Abstract：
:A recently described unifying proposal for mantle cell lymphoma has led to the formulation of strict diagnostic criteria based on morphology, immunology and molecular data to define this specific entity. Previous studies were often based on broader definitions such as centrocytic lymphoma, intermediately differentiated lymphoma or mantle zone lymphoma and, therefore, included a variety of entities with some, but not all, features ascribed to the mantle cell lymphoma. Since the publication of the unifying proposal no comprehensive studies have been published to confirm and support it. We selected 55 cases of mantle cell lymphoma collected in our institution in order to evaluate the validity of the proposal and, by using strict criteria, we analysed the morphological features, their variations and the changes occurring in the course of the disease as well as its clinical behaviour. The analysis of this material demonstrates that mantle cell lymphoma affects predominantly elderly males presenting with an advanced stage of disease. Twenty-four out of 55 patients died with, or of, the disease with a median survival of 32 months, even though most of them received aggressive chemotherapy. In all cases the histological features were strikingly uniform and most cases had a diffuse growth pattern. The neoplastic cells corresponded to small cleaved cells with a minimal variation in shape and size from one case to the other. The phenotype of the neoplastic cells was remarkably constant with expression of several pan-B cell markers, IgM, IgD and CD5, and lack of CD10 and CD23.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Histopathologyjournal_title
Histopathologyauthors
Pittaluga S,Wlodarska I,Stul MS,Thomas J,Verhoef G,Cassiman JJ,Van den Berghe H,de Wolf-Peeters Cdoi
10.1111/j.1365-2559.1995.tb00615.xsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
17-24issue
1eissn
0309-0167issn
1365-2559journal_volume
26pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract：:The clinical, light microscopic and immunohistochemical features of six cutaneous heterotopic meningeal nodules (primary, or type I, cutaneous meningiomas) are described. These are rare lesions of the scalp and back which generally present at birth or in childhood. They appear as small subcutaneous fibrous nodules, wi...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1990.tb01547.x
更新日期：1990-05-01 00:00:00
abstract：AIMS:An increased risk of adenocarcinoma of the oesophagus has been demonstrated in patients with long segments of Barrett's mucosa. The risk of cancer associated with short segments of metaplasia of the oesophagogastric junction is not known. METHODS AND RESULTS:We report a case of early adenocarcinoma of the oesopha...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.1997.5910816.x
更新日期：1997-07-01 00:00:00
abstract：AIMS:Diversion colitis (DC) is a localized, relatively benign, iatrogenic condition which occurs in almost 100% of diverted colonic segments in patients who undergo ileostomy/colostomy for various reasons. The aim of this study was to establish histological features of DC in children. METHODS AND RESULTS:Twenty-three ...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.2000.00803.x
更新日期：2000-01-01 00:00:00
abstract：AIMS:Angiogenesis is essential for tumour growth and metastasis and tumour necrosis factor (TNF)-alpha is a potent angiogenic factor. Invasive micropapillary carcinoma of the breast (IMPC), a rare subtype of breast cancer, possesses a lymphotropic nature with a high incidence of lymph node metastasis and poor prognosis...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2008.03128.x
更新日期：2008-10-01 00:00:00
abstract：:Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes simila...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1990.tb00660.x
更新日期：1990-07-01 00:00:00
abstract：AIMS: Three histological variants of dysembryoplastic neuroepithelial tumour (DNT) have been described, namely, simple, complex and non-specific. However, the concept of non-specific variants of DNT remains controversial, because they cannot be accurately distinguished by histological findings alone from ordinary gliom...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2011.03936.x
更新日期：2011-08-01 00:00:00
abstract：AIMS:Rare gastric lesions composed of a combined proliferation of chief and oxyntic cells have been variably called adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. Herein, we present a series of cases that show a morphological spectrum of chief and oxyntic cell proliferations. METHODS AND RESULTS:...
