,Laszlo

更新日期：2020-07-01 00:00:00

abstract：:A procedure for the simultaneous fixation and decalcification of bone biopsies is described. Mild acidic fixatives (such as Bouin's fluid) are effective decalcifying agents when made calcium-free by a continuous circulation through a column of anion-binding ion exchange resin. The procedure has been found relatively f...

journal_title：Histopathology

authors： Bussolati G

更新日期：1978-09-01 00:00:00

abstract：:Forty cases of the distinctive but poorly recognized aneurysmal variant of cutaneous fibrous histiocytoma are described. These tumours presented most commonly in middle-age adults, with a slight predilection for females. Anatomical distribution was wide with most cases occurring in the lower limb/limb girdle (50%), up...

journal_title：Histopathology

authors： Calonje E,Fletcher CD

更新日期：1995-04-01 00:00:00

abstract：AIMS:Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci. METHODS AND RESULTS:Seventy-three CRCs with high-grade budding (> 10 budding foci in a x 20 objective field) were cl...

journal_title：Histopathology

authors： Shinto E,Mochizuki H,Ueno H,Matsubara O,Jass JR

更新日期：2005-07-01 00:00:00

abstract：AIMS:Although many immunohistochemical (IHC) cancer biomarkers have been identified, very few have translated into routine clinical practice, primarily because of technical and observational inconsistencies between studies. However, despite the obvious need to address such variability, very few studies have done so. M...

journal_title：Histopathology

authors： Lawrie CH,Ballabio E,Soilleux E,Sington J,Hatton CS,Dirnhofer S,Tzankov A

更新日期：2012-07-01 00:00:00

abstract：AIMS:Pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) are two metabolic and oncogenic markers of cancer. In this study, we sought to investigate their expression patterns and prognostic value in tongue squamous cell carcinoma (TSCC). METHODS AND RESULTS:The expression and subcellular localization of PKM2 a...

journal_title：Histopathology

authors： Yuan C,Li Z,Wang Y,Qi B,Zhang W,Ye J,Wu H,Jiang H,Song LN,Yang J,Cheng J

更新日期：2014-11-01 00:00:00

abstract：:The classification of renal cell neoplasms has been extensively studied in the last decade, and a standardized nomenclature adopted. Although this system is based on a combination of genetic, histological and immunohistological features, in most cases accurate classification can be based on histological features alone...

journal_title：Histopathology

authors： Renshaw AA

更新日期：2002-10-01 00:00:00

abstract：AIMS:Members of the cadherin and catenin families are involved in chondrogenesis and catenin gene mutations have been detected in malignant tumours of bone. This study was undertaken to assess in detail expression of cadherin, beta-catenin and the associated tumour suppressor gene product APC in bone and cartilage at d...

journal_title：Histopathology

authors： Monaghan H,Bubb VJ,Sirimujalin R,Millward-Sadler SJ,Salter DM

更新日期：2001-12-01 00:00:00

abstract：AIM:We describe the unusual association of fallopian tubal prolapse and herpetic infection, an occurrence not previously reported to our knowledge. METHODS AND RESULTS:A 37-year-old woman presented with a small polypoid mass of the vaginal vault, 3 months after abdominal hysterectomy and abdominoplasty. The vaginal ma...

journal_title：Histopathology

authors： Lefrancq T,Orain I,Michalak S,Hourseau M,Fetissof F

更新日期：1999-06-01 00:00:00

abstract：AIMS:  To review the histopathological features of cervical LNs, and to clarify the changes in extracervical LNs, in acute Kawasaki disease (KD). METHODS AND RESULTS:  The samples were obtained from 33 patients with acute-phase KD. We divided the LNs into those in the neck (n = 23) and those located elsewhere (n = 26)...

journal_title：Histopathology

authors： Yokouchi Y,Oharaseki T,Harada M,Ihara F,Naoe S,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：AIMS:Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis. The aim was to investigate the clinical significance of survivin expression in resected hepatocellular carcinoma (HCC) and paired adjacent non-tumour tissue. METHODS AND RESULTS:I...

journal_title：Histopathology

authors： Chau GY,Lee AF,Tsay SH,Ke YR,Kao HL,Wong FH,Tsou AP,Chau YP

更新日期：2007-08-01 00:00:00