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1111/his.12859
更新日期：2016-05-01 00:00:00
abstract：AIMS:Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia-associated transcription factor family on chromosome Xp11.2. Dual-colour break-apart fluorescence in-situ hybridisation (FISH) is recommended to confir...
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1111/his.13866
更新日期：2019-08-01 00:00:00
abstract：AIMS:Carbonic anhydrase VI (CA6) is present in serous acinar cells of human salivary glands. The aim of this study was to investigate the diagnostic utility of CA6 in differentiating acinic cell carcinoma (AciCC) from its morphological mimic mammary analogue secretory carcinoma (MASC) of the salivary gland. METHODS AN...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.12792
更新日期：2016-04-01 00:00:00
abstract：:Three cases of gastric parietal cell carcinoma are described. Tumour cells are round to polygonal, with abundant eosinophilic, granular cytoplasm reactive with phosphotungstic acid haematoxylin and Luxol Fast Blue. Ultrastructurally the tumour cells are characterized by abundant mitochondria, tubulovesicles, intracell...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1984.tb02397.x
更新日期：1984-09-01 00:00:00
abstract：:A total of 118 biopsies from 20 different types of benign, malignant and reactive vascular proliferations were examined for the expression of the CD30 antigen using the monoclonal antibodies BerH2 and HRS4 on paraffin-embedded sections. The results were compared with those obtained using an antibody directed against t...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1993.tb00476.x
更新日期：1993-08-01 00:00:00
abstract：AIMS:We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS:Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.1999.00582.x
更新日期：1999-01-01 00:00:00
abstract：AIMS:To investigate whether localization of beta-catenin is helpful in differentiating primary ovarian mucinous carcinoma and colorectal adenocarcinoma metastatic to the ovary. Extra-ovarian cancers which metastasize to the ovaries, especially from colorectal adenocarcinoma, frequently mimic primary ovarian carcinomas,...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.2003.01687.x
更新日期：2003-08-01 00:00:00
abstract：AIMS:To document the clinical, light microscopic, immunohistochemical and ultrastructural features of four cases of extra-orbital giant cell angiofibromas. METHODS AND RESULTS:Sections of formalin-fixed paraffin-embedded specimens were studied by haematoxylin and eosin, reticulin and immunohistochemical stains. Electr...
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2559.2001.01227.x
更新日期：2001-10-01 00:00:00
abstract：AIMS:To study the current work practice of histopathologists to inform the design of digital microscopy systems. METHODS AND RESULTS:Four gastrointestinal histopathologists were video-recorded as they undertook their routine work. Analysis of the video data shows a range of activities beyond viewing slides involved in...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2011.04090.x
更新日期：2012-02-01 00:00:00
abstract：AIMS:Rosette-forming malignant lymphoma is very rare. We report a blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase (TdT) with formation of Homer-Wright type pseudorosettes. METHODS AND RESULTS:An 18-year-old boy presented with an enlarged inguinal lymph node. Histologically, the nodal architec...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.1998.00571.x
更新日期：1998-12-01 00:00:00
abstract：AIMS:To analyse the expression of alphavbeta6, an epithelial integrin involved in wound healing and tumorigenesis, in various human carcinoma types. METHODS AND RESULTS:A new monoclonal antibody to the human beta6 subunit, 5C4, was used to locate alphavbeta6 in 157 cancers of gastroenteropancreatic and 21 of lung orig...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2004.01919.x
更新日期：2004-09-01 00:00:00
abstract：AIMS:Intestinal metaplasia (IM) has been implicated in the pathogenesis of gastro-oesophageal carcinoma, but because of its common occurrence, its specificity for use in cancer surveillance is low. IM subtypes characterized by mucin phenotype have been studied to try and improve specificity. METHODS AND RESULTS:On bal...
journal_title：Histopathology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2559.1997.2110847.x
更新日期：1997-09-01 00:00:00
abstract：AIMS:The B7 family check-point molecules are potential therapeutic targets in cancer immunotherapy. However, their expression status in human gestational trophoblastic neoplasia (GTN) remains unknown. We investigated the expression profiles of the B7 family check-point proteins PD-L1, PD-L2, B7-H3, B7-H4, VISTA and B7-...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.13882
更新日期：2019-09-01 00:00:00
abstract：:We present a 27-year-old woman with non-systemic diffuse lymphangiomatosis of spleen and liver. The tumour consisted of capillary and cavernous lymphatic vessels located in abundant fibrous tissue. The vascular endothelium showed immunoreactivity for factor VIII-related antigen. A basal lamina could be demonstrated im...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1991.tb00884.x
更新日期：1991-05-01 00:00:00
abstract：AIMS:There have been several cell kinetic studies of thymoma, but the effectiveness of using Ki67 antibody as a tool to measure proliferative activity in this tumour was rarely evaluated. We carried out an immuno-histochemical study using this antibody to assess the clinicopathological correlation and the prognostic si...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1046/j.1365-2559.1998.00504.x
更新日期：1998-11-01 00:00:00
abstract：:One hundred and eighty-seven operable lung tumours were immunostained with the monoclonal antibody Ki-67 and divided into groups of high, moderate or low proliferation. Patients have been followed clinically for up to 7 years to ascertain whether this immunocytochemical measurement reflected tumour behaviour in terms ...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1991.tb01503.x
更新日期：1991-12-01 00:00:00
abstract：:A series of 115 consecutive, non-ulcerous, dyspeptic patients were examined for Helicobacter pylori (H. pylori) colonization in the gastric antral and/or body mucosa using Giemsa staining. Findings were correlated with the presence and degree of activity of superficial gastritis, deep gastritis, atrophic gastritis and...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1993.tb00062.x
更新日期：1993-01-01 00:00:00
abstract：AIMS:MUC4 is a transmembrane glycoprotein that plays a role in cell growth signalling and is expressed in various epithelial tissues. Gene expression profiling and immunohistochemical analyses revealed that MUC4 is also constantly and specifically expressed in low-grade fibromyxoid sarcomas and sclerosing epithelioid f...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.13730
更新日期：2019-01-01 00:00:00
abstract：AIMS:In oesophageal adenocarcinoma, detection rates of venous invasion using haematoxylin and eosin (H&E) and elastic stains have not been compared. The aims of this study were to investigate whether or not elastic stains facilitate the detection of venous invasion, and to determine the prognostic significance of venou...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.12308
更新日期：2014-04-01 00:00:00
abstract：AIMS:To validate the use of the silver-enhanced in situ hybridization (SISH) technique in assessing HER2 status of breast carcinoma in excision biopsy specimens, and to assess its reliability in determining HER2 status in core biopsy specimens. METHODS AND RESULTS:Routinely processed paraffin sections of 65 excised br...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.2008.03185.x
更新日期：2009-01-01 00:00:00
abstract：AIMS:Telomerase is reactivated in most cancers and there is accumulating evidence that this is a driver event in malignant melanoma (MM). Thus, our aim was to evaluate if in-situ hybridization (ISH)-based quantification of telomerase RNA (hTR) could be used to distinguish MM from naevi, and if there was a correlation w...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/his.12501
更新日期：2015-04-01 00:00:00
abstract：AIMS:Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic. RESULTS:The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immuno...
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1111/his.12733
更新日期：2015-12-01 00:00:00
abstract：:Apoptotic bodies were investigated ultrastructurally in 10 cases of squamous cell carcinoma taken from buccal mucosa, tongue and larynx. Epithelial cells undergoing mitosis were found to show premature formation of nuclear membranes around various aggregates of chromosomal material giving the appearance of micronuclei...
journal_title：Histopathology
pub_type： 杂志文章
doi：10.1111/j.1365-2559.1986.tb02590.x
更新日期：1986-09-01 00:00:00
abstract：:Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical...
journal_title：Histopathology
pub_type： 杂志文章,评审
doi：10.1111/his.13380
更新日期：2018-01-01 00:00:00